Results 121 to 130 of about 13,470,212 (338)

Teaching spatial data science

Geoforum Perspektiv
Spatial data science is an emerging field building on geographic information science, geography, and data science. Here we first discuss the definition and history of the field, arguing that it indeed warrants a new label. Then, we present the design of
Ane Rahbek Vierø, Michael Szell
doaj   +1 more source

Broadening Access to Space Science Data: The Astromaterials Data System [PDF]

, 2020
Jennifer Mays, Lucia Profeta, Kerstin Lehnert, Peng Ji, Shaunna M. Morrison, Annika Johansson, Lulin Song, Juan David Figueroa, Cindy Evans, R. A. Zeigler   +9 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Kaleidoscopic Data Science

Harvard Data Science Review, 2022
David C. Parkes
doaj   +1 more source

Weak lensing magnification in the Dark Energy Survey Science Verification data [PDF]

, 2018
M. Garcia-Fernandez, E. Sánchez, I. Sevilla-Noarbe, E. Suchyta, Eric Huff, E. Gaztañaga, J. Aleksić, Rafael Ponce, F. J. Castander, B. Hoyle, T. M. C. Abbott, F. B. Abdalla, S. Allam, J. Annis, A. Benoit-Lévy, G. M. Bernstein, E. Bertin, D. Brooks, E. Buckley‐Geer, D. L. Burke, A. Carnero Rosell, M. Carrasco Kind, J. Carretero, M. Crocce, C. E. Cunha, C. B. D’Andrea, L. N. da Costa, D. L. DePoy, S. Desai, H. T. Diehl, T. F. Eifler, A. E. Evrard, E. Fernández, B. Flaugher, P. Fosalba, J. Frieman, J. García-Bellido, D. W. Gerdes, T. Giannantonio, D. Gruen, R. A. Gruendl, J. Gschwend, G. Gutiérrez, D. J. James, Mike Jarvis, D. Kirk, E. Krause, K. Kuehn, N. Kuropatkin, O. Lahav, M. Lima, N. MacCrann, M. A. G. Maia, M. March, J. L. Marshall, P. Melchior, R. Miquel, J. J. Mohr, A. A. Plazas, A. K. Romer, A. Roodman, E. S. Rykoff, V. Scarpine, M. Schubnell, R. C. Smith, M. Soares-Santos, F. Sobreira, G. Tarlé, D. Thomas, A. R. Walker, W. C. Wester, NULL AUTHOR_ID   +71 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Automating biomedical data science through tree-based pipeline optimization

, 2016
Over the past decade, data science and machine learning has grown from a mysterious art form to a staple tool across a variety of fields in academia, business, and government.
Andrews, Peter C., Kidd, La Creis, Lavender, Nicole A., Moore, Jason H., Olson, Randal S., Urbanowicz, Ryan J.   +5 more
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source