Results 1 to 10 of about 125 (122)
Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs [PDF]
Molecules, 2020 Scaffold hopping is a frequently-used strategy in the development of non-nucleoside reverse transcriptase inhibitors. Herein, CH(CN)-DAPYs were designed by hopping the cyano-methylene linker of our previous published CH(CN)-DABOs onto the etravirine (ETR)
Ting-Ting Li +4 more
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Journal of Medicinal Chemistry, 2021 A series of novel heteroaromatic-difluoro-biphenyl-diarylpyrimidines were designed as non-nucleoside anti-HIV inhibitors targeting reverse transcriptase by a fragment-based replacement strategy with the purpose of improving the druggability. Hopping five- or six-membered heterocycle groups on the biphenyl moiety as bioisosterism for intrinsically ...
Li Ding +4 more
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Hydrogen Bonding (Base Pairing) in Antiviral Activity
Viruses, 2023 Base pairing based on hydrogen bonding has, since its inception, been crucial in the antiviral activity of arabinosyladenine, 2′-deoxyuridines (i.e., IDU, TFT, BVDU), acyclic nucleoside analogues (i.e., acyclovir) and nucleoside reverse transcriptase ...
Erik De Clercq
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Pharmaceuticals, 2022 HIV-1 reverse transcriptase (RT) plays a crucial role in the viral replication cycle, and RT inhibitors can represent a promising pathway in treating AIDS.
Tao Zhang +8 more
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Distributed Optimal Secondary Frequency Control in Power Networks with Delay Independent Stability [PDF]
IEEE Transactions on Automatic Control,2023, 2022 Distributed secondary frequency control for power systems, is a problem that has been extensively studied in the literature, and one of its key features is that an additional communication network is required to achieve optimal power allocation.
arxiv +1 more source
Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV
Pharmaceuticals, 2020 In the treatment of acquired immune deficiency syndrome (AIDS), the diarylpyrimidine (DAPY) analogs etravirine (ETR) and rilpivirine (RPV) have been widely effective against human immunodeficiency virus (HIV) variants that are resistant to other non ...
Daniel M. Himmel, Eddy Arnold
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Cell segmentation of in situ transcriptomics data using signed graph partitioning [PDF]
GbRPR 2023. Lecture Notes in Computer Science, vol 14121.
Springer, Cham, 2023 The locations of different mRNA molecules can be revealed by multiplexed in situ RNA detection. By assigning detected mRNA molecules to individual cells, it is possible to identify many different cell types in parallel. This in turn enables investigation of the spatial cellular architecture in tissue, which is crucial for furthering our understanding ...
arxiv +1 more source
Molecular Models of DAPI [PDF]
Journal of Chemical Education, 2007 This month’s Featured Molecule is DAPI (4',6-diamidino-2-phenylindole), a minor-groove binder to DNA.
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Shared lateral control with on-line adaptation of the automation degree for driver steering assist system: A weighting design approach [PDF]
2015 54th IEEE Conference on Decision and Control (CDC), Dec 2015,
Osaka, France. pp.857-862, 2020 This paper addresses the shared lateral control for both lane-keeping and obstacle avoidance tasks of a driver steering assist system (DSAS). In this work, we propose a novel approach to deal with the interactions between the human (driver) and the machine (DSAS) by introducing into the vehicle system a fictive nonlinear term representing the driver ...
arxiv +1 more source
Labeling Nuclear DNA Using DAPI [PDF]
Cold Spring Harbor Protocols, 2011 INTRODUCTIONA number of fluorescent stains are available that label DNA and allow easy visualization of the nucleus in interphase cells and chromosomes in mitotic cells, including Hoechst, 4′,6-diamidino-2-phenylindole (DAPI), ethidium bromide, propidium iodide, and acridine orange.
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