Results 31 to 40 of about 3,123 (186)
Integration of Bulk and Single-Cell RNA Sequencing to Identify RNA Modifications-Related Prognostic Signature in Ovarian Cancer [PDF]
International Journal of General MedicineShaoyu Wang,1– 3 Qiaomei Zheng,1– 3 Lihong Chen1– 3 1Department of Obstetrics and Gynecology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, People’s Republic of China; 2Department of Obstetrics and Gynecology, National ...
Wang S, Zheng Q, Chen L
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Global Profiling of Cellular Substrates of Human Dcp2 [PDF]
Biochemistry, 2020 Decapping is the first committed step in 5'-to-3' RNA decay, and in the cytoplasm of human cells, multiple decapping enzymes regulate the stabilities of distinct subsets of cellular transcripts. However, the complete set of RNAs regulated by any individual decapping enzyme remains incompletely mapped, and no consensus sequence or property is currently ...
Yang Luo +3 more
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Biophysical Studies of Conformational Changes of the Dcp1:Dcp2 mRNA decapping complex
Controlled degradation of messenger RNA (mRNA) is essential for the regulation of gene expression. The removal of the protective 5’ cap structure of eukaryotic mRNA is a central step in this process and it is catalyzed by the Dcp1:Dcp2 decapping complex.
Krempl, Christina
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Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. [PDF]
PLoS ONE, 2012 Long-term tobacco use causes nicotine dependence via the regulation of a wide range of genes and is accompanied by various health problems. Studies in mammalian systems have revealed some key factors involved in the effects of nicotine, including ...
Jing Ren +6 more
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Zdorovʹe Rebenka, 2022 This scientific review deals with the mechanisms of action of cytoplasmic microRNAs, namely post-transcriptional silencing: recruitment of the DCP1-DCP2 decapping complex and disruption of the interaction of mRNA with ribosomes.
A.E. Abaturov, V.L. Babуch
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eLife, 2022 A single Dcp1–Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5′ to 3′ decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive.
Feng He, Chan Wu, Allan Jacobson
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Discovery of cellular substrates of human RNA decapping enzyme Dcp2 using a stapled bicyclic peptide inhibitor [PDF]
, 2020 Dcp2 is an important enzyme that controls the stability of a subset of human cellular RNAs encoding functions such as transcription and immune responses.
Matthew D., Simon +5 more
core +1 more source
Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 In Saccharomyces cerevisiae, mRNA transcripts with premature termination codons are targeted for deadenylation independent decapping and 5' to 3' decay in a quality control pathway termed nonsense-mediated decay (NMD).
Kylie D Swisher, Roy Parker
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Cell Death and Disease, 2021 Non-coding RNAs (ncRNAs) involve in diverse biological processes by post-transcriptional regulation of gene expression. Emerging evidence shows that miRNA-4293 plays a significant role in the development of non-small cell lung cancer.
Qian Zhang +14 more
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A diversified context-based privacy-preserving scheme (DCP2S) for internet of vehicles
Alexandria Engineering Journal, 2023 The integration of cyber-physical systems (CPS) and Internet of vehicles (IoV) improves the solution for safe driving, traffic reduction, assisted navigation, and secure communication, etc. Based on the communication and service demands, the security and privacy requirements of the users vary.
Ala Saleh Alluhaidan +3 more
openaire +2 more sources