Results 31 to 40 of about 36,179 (151)

ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells

Frontiers in Immunology, 2017
Chemotherapy-induced immunogenic cell death can favor dendritic cell (DC) cross-priming of tumor-associated antigens for T cell activation thanks to the release of damage-associated molecular patterns, including ATP.
Mariangela Lecciso, Darina Ocadlikova, Sabina Sangaletti, Sara Trabanelli, Elena De Marchi, Elisa Orioli, Anna Pegoraro, Paola Portararo, Camilla Jandus, Andrea Bontadini, Annarita Redavid, Valentina Salvestrini, Pedro Romero, Mario P. Colombo, Francesco Di Virgilio, Michele Cavo, Elena Adinolfi, Antonio Curti   +17 more
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N-Alkylation of Anthracycline Antibiotics by Natural Sesquiterpene Lactones as a Way to Obtain Antitumor Agents with Reduced Side Effects

Biomedicines, 2021
Anthracycline antitumor antibiotics are one of the promising classes of chemotherapeutic agents for cancer treatment. The main deterrent to their use is high toxicity to a healthy environment, including cumulative cardiotoxicity.
Margarita Neganova, Alexey Semakov, Yulia Aleksandrova, Ekaterina Yandulova, Sergey Pukhov, Lada Anikina, Sergey Klochkov   +6 more
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Carvedilol Attenuates Inflammatory-Mediated Cardiotoxicity in Daunorubicin-Induced Rats

Pharmaceuticals, 2011
Cardiotoxicity, which results from intense cardiac oxidative stress and inflammation, is the main limiting factor of the anthracyclines. Carvedilol, a beta blocker that is used as a multifunctional neurohormonal antagonist, has been shown to act not only
Punniyakoti T. Veeravedu, Makoto Kodama, Vivian Soetikno, Kenji Suzuki, Rajarajan A. Thandavarayan, Kenichi Watanabe, Flori R. Sari, Wawaimuli Arozal, Somasundaram Arumugam, Meilei Harima   +9 more
doaj   +1 more source

Spectrofluorimetric Determination of Daunorubicin Using Terbium-Deferasirox as a Fluorescence Probe [PDF]

شیمی کاربردی روز, 2015
A spectrofluorimetric method is proposed for the determination of Daunorubicin (DNR) based on its quenching effect on the fluorescence intensity of Tb3+- deferasirox (DFX) complex as a fluorescent probe.
جمشید منظوری لشگر, نوید نیائی, جعفر ابوالحسنی   +2 more
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In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells

Brazilian Journal of Medical and Biological Research, 2001
Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors.
P.E. Dorlhiac-Llacer, M.V. Marquezini, O. Toffoletto, R.C.G. Carneiro, R.C. Maranhão, D.A.F. Chamone   +5 more
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Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line

International Journal of Nanomedicine, 2012
Jian Cheng,1,* Lin Cheng,1,* Baoan Chen,1,2 Guohua Xia,1 Chong Gao,1 Huihui Song,1 Wen Bao,1 Qinglong Guo,3 Haiwei Zhang,3 Xuemei Wang41Department of Hematology, Key Medical Disciplines of Jiangsu Province, Zhongda Hospital, Medical School of Southeast ...
Cheng J, Cheng L, Chen B, Xia G, Gao C, Song H, Bao W, Guo Q, Zhang H, Wang X   +9 more
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Anti-CD123 antibody-modified niosomes for targeted delivery of daunorubicin against acute myeloid leukemia

Drug Delivery, 2017
A novel niosomal delivery system was designed and investigated for the targeted delivery of daunorubicin (DNR) against acute myeloid leukemia (AML). Anti-CD123 antibodies conjugated to Mal-PEG2000-DSPE were incorporated into normal niosomes (NS) via a ...
Fu-rong Liu, Hui Jin, Yin Wang, Chen Chen, Ming Li, Sheng-jun Mao, Qiantao Wang, Hui Li   +7 more
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Anthracycline Induced Cardiac Disorders in Childhood Acute Lymphoblastic Leukemia: A Single-Centre, Retrospective, Observational Study

Frontiers in Pharmacology, 2021
Anthracycline-associated cardiotoxicity is frequently seen in cancer survivors years after treatment, but it is rare in patients on chemotherapy. This study aimed to investigate the clinical characteristics of cardiac disorders in children with acute ...
Hui Yu, Yining Qiu, Hui Yu, Zhujun Wang, Jiawei Xu, Yun Peng, Xia Wan, Xiaoyan Wu, Runming Jin, Fen Zhou   +9 more
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Effect of Sodium 2,3-Dimercaptopropane-1-Sulphonate (DMPS) on Chronic Daunorubicin Toxicity in Rabbits: Comparison with Dexrazoxane

Acta Medica, 2002
A possible protective action of DMPS (a dithiol chelating agent) against chronic daunorubicin toxicity in rabbits in comparison with dexrazoxane was investigated.
Radomír Hrdina, Vladimír Geršl, Ivona Klimtová, Tomáš Šimůnek, Yvona Mazurová, Jarmila Macháčková, Michaela Adamcová   +6 more
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Reduced Dose Intensity of Daunorubicin During Remission Induction for Low-Risk Patients With Acute Lymphoblastic Leukemia: A Retrospective Cohort Study of the Chinese Children’s Cancer Group

Frontiers in Oncology, 2022
It is urgently necessary to reduce the adverse effects of chemotherapy while maintaining their cure high rates for children with acute lymphoblastic leukemia (ALL).
Yong Zhuang, Kefei Wu, Xiaofan Zhu, Jiaoyang Cai, Shaoyan Hu, Ju Gao, Hua Jiang, Xiaowen Zhai, Xin Tian, Yongjun Fang, Runming Jin, Qun Hu, Hui Jiang, Ningling Wang, Lirong Sun, Wing Kwan Leung, Minghua Yang, Kaili Pan, Xuedong Wu, Changda Liang, Shuhong Shen, Jie Yu, Xiuli Ju   +22 more
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