Results 51 to 60 of about 8,310 (209)

Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2008
AbstractSmooth pursuit eye movement (SPEM) deficit is an established schizophrenia endophenotype with a similar neurocognitive construct to working memory. Frontal eye field (FEF) neurons controlling SPEM maintain firing when visual sensory information is removed, and their firing rates directly correlate with SPEM velocity.
Ikwunga, Wonodi, L Elliot, Hong, O Colin, Stine, Braxton D, Mitchell, Amie, Elliott, Rosalinda C, Roberts, Robert R, Conley, Robert P, McMahon, Gunvant K, Thaker   +8 more
openaire   +2 more sources

Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses

European Psychiatry, 2022
Introduction Better evaluation and understanding of the core symptoms have key importance both in clinical practice and the research of attention-deficit hyperactivity disorder (ADHD).
L. Balogh, A. Pulay, N. Angyal, K. Vincze, T. Kilencz, Z. Nemoda, J. Réthelyi   +6 more
doaj   +1 more source

DRD4 and DAT1 VNTR Genotyping in Children with Attention Deficit Hyperactivity Disorder [PDF]

Indian Journal of Clinical Biochemistry, 2016
The dopamine receptor-D4 and the dopamine transporter have been investigated for their role in attention deficit hyperactivity disorder (ADHD) in children. Reports of their genetic association with ADHD have shown mixed results. The aim of the study was to evaluate the association of variable number tandem repeats (VNTRs) of the DRD4 and DAT1 genes ...
Ashley, Stanley, K, Chavda, A, Subramanian, S V, Prabhu, T F, Ashavaid   +4 more
openaire   +2 more sources

The presence of both serotonin 1A receptor (HTR1A) and dopamine transporter (DAT1) gene variants increase the risk of borderline personality disorder

Frontiers in Genetics, 2014
Dysfunction in the dopaminergic and serotonergic neurotransmitter systems has been demonstrated to be important in the aetiology of Borderline personality disorder (BPD).
Peter R Joyce, John eStephenson, Martin A Kennedy, Roger T Mulder, Patrick C Mchugh   +4 more
doaj   +1 more source

Dopamine Related Genes Differentially Affect Declarative Long-Term Memory in Healthy Humans

Frontiers in Behavioral Neuroscience, 2020
In humans, monetary reward can promote behavioral performance including response times, accuracy, and subsequent recognition memory. Recent studies have shown that the dopaminergic system plays an essential role here, but the link to interindividual ...
Carla Leukel, Dirk Schümann, Raffael Kalisch, Raffael Kalisch, Raffael Kalisch, Tobias Sommer, Nico Bunzeck, Nico Bunzeck, Nico Bunzeck   +8 more
doaj   +1 more source

DAT1 and BDNF polymorphisms interact to predict Aβ and tau pathology. [PDF]

Neurobiol Aging
Previous work has associated polymorphisms in the dopamine transporter gene (rs6347 in DAT1/SLC6A3) and brain derived neurotrophic factor gene (Val66Met in BDNF) with atrophy and memory decline. However, it is unclear whether these polymorphisms relate to atrophy and cognition through associations with Alzheimer's disease pathology.
Ciampa CJ, Morin TM, Murphy A, Joie R, Landau SM, Berry AS, Alzheimer’s Disease Neuroimaging Initiative.   +6 more
europepmc   +3 more sources

The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task [PDF]

, 2016
Dopaminergic brain circuits participate in emotional processing and impulsivity. The dopamine transporter (DAT) modulates dopamine reuptake. A variable number tandem repeat (VNTR) in the dopamine transporter gene (DAT1) affects DAT expression.
Anand, Amit, Brown, Brenna K., Karne, Harish, Murrell, Jill   +3 more
core   +1 more source

The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors. [PDF]

PLoS ONE, 2010
This study tests the specific hypothesis that the 9R/9R genotype in the VNTR of the dopamine transporter gene (DAT1) exerts a general protective effect against a spectrum of risky behaviors in comparison to the 10R/9R and 10R/10R genotypes, drawing on ...
Guang Guo, Tianji Cai, Rui Guo, Hongyu Wang, Kathleen Mullan Harris   +4 more
doaj   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome

Frontiers in Behavioral Neuroscience, 2016
Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to ...
Laura Del Hoyo, Laura Del Hoyo, Laura Xicota, Laura Xicota, Laura Xicota, Klaus Langohr, Klaus Langohr, Gonzalo Sánchez-Benavides, Susana De Sola, Susana De Sola, Aida M Cuenca-Royo, Joan Rodriguez, Josep Rodriguez, Magi Farre, Mara Dierssen, Mara Dierssen, Mara Dierssen, Rafael De La Torre, Rafael De La Torre, Rafael De La Torre   +19 more
doaj   +1 more source