Results 41 to 50 of about 453,721 (346)

Nucleic acid crystallography: A view from the nucleic acid database

Progress in Biophysics and Molecular Biology, 1996
What are the future directions of the field of nucleic acid crystallography? Although there have been many duplex structures determined, the sample is still relatively small. This is especially true if one wants to derive enough information about the relationships between sequence and structure.
H M, Berman, A, Gelbin, J, Westbrook
openaire   +2 more sources

MODBASE, a database of annotated comparative protein structure models and associated resources. [PDF]

, 2008
MODBASE (http://salilab.org/modbase) is a database of annotated comparative protein structure models. The models are calculated by MODPIPE, an automated modeling pipeline that relies primarily on MODELLER for fold assignment, sequence-structure alignment,
Barkan, David T, Carter, Hannah, Davis, Fred P, Eramian, David, Eswar, Narayanan, Karchin, Rachel, Kelly, Libusha, Mankoo, Parminder, Marti-Renom, Marc A, Pieper, Ursula, Sali, Andrej, Webb, Ben M   +11 more
core   +2 more sources

A Systematic Review and Meta-analysis of the Diagnostic Accuracy of Nucleic Acid Amplification Tests for Tuberculous Meningitis

Journal of Clinical Microbiology, 2019
The diagnosis of tuberculous meningitis (TBM) is difficult and poses a significant challenge to physicians worldwide. Recently, nucleic acid amplification (NAA) tests have shown promise for the diagnosis of TBM, although their performance has been ...
A. Pormohammad, M. Nasiri, Timothy D McHugh, S. Riahi, N. Bahr   +4 more
semanticscholar   +1 more source

Inferring the presence of aflatoxin-producing Aspergillus flavus strains using RNA sequencing and electronic probes as a transcriptomic screening tool. [PDF]

PLoS ONE, 2018
E-probe Diagnostic for Nucleic acid Analysis (EDNA) is a bioinformatic tool originally developed to detect plant pathogens in metagenomic databases. However, enhancements made to EDNA increased its capacity to conduct hypothesis directed detection of ...
Andres S Espindola, William Schneider, Kitty F Cardwell, Yisel Carrillo, Peter R Hoyt, Stephen M Marek, Hassan A Melouk, Carla D Garzon   +7 more
doaj   +1 more source

Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway. [PDF]

, 2015
The ability to biosynthetically produce chemicals beyond what is commonly found in Nature requires the discovery of novel enzyme function. Here we utilize two approaches to discover enzymes that enable specific production of longer-chain (C5-C8) alcohols
Baker, David, Bertolani, Steve, Liao, James C, Mak, Wai Shun, Marcheschi, Ryan, Siegel, Justin B, Thompson, James, Tran, Stephen   +7 more
core   +1 more source

The Nucleic Acid Database: Present and future

Journal of Research of the National Institute of Standards and Technology, 1996
The Nucleic Acid Database is a relational database containing information about three-dimensional nucleic acid structures. The methods used for data processing, structure validation, database management and information retrieval, as well as the various services available via the World Wide Web, are described.
Berman, Helen M., Gelbin, Anke, Clowney, Lester, Hsieh, Shu-Hsin, Zardecki, Christine, Westbrook, John   +5 more
openaire   +2 more sources

dbAMEPNI: a database of alanine mutagenic effects for protein–nucleic acid interactions

Database J. Biol. Databases Curation, 2018
Protein–nucleic acid interactions play essential roles in various biological activities such as gene regulation, transcription, DNA repair and DNA packaging. Understanding the effects of amino acid substitutions on protein–nucleic acid binding affinities
Ling Liu, Y. Xiong, Hongyun Gao, Dongqing Wei, Julie C. Mitchell, Xiaolei Zhu   +5 more
semanticscholar   +1 more source

Nucleic acid and antigen detection tests for leptospirosis.

Cochrane Database of Systematic Reviews, 2019
BACKGROUND Early diagnosis of leptospirosis may contribute to the effectiveness of antimicrobial therapy and early outbreak recognition. Nucleic acid and antigen detection tests have the potential for early diagnosis of leptospirosis.
Bada Yang, S. G. de Vries, A. Ahmed, B. J. Visser, Ingeborg M Nagel, R. Spijker, M. Grobusch, R. Hartskeerl, M. Goris, M. Leeflang   +9 more
semanticscholar   +1 more source

Comparison and development of a metagenomic next-generation sequencing protocol for combined detection of DNA and RNA pathogens in cerebrospinal fluid

BMC Infectious Diseases, 2022
Background The purpose of this study was to evaluate different pretreatment, extraction, amplification, and library generation methods for metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) and to develop an efficient procedure ...
Hanfang Jiang, Zhihao Xing, Xiaorong Liu, Qiang Chai, Zefeng Xin, Chunqing Zhu, Ruihong Lin, Xuwen Deng, Dong Cui, HongDan Gao, Dongli Ma   +10 more
doaj   +1 more source

A Molecular Biology Database Digest [PDF]

, 2000
Computational Biology or Bioinformatics has been defined as the application of mathematical and Computer Science methods to solving problems in Molecular Biology that require large scale data, computation, and analysis [18].
Bry, François, Kröger, Peer
core   +2 more sources