Results 41 to 50 of about 198 (126)

Synthesis of 4‐(Phenylamino)quinazoline‐2(1H)‐thiones Using Green Solvents

open access: yesChemistry – A European Journal, Volume 30, Issue 63, November 12, 2024.
Environmentally friendly process for synthesizing heterocyclic molecules of therapeutic interest with the quinazoline‐2(1H)‐thione core structure, using bio‐based recyclable solvents. Abstract Given the importance of quinazolines and quinazolinethiones in therapeutic and Food and Drug Administration (FDA)‐approved molecules, we thought interesting to ...
Gatien Messire   +2 more
wiley   +1 more source

Pharmacological advances in anti‐retroviral therapy for human immunodeficiency virus‐1 infection: A comprehensive review

open access: yesReviews in Medical Virology, Volume 34, Issue 2, March 2024.
Abstract The discovery of anti‐retroviral (ARV) drugs over the past 36 years has introduced various classes, including nucleoside/nucleotide reverse transcriptase inhibitors, non‐nucleoside reverse transcriptase inhibitors, protease inhibitor, fusion, and integrase strand transfer inhibitors inhibitors.
Nursyuhada Azzman   +6 more
wiley   +1 more source

A survey of isatin hybrids and their biological properties [PDF]

open access: yes
The emergence of diverse infections worldwide, which is a serious global threat to human existence, necessitates the urgent development of novel therapeutic candidates that can combat these diseases with efficacy.
Eni, Donatus Bekindaka   +2 more
core   +1 more source

The tautomer‐specific excited state dynamics of 2,6‐diaminopurine using resonance‐enhanced multiphoton ionization and quantum chemical calculations

open access: yesPhotochemistry and Photobiology, Volume 100, Issue 2, Page 404-418, March/April 2024.
1,6‐Diaminopurine excited state dynamics depends critically on tautomeric form. Abstract 2,6‐Diaminopurine (2,6‐dAP) is an alternative nucleobase that potentially played a role in prebiotic chemistry. We studied its excited state dynamics in the gas phase by REMPI, IR‐UV hole burning, and ps pump‐probe spectroscopy and performed quantum chemical ...
Gregory Gate   +5 more
wiley   +1 more source

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV‑1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

open access: yes, 2019
Diarylpyrimidine derivatives (DAPYs) exhibit robust anti-HIV-1 potency, although they have been compromised by E138K variant and severe side-effects and been suffering from poor water solubility.
Boshi Huang (3080169)   +16 more
core   +4 more sources

Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs

open access: yes, 2011
A series of 18 cycloalkyl arylpyrimidines (CAPYs) were designed from lead compounds diarylpyrimidines (DAPYs), synthesized and evaluated for in vitro anti-HIV activity.
Christophe Pannecouque   +8 more
core   +1 more source

Estudio de nuevos inhibidores de la transcriptasa inversa no nucleosídicos con adictividad antiviral contra el virus de la inmunodeficiencia humana 1 en combinación con acetato de zinc, para su potencial uso como microbicidas de amplio espectro [PDF]

open access: yes, 2013
Tesis - Doctorado en Ciencias de la Salud - Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaria de Graduados en Ciencias de la Salud, 2013 118 h. : il., 29 cm.Fil: Fernández Romero, José Abel. Population Council: Ideas, Evidence,
Fernández Romero, José Abel
core  

Photoperiodism in Digitaria exilis (Kipp) Stapf accessions

open access: yes, 2005
Three varieties of Digitaria exilis namely, white mbulus, jakashale and red dapys were grown in planting chamber and the effect of photoperiod on flowering was investigated. The photoperiods were eleven, twelve and thirteen hours.
Aliero, A A, Morakinyo, J A
core   +1 more source

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