Results 231 to 240 of about 1,397,424 (256)

The Ded1/DDX3 subfamily of DEAD-box RNA helicases

Critical Reviews in Biochemistry and Molecular Biology, 2014
In eukaryotic organisms, the orthologs of the DEAD-box RNA helicase Ded1p from yeast and DDX3 from human form a well-defined subfamily that is characterized by high sequence conservation in their helicase core and their N- and C- termini. Individual members of this Ded1/DDX3 subfamily perform multiple functions in RNA metabolism in both nucleus and ...
Deepak, Sharma, Eckhard, Jankowsky
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The roles of DEAD box helicases in the life cycle of HIV-1

The Lancet, 2015
HIV/AIDS is the largest global public health problem; about 76 million people have been infected with HIV and 36 million people have already died. Existing antiviral treatment is successful but requires lifelong adherence and mostly targets viral factors. The virus mutates and evades both drugs and the human immune response.
Nyarie, Sithole, Claire, Williams, Aisling, Vaughan, Andrew, Lever   +3 more
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A Novel Human Homolog of a Dead-Box RNA Helicase Family

Biochemical and Biophysical Research Communications, 1994
Putative cDNA clones for a nuclear antigen that cross-reacts with anti-human aldolase A monoclonal antibody MAb1A2 were isolated from the HeLa lambda gt11 cDNA library and a candidate clone (clone 3) was analyzed. The cDNA has an open reading frame (ORF) of 1,317 bp encoding a novel RNA helicase belonging to the DEAD RNA helicase family.
Y, Kitajima, H, Yatsuki, R, Zhang, S, Matsuhashi, K, Hori   +4 more
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A DEAD-box RNA helicase in the Escherichia coli RNA degradosome

Nature, 1996
The Escherichia coli RNA degradosome is a multi-enzyme complex that contains the exoribonuclease polynucleotide phosphorylase (PNPase) and the endoribonuclease RNase E. Both enzymes are important in RNA processing and messenger RNA degradation. Here we report that enolase and RhlB are two other major components of the degradosome.
B, Py, C F, Higgins, H M, Krisch, A J, Carpousis   +3 more
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DEAD-box helicases: the Yin and Yang roles in viral infections

Biotechnology and Genetic Engineering Reviews, 2018
Viruses hijack the host cell machinery and recruit host proteins to aid their replication. Several host proteins also play vital roles in inhibiting viral replication. Emerging class of host proteins central to both of these processes are the DEAD-box helicases: a highly conserved family of ATP-dependent RNA helicases, bearing a common D-E-A-D (Asp-Glu-
Vanessa Meier-Stephenson, Tyler Mrozowich, Mimi Pham, Trushar R. Patel   +3 more
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Deciphering the relevance of dead box RNA helicases in gliomagenesis and autophagy

Human Cell
Dead-box RNA helicases (DDXs) are a family of proteins with roles in RNA metabolism, regulating processes such as RNA splicing, translation, and ribosome assembly. Recently, their functions have expanded to include essential roles in autophagy-a cellular degradation pathway crucial for maintaining homeostasis-and oncogenesis, notably in glioblastoma ...
Arpit, Sharma, Naveen, Soni, Megha, Chaudhary, Jingyue, Jia, Bhawana, Bissa   +4 more
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Multiple Functions of the DEAD-Box Helicase Vasa in Drosophila Oogenesis

2017
The DEAD-box helicase Vasa (Vas) has been most extensively studied in the fruit fly, Drosophila melanogaster, and numerous roles for it in germline development have been discovered. Here, we summarize the present state of knowledge about processes during oogenesis that involve Vas, as well as functions of Vas as a maternal determinant of embryonic ...
Mehrnoush, Dehghani, Paul, Lasko
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DEAD-box RNA helicases in the multistep process of tumor metastasis

Molecular Biology Reports
RNA helicases constitute a large family of proteins that share a catalytic core with high structural similarity. DEAD-box (DDX) proteins belong to the largest RNA helicase subfamily, and DDX members have been implicated in all facets of RNA metabolism, from transcription to translation, miRNA maturation, and RNA delay and degradation. Interestingly, an
Shan, Li, Tianyu, Feng, Hang, Yuan, Qin, Li, Gang, Zhao, Kai, Li   +5 more
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Structural basis for the activation of the DEAD-box RNA helicase DbpA by the nascent ribosome

Proceedings of the National Academy of Sciences of the United States of America, 2021
Remco Sprangers, Jan Philip Wurm
exaly  

Characterization of the kinetics of RNA annealing and strand displacement activities of the E. coli DEAD-box helicase CsdA

RNA Biology, 2013
Mads Beich-Frandsen
exaly