Results 221 to 230 of about 20,358 (251)

The DEAD-box protein family of RNA helicases

Gene, 2006
RNA helicases of the DEAD-box protein family have been shown to participate in every aspect of RNA metabolism. They are present in most organisms where they work as RNA helicases or RNPases. The properties of these enzymes in vivo remains poorly described, however some were extensively characterized in vitro, and the solved crystal structures of a few ...
Cordin O, Banroques J, Tanner NK, Linder P   +3 more
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DEAD-Box RNA helicases in animal gametogenesis

Molecular Biology, 2014
This review analyzes and summarizes a current knowledge about a role of RNA helicases in the development and maintenance of gametogenesis of eukaryotic organisms. Here we focused on three representatives of RNA helicase family containing the characteristic motifs in the amino acid sequence (DEAD-box) and carrying substantial and conservative functions ...
A A, Kotov, N V, Akulenko, M V, Kibanov, L V, Olenina   +3 more
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eIF4A: The godfather of the DEAD box helicases

2002
eIF4A has long been considered the "gold standard" for DEAD box helicases. In large measure, this reflected two items: first, the role of eIF4A in protein synthesis initiation was relatively well established. Second, a wide variety of biochemical studies had established the ability of eIF4A to bind nucleic acids in an ATP-dependent manner, to hydrolyze
George W, Rogers, Anton A, Komar, William C, Merrick   +2 more
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Signaling to the DEAD box—Regulation of DEAD-box p68 RNA helicase by protein phosphorylations

Cellular Signalling, 2005
P68 nuclear RNA helicase is essential for normal cell growth. The protein plays a very important role in cell development and proliferation. However, the molecular mechanism by which the p68 functions in cell developmental program is not clear. We previously observed that bacterially expressed his-p68 was phosphorylated at multiple sites including ...
Liuqing, Yang, Chunru, Lin, Zhi-Ren, Liu
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The role of DEAD-box helicases in cardiovascular diseases

Ageing Research Reviews
Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, characterized by complex pathological mechanisms involving myocardial metabolic disorders, vascular dysfunction, and uncontrolled inflammation. DEAD-box (DDX) helicases, a large family of RNA helicases within Superfamily 2 (SF2), are increasingly recognized as ...
Haiyang, Ni, Mingyu, Wang, QiZhu, Tang
openaire   +2 more sources

Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpA

Journal of Molecular Biology, 2006
The Escherichia coli DEAD-box protein A (DbpA) belongs to the highly conserved superfamily-II of nucleic acid helicases that play key roles in RNA metabolism. A central question regarding helicase activity is whether the process of coupling ATP hydrolysis to nucleic acid unwinding requires an oligomeric form of the enzyme.
Miguel A, Talavera, Erin E, Matthews, William K, Eliason, Irit, Sagi, Jimin, Wang, Arnon, Henn, Enrique M, De La Cruz   +6 more
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DEAD-Box RNA Helicases as Transcription Cofactors

2012
It is established that several DEAD box RNA helicases perform multiple functions in the cell, often through interactions with different partner proteins in a context-dependent manner. Several studies have shown that some DEAD box proteins play important roles as regulators of transcription, particularly as coactivators or cosuppressors of transcription
Fuller-Pace, Frances V., Nicol, Samantha M.   +1 more
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Looking back on the birth of DEAD-box RNA helicases

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
DEAD-box proteins represent the largest family of RNA helicases, present in all three kingdoms of life. They are involved in a variety of processes involving RNA metabolism and in some instances also in processes that use guide RNAs. Since their first descriptions in the late 1980s, the perception of their molecular activities has dramatically changed.
Linder, Patrick, Fuller-Pace, Frances
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The Ded1/DDX3 subfamily of DEAD-box RNA helicases

Critical Reviews in Biochemistry and Molecular Biology, 2014
In eukaryotic organisms, the orthologs of the DEAD-box RNA helicase Ded1p from yeast and DDX3 from human form a well-defined subfamily that is characterized by high sequence conservation in their helicase core and their N- and C- termini. Individual members of this Ded1/DDX3 subfamily perform multiple functions in RNA metabolism in both nucleus and ...
Deepak, Sharma, Eckhard, Jankowsky
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Fluorescence Methods in the Investigation of the DEAD-Box Helicase Mechanism

2014
DEAD-box proteins catalyze the ATP-dependent unwinding of RNA duplexes and accompany RNA molecules throughout their cellular life. Conformational changes in the helicase core of DEAD-box proteins are intimately linked to duplex unwinding. In the absence of ligands, the two RecA domains of the helicase core are separated.
Alexandra Z, Andreou, Dagmar, Klostermeier   +1 more
openaire   +2 more sources