Results 1 to 10 of about 327,413 (252)
Detecting foldback artifacts in long-reads. [PDF]
BMC GenomicsAbstract Long-read sequencing data is useful for detecting large and complex structural variations; however, technical artifacts can lead to false structural variant calls. In our analyses, we became aware of a foldback artifact in long-read data.
Heinz JM, Meyerson M, Li H.
europepmc +5 more sources
CoLoRd: compressing long reads. [PDF]
Nat Methods, 2022 Abstract The costs of maintaining exabytes of data produced by sequencing experiments every year has become a major issue in today’s genomics. In spite of the increasing popularity of the third generation sequencing, the existing algorithms for compressing long reads exhibit minor advantage over general purpose gzip ...
Kokot M, Gudyś A, Li H, Deorowicz S.
europepmc +4 more sources
CuReSim-LoRM: A Tool to Simulate Metabarcoding Long Reads [PDF]
International Journal of Molecular Sciences, 2023 Ségolène Caboche +2 more
exaly +2 more sources
RoR: Read-over-Read for Long Document Machine Reading Comprehension [PDF]
Findings of the Association for Computational Linguistics: EMNLP 2021, 2021 Accepted as findings of ...
Jing Zhao +6 more
openaire +2 more sources
Proceedings of the 48th International Conference on Parallel Processing, 2019 We present a parallel algorithm and scalable implementation for genome analysis, specifically the problem of finding overlaps and alignments for data from "third generation" long read sequencers. While long sequences of DNA offer enormous advantages for biological analysis and insight, current long read sequencing instruments have high error rates and ...
Marquita Ellis +4 more
openaire +2 more sources
Long reads: their purpose and place [PDF]
Human Molecular Genetics, 2018 In recent years long-read technologies have moved from being a niche and specialist field to a point of relative maturity likely to feature frequently in the genomic landscape. Analogous to next generation sequencing, the cost of sequencing using long-read technologies has materially dropped whilst the instrument throughput continues to increase ...
Pollard, MO +4 more
openaire +3 more sources
long-read-tools.org: an interactive catalogue of analysis methods for long-read sequencing data [PDF]
GigaScience, 2021 Abstract Background The data produced by long-read third-generation sequencers have unique characteristics compared to short-read sequencing data, often requiring tailored analysis tools for tasks ranging from quality control to downstream processing.
Shanika L Amarasinghe +2 more
openaire +3 more sources
NextPolish2: A Repeat-aware Polishing Tool for Genomes Assembled Using HiFi Long Reads [PDF]
Genomics, Proteomics and BioinformaticsShanlin Liu, Depeng Wang, Kai Ye
exaly +2 more sources
Long-read amplicon denoising [PDF]
Nucleic Acids Research, 2019 Abstract Long-read next-generation amplicon sequencing shows promise for studying complete genes or genomes from complex and diverse populations. Current long-read sequencing technologies have challenging error profiles, hindering data processing and incorporation into downstream analyses.
Venkatesh Kumar +12 more
openaire +2 more sources
Nanopore long-read sequencing of circRNAs [PDF]
Methods, 2021 Circular RNA (circRNA) is a group of highly stable RNA molecules with suggested roles in development and disease. They derive from linear pre-mRNAs when a 5'-splice site splices back to an upstream 3'-splice site in a process termed back-splicing. Most circRNAs are multi-exonic and may contain several thousand nucleotides.
Rahimi, Karim +3 more
openaire +3 more sources