Results 21 to 30 of about 198 (126)

Research Progress in HIV and Mycobacterium tuberculosis Inhibitors Containing Sulfonamide Moiety

Journal of Chemistry, Volume 2023, Issue 1, 2023., 2023
Numerous studies have reported significant results regarding the efficacy of sulfonamides against Mycobacterium tuberculosis and various HIV strains. This scientific paper provides an overview of the progress made over a decade of sulfonamides against HIV‐1 and mycobacteria and its development against extremely drug‐resistant (XDR) and multidrug ...
Christiana Abimbola Salubi, Vijay Kumar Siripuram   +1 more
wiley   +1 more source

HIV‐1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial

Journal of the International AIDS Society, Volume 24, Issue 11, November 2021., 2021
Abstract Introduction A potential concern with the use of dapivirine (DPV) for HIV prevention is the selection of a drug‐resistant virus that could spread and reduce the effectiveness of non‐nucleoside reverse transcriptase (NNRTI)‐based first‐line antiretroviral therapy.
Urvi M. Parikh, Kerri J. Penrose, Amy L. Heaps, Elias K. Halvas, B. Jay Goetz, Kelley C. Gordon, Russell Hardesty, Rahil Sethi, William Schwarzmann, Daniel W. Szydlo, Marla J. Husnik, Uma Chandran, Thesla Palanee‐Phillips, Jared M. Baeten, John W. Mellors, the MTN‐020 Study Team   +15 more
wiley   +1 more source

Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. [PDF]

J Med Chem, 2012
Twenty-one new 4-substituted diarylaniline compounds (DAANs) (Scheme 2, series 13, 14, and 15) were designed, synthesized, and evaluated against wild-type and drug resistant HIV-1 viral strains.
Sun LQ, Zhu L, Qian K, Qin B, Huang L, Chen CH, Lee KH, Xie L.   +7 more
europepmc   +3 more sources

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors

, 2019
The fragment hopping approach is widely applied in drug development. A series of diarylpyrimidines (DAPYs) were obtained by hopping the thioacetamide scaffold to novel human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase ...
Sheng Han, Ya-Li Sang, Yan Wu, Yuan Tao, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen   +7 more
openalex   +2 more sources

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization

, 2017
A novel series of uracil-bearing DAPYs derivatives were designed and synthesized via structure-based molecular hybridization to discover compounds with improved anti-resistance profiles. Anti-HIV activity of the designed compounds was tested in MT-4 cell
Heng Zhang, Ye Tian, Dongwei Kang, Zhipeng Huo, Zhongxia Zhou, Huiqing Liu, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu   +9 more
openalex   +3 more sources

Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS. [PDF]

ChemMedChem, 2014
Nineteen new halogenated diarylpyridinamine (DAPA) analogues (6a-n and 8a-e) modified on the phenoxy C-ring were synthesized and evaluated for anti-HIV activity and certain drug-like properties. Ten compounds showed high anti-HIV activity (EC50 0.3, LLE
Wu ZY, Liu N, Qin B, Huang L, Yu F, Qian K, Morris-Natschke SL, Jiang S, Chen CH, Lee KH, Xie L.   +10 more
europepmc   +3 more sources

Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors. [PDF]

J Med Chem, 2010
By using structure-based drug design and isosteric replacement, diarylaniline and 1,5-diarylbenzene-1,2-diamine derivatives were synthesized and evaluated against wild type HIV-1 and drug-resistant viral strains, resulting in the discovery of ...
Qin B, Jiang X, Lu H, Tian X, Barbault F, Huang L, Qian K, Chen CH, Huang R, Jiang S, Lee KH, Xie L.   +11 more
europepmc   +3 more sources

การศึกษาอันตรกิริยาของอนุพันธ์ควิโนลีนกับเอนไซม์ HIV-1 RT โดยใช้เทคนิคทางเคมีควอนตัม [PDF]

, 2021
MASTER OF SCIENCE (M.Sc.)วิทยาศาสตรมหาบัณฑิต (วท.ม.)HIV-1 (Human Immunodeficiency Virus Type 1) is a major cause of AIDS and there are currently several inhibitors used to treat AIDS patients.

core  

Synthesis, anti-HIV activity and molecular modeling study of some new pyrimidine analogues [PDF]

, 2014
A new series of 2,6-diamino-5-arylazo-4-chloropyrimidine analogues (6-13) were synthesized from the pyrimidine scaffold 5, via diazotization with various amines. Nucleophilic displacement of compound 5 by ethanethiolate or arylthio nucleophiles, afforded
Al-Masoudi, Al-Masoudi, Davis, Davis, Dudhea, Jain, Kimura, Monge, Patel, Xu   +9 more
core   +1 more source

Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors [PDF]

, 2006
In spite of the tremendous advance in our understanding of the HIV-1 life cycle and of the molecular mechanisms underlying its pathogenesis, it is still not possible to fully control the HIV-1 infection for long periods of time, not to mention eradicate ...
Giovanni Maga, SILVESTRI, Romano
core   +1 more source