Results 11 to 20 of about 112 (105)

Research Progress in HIV and Mycobacterium tuberculosis Inhibitors Containing Sulfonamide Moiety

open access: yesJournal of Chemistry, Volume 2023, Issue 1, 2023., 2023
Numerous studies have reported significant results regarding the efficacy of sulfonamides against Mycobacterium tuberculosis and various HIV strains. This scientific paper provides an overview of the progress made over a decade of sulfonamides against HIV‐1 and mycobacteria and its development against extremely drug‐resistant (XDR) and multidrug ...
Christiana Abimbola Salubi   +1 more
wiley   +1 more source

HIV‐1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial

open access: yesJournal of the International AIDS Society, Volume 24, Issue 11, November 2021., 2021
Abstract Introduction A potential concern with the use of dapivirine (DPV) for HIV prevention is the selection of a drug‐resistant virus that could spread and reduce the effectiveness of non‐nucleoside reverse transcriptase (NNRTI)‐based first‐line antiretroviral therapy.
Urvi M. Parikh   +15 more
wiley   +1 more source

The Need for Development of New HIV‐1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance

open access: yesScientifica, Volume 2012, Issue 1, 2012., 2012
The use of highly active antiretroviral therapy (HAART) involves combinations of drugs to achieve maximal virological response and reduce the potential for the emergence of antiviral resistance. There are two broad classes of reverse transcriptase inhibitors, the nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse ...
Mark A. Wainberg   +4 more
wiley   +1 more source

Powering the Future: Opportunities and Obstacles in Lead‐Halide Inorganic Perovskite Solar Cells

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
This review explores recent advancements, challenges, and future opportunities in the low‐cost fabrication of efficient inorganic perovskite solar cells (PSCs). It focuses on the manufacturing of PSCs under ambient conditions using low‐temperature processes.
Narendra Pai, Dechan Angmo
wiley   +1 more source

Torsional Dynamics and Orientation of DNA−DAPI Complexes [PDF]

open access: yesBiochemistry, 1996
The flexibility of calf thymus DNA and several polynucleotides was measured using the anisotropy decay of DAPI bound to DNA, a minor groove probe. DNA torsional dynamics were analyzed using the Schurr model [Allison, S. A., & Schurr, J. M. (1979) Chem. Phys. 41, 35-44] in the infinite polymer length approximation.
Barcellona, Maria Luisa, Gratton, Enrico
openaire   +4 more sources

Covalent Organic Frameworks and 2D Materials Hybrids: Synthesis Strategies, Properties Enhancements, and Future Directions

open access: yesSmall, Volume 21, Issue 8, February 25, 2025.
This review presents the current state of 2D materials (2DMs) ‐ covalent organic frameworks (COFs) hybrids, focusing on their physicochemical properties, synthesis methods, and applications in sensing, catalysis, energy storage, and filtration. It outlines the strengths and weaknesses of 2DMs and COFs, highlights synergistic benefits from hybridization,
Cataldo Valentini   +4 more
wiley   +1 more source

Monkeypox: Origin, Transmission, Clinical Manifestations, Prevention, and Therapeutic Options

open access: yesInterdisciplinary Perspectives on Infectious Diseases, Volume 2025, Issue 1, 2025.
Monkeypox is a rapidly spreading transmissible disease induced by the monkeypox virus (MPXV), a major public health problem worldwide. The origin of monkeypox might be tracked to the continent of Africa, where it first afflicted primate species prior to spreading to the world.
Sajal Kumar Halder   +4 more
wiley   +1 more source

Synthesis of 4‐(Phenylamino)quinazoline‐2(1H)‐thiones Using Green Solvents

open access: yesChemistry – A European Journal, Volume 30, Issue 63, November 12, 2024.
Environmentally friendly process for synthesizing heterocyclic molecules of therapeutic interest with the quinazoline‐2(1H)‐thione core structure, using bio‐based recyclable solvents. Abstract Given the importance of quinazolines and quinazolinethiones in therapeutic and Food and Drug Administration (FDA)‐approved molecules, we thought interesting to ...
Gatien Messire   +2 more
wiley   +1 more source

Pharmacological advances in anti‐retroviral therapy for human immunodeficiency virus‐1 infection: A comprehensive review

open access: yesReviews in Medical Virology, Volume 34, Issue 2, March 2024.
Abstract The discovery of anti‐retroviral (ARV) drugs over the past 36 years has introduced various classes, including nucleoside/nucleotide reverse transcriptase inhibitors, non‐nucleoside reverse transcriptase inhibitors, protease inhibitor, fusion, and integrase strand transfer inhibitors inhibitors.
Nursyuhada Azzman   +6 more
wiley   +1 more source

The tautomer‐specific excited state dynamics of 2,6‐diaminopurine using resonance‐enhanced multiphoton ionization and quantum chemical calculations

open access: yesPhotochemistry and Photobiology, Volume 100, Issue 2, Page 404-418, March/April 2024.
1,6‐Diaminopurine excited state dynamics depends critically on tautomeric form. Abstract 2,6‐Diaminopurine (2,6‐dAP) is an alternative nucleobase that potentially played a role in prebiotic chemistry. We studied its excited state dynamics in the gas phase by REMPI, IR‐UV hole burning, and ps pump‐probe spectroscopy and performed quantum chemical ...
Gregory Gate   +5 more
wiley   +1 more source

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