Results 91 to 100 of about 60,554,138 (296)
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Genome Sequence of Stenotrophomonas maltophilia PML168, Which Displays Baeyer-Villiger Monooxygenase Activity [PDF]
, 2012 Stenotrophomonas maltophilia PML168 was isolated from Wembury Beach on the English Coast from a rock pool following growth and selection on agar plates.
Muhling, M +23 more
core +1 more source
Scaffolding of long read assemblies using long range contact information
BMC Genomics, 2017 Background Long read technologies have revolutionized de novo genome assembly by generating contigs orders of magnitude longer than that of short read assemblies.
Jay Ghurye +4 more
doaj +1 more source
Advanced Science, EarlyView.An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi +8 more
wiley +1 more source
Scaling short read de novo DNA sequence assembly to gigabase genomes [PDF]
, 2011 The recent advent of massively parallel sequencing technologies has drastically reduced the cost of sequencing, sparking a revolution in whole genome de novo sequencing.
Cook, Jeffrey J.
core
De novo genome assembly tutorial for ANGUS 2019
, 2019 de novo assembly tutorial data modified for ANGUS 2019; corresponding to these lessons:https://angus.readthedocs.io/en/2019/de-novo-genome-assembly.htmlhttps://angus.readthedocs.io/en/2019/de-novo-genome-exploration ...
Mike Lee (4372780)
core +1 more source
ALLPATHS: De novo assembly of whole-genome shotgun microreads [PDF]
Genome Research, 2008 New DNA sequencing technologies deliver data at dramatically lower costs but demand new analytical methods to take full advantage of the very short reads that they produce. We provide an initial, theoretical solution to the challenge of de novo assembly from whole-genome shotgun “microreads.” For 11 genomes of sizes up to 39 Mb, we generated high ...
Butler, J +7 more
openaire +3 more sources
F1000Research, 2018 Genome graphs are emerging as an important novel approach to the analysis of high-throughput human sequencing data. By explicitly representing genetic variants and alternative haplotypes in a mappable data structure, they can enable the improved analysis
Evan Biederstedt +7 more
doaj +1 more source
Advanced Science, EarlyView.Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang +17 more
wiley +1 more source