Results 211 to 220 of about 34,246 (233)

DEAD-Box RNA Helicases as Transcription Cofactors

2012
It is established that several DEAD box RNA helicases perform multiple functions in the cell, often through interactions with different partner proteins in a context-dependent manner. Several studies have shown that some DEAD box proteins play important roles as regulators of transcription, particularly as coactivators or cosuppressors of transcription
Fuller-Pace, Frances V., Nicol, Samantha M.   +1 more
openaire   +3 more sources

Signaling to the DEAD box—Regulation of DEAD-box p68 RNA helicase by protein phosphorylations

Cellular Signalling, 2005
P68 nuclear RNA helicase is essential for normal cell growth. The protein plays a very important role in cell development and proliferation. However, the molecular mechanism by which the p68 functions in cell developmental program is not clear. We previously observed that bacterially expressed his-p68 was phosphorylated at multiple sites including ...
Liuqing, Yang, Chunru, Lin, Zhi-Ren, Liu
openaire   +2 more sources

eIF4A: The godfather of the DEAD box helicases

2002
eIF4A has long been considered the "gold standard" for DEAD box helicases. In large measure, this reflected two items: first, the role of eIF4A in protein synthesis initiation was relatively well established. Second, a wide variety of biochemical studies had established the ability of eIF4A to bind nucleic acids in an ATP-dependent manner, to hydrolyze
George W, Rogers, Anton A, Komar, William C, Merrick   +2 more
openaire   +2 more sources

Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpA

Journal of Molecular Biology, 2006
The Escherichia coli DEAD-box protein A (DbpA) belongs to the highly conserved superfamily-II of nucleic acid helicases that play key roles in RNA metabolism. A central question regarding helicase activity is whether the process of coupling ATP hydrolysis to nucleic acid unwinding requires an oligomeric form of the enzyme.
Miguel A, Talavera, Erin E, Matthews, William K, Eliason, Irit, Sagi, Jimin, Wang, Arnon, Henn, Enrique M, De La Cruz   +6 more
openaire   +2 more sources

Looking back on the birth of DEAD-box RNA helicases

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
DEAD-box proteins represent the largest family of RNA helicases, present in all three kingdoms of life. They are involved in a variety of processes involving RNA metabolism and in some instances also in processes that use guide RNAs. Since their first descriptions in the late 1980s, the perception of their molecular activities has dramatically changed.
Linder, Patrick, Fuller-Pace, Frances
openaire   +4 more sources

The DEAD-Box RNA Helicase Dbp5 Functions in Translation Termination

Science, 2007
In eukaryotes, termination of messenger RNA (mRNA) translation is mediated by the release factors eRF1 and eRF3. Using Saccharomyces cerevisiae as a model organism, we have identified a member of the DEAD-box protein (DBP) family, the DEAD-box RNA helicase and mRNA export factor Dbp5, as a ...
Thomas, Gross, Anja, Siepmann, Dorotheé, Sturm, Merle, Windgassen, John J, Scarcelli, Matthias, Seedorf, Charles N, Cole, Heike, Krebber   +7 more
openaire   +2 more sources

DEAD-box helicases: the Yin and Yang roles in viral infections

Biotechnology and Genetic Engineering Reviews, 2018
Viruses hijack the host cell machinery and recruit host proteins to aid their replication. Several host proteins also play vital roles in inhibiting viral replication. Emerging class of host proteins central to both of these processes are the DEAD-box helicases: a highly conserved family of ATP-dependent RNA helicases, bearing a common D-E-A-D (Asp-Glu-
Vanessa Meier-Stephenson, Tyler Mrozowich, Mimi Pham, Trushar R. Patel   +3 more
openaire   +2 more sources

DEAD-box RNA helicases in the multistep process of tumor metastasis

Molecular Biology Reports
RNA helicases constitute a large family of proteins that share a catalytic core with high structural similarity. DEAD-box (DDX) proteins belong to the largest RNA helicase subfamily, and DDX members have been implicated in all facets of RNA metabolism, from transcription to translation, miRNA maturation, and RNA delay and degradation. Interestingly, an
Shan, Li, Tianyu, Feng, Hang, Yuan, Qin, Li, Gang, Zhao, Kai, Li   +5 more
openaire   +2 more sources

Structural basis for the activation of the DEAD-box RNA helicase DbpA by the nascent ribosome

Proceedings of the National Academy of Sciences of the United States of America, 2021
Jan Philip Wurm, Remco Sprangers
exaly  

DEAD-box proteins: the driving forces behind RNA metabolism

Nature Reviews Molecular Cell Biology, 2004
Patrick Linder
exaly