mRNA decapping enzyme2 DCP2 expression correlates with progression and prognosis of hepatocellular carcinoma [PDF]
Scientific ReportsmRNA decapping enzyme 2 (DCP2) is a key regulator of mRNA degradation, influencing RNA metabolism and gene expression. While implicated in various diseases, its role in Hepatocellular carcinoma (HCC) remains unclear.
Tianyi Huang +3 more
exaly +7 more sources
Nature Communications, 2018 The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators.
Jacek Jemielity +2 more
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Biochemical analysis of human eIF4E-DCP2 interaction: Implications for the relationship between translation initiation and decapping. [PDF]
PLoS ONEAll eukaryotic mRNAs bear a 7-methylguanosine cap on their 5' end. The 5' cap enables mRNA translation by binding directly to eIF4E; which further recruits other factors and the 40S ribosome.
Zachary F Mandell, Jeff Coller
doaj +5 more sources
G3: Genes, Genomes, Genetics, 2020 The use of transposons to create mutations has been the cornerstone of Drosophila genetics in the past few decades. Second-site mutations caused by transpositions are often devoid of transposons and thereby affect subsequent analyses.
Rakesh Mishra +2 more
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mRNA decapping proteins regulate EIN2-dependent ethylene signaling in arabidopsis [PDF]
Frontiers in Plant ScienceEthylene signaling regulates plant growth and stress adaptation through a well-defined pathway, yet its mechanistic complexity remains underexplored. Here, we identify two mRNA decapping proteins, DCP1 and DCP2, as novel regulators of canonical ethylene ...
Bai Hui Jiang +14 more
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Conserved and divergent features of human mRNA decapping revealed by biochemical reconstitution [PDF]
Nature CommunicationsDecapping is a critical step in mRNA decay, but the mechanisms regulating human decapping enzyme DCP2 remain poorly understood. Here, we reconstitute the human decapping network using full-length recombinant proteins and compare it to the yeast system ...
Eric A. J. Simko +4 more
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Liquid condensates come of age: Nanoscale domains at the crossroads of stress and disease. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Walter NG, Halder B.
europepmc +2 more sources
The 5' Cap Epitranscriptome and Beyond: Natural and Engineered 5' Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies. [PDF]
ChemMedChem5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Dahm GC +3 more
europepmc +2 more sources
Analysis of m7G-related signatures in the tumor immune microenvironment and identification of clinical prognostic regulators in ovarian cancer [PDF]
Frontiers in ImmunologyOvarian cancer (OV) is the most lethal gynecological malignancy in the world. At present, the effect of m7G modification-related genes on the development of ovarian cancer remains unclear. We performed consensus clustering of ovarian cancer samples based
Kunyu Wang +6 more
doaj +2 more sources
Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways [PDF]
eLifeDegradation of many yeast mRNAs involves decapping by the Dcp1:Dcp2 complex. Previous studies on decapping activators Edc3 and Scd6 suggested their limited roles in mRNA decay.
Rakesh Kumar +7 more
doaj +2 more sources