Results 191 to 200 of about 15,822 (213)

The Ded1/DDX3 subfamily of DEAD-box RNA helicases

Critical Reviews in Biochemistry and Molecular Biology, 2014
In eukaryotic organisms, the orthologs of the DEAD-box RNA helicase Ded1p from yeast and DDX3 from human form a well-defined subfamily that is characterized by high sequence conservation in their helicase core and their N- and C- termini. Individual members of this Ded1/DDX3 subfamily perform multiple functions in RNA metabolism in both nucleus and ...
Deepak Sharma, Eckhard Jankowsky
exaly   +3 more sources

DEAD-Box RNA helicases in animal gametogenesis

Molecular Biology, 2014
This review analyzes and summarizes a current knowledge about a role of RNA helicases in the development and maintenance of gametogenesis of eukaryotic organisms. Here we focused on three representatives of RNA helicase family containing the characteristic motifs in the amino acid sequence (DEAD-box) and carrying substantial and conservative functions ...
A A, Kotov, N V, Akulenko, M V, Kibanov, L V, Olenina   +3 more
openaire   +2 more sources

DEAD-Box RNA Helicases as Transcription Cofactors

2012
It is established that several DEAD box RNA helicases perform multiple functions in the cell, often through interactions with different partner proteins in a context-dependent manner. Several studies have shown that some DEAD box proteins play important roles as regulators of transcription, particularly as coactivators or cosuppressors of transcription
Fuller-Pace, Frances V., Nicol, Samantha M.   +1 more
openaire   +3 more sources

Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpA

Journal of Molecular Biology, 2006
The Escherichia coli DEAD-box protein A (DbpA) belongs to the highly conserved superfamily-II of nucleic acid helicases that play key roles in RNA metabolism. A central question regarding helicase activity is whether the process of coupling ATP hydrolysis to nucleic acid unwinding requires an oligomeric form of the enzyme.
Miguel A, Talavera, Erin E, Matthews, William K, Eliason, Irit, Sagi, Jimin, Wang, Arnon, Henn, Enrique M, De La Cruz   +6 more
openaire   +2 more sources

A DEAD-box RNA helicase in the Escherichia coli RNA degradosome

Nature, 1996
The Escherichia coli RNA degradosome is a multi-enzyme complex that contains the exoribonuclease polynucleotide phosphorylase (PNPase) and the endoribonuclease RNase E. Both enzymes are important in RNA processing and messenger RNA degradation. Here we report that enolase and RhlB are two other major components of the degradosome.
B, Py, C F, Higgins, H M, Krisch, A J, Carpousis   +3 more
openaire   +2 more sources

Signaling to the DEAD box—Regulation of DEAD-box p68 RNA helicase by protein phosphorylations

Cellular Signalling, 2005
P68 nuclear RNA helicase is essential for normal cell growth. The protein plays a very important role in cell development and proliferation. However, the molecular mechanism by which the p68 functions in cell developmental program is not clear. We previously observed that bacterially expressed his-p68 was phosphorylated at multiple sites including ...
Liuqing, Yang, Chunru, Lin, Zhi-Ren, Liu
openaire   +2 more sources

Looking back on the birth of DEAD-box RNA helicases

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
DEAD-box proteins represent the largest family of RNA helicases, present in all three kingdoms of life. They are involved in a variety of processes involving RNA metabolism and in some instances also in processes that use guide RNAs. Since their first descriptions in the late 1980s, the perception of their molecular activities has dramatically changed.
Linder, Patrick, Fuller-Pace, Frances
openaire   +4 more sources

The DEAD-Box RNA Helicase Dbp5 Functions in Translation Termination

Science, 2007
In eukaryotes, termination of messenger RNA (mRNA) translation is mediated by the release factors eRF1 and eRF3. Using Saccharomyces cerevisiae as a model organism, we have identified a member of the DEAD-box protein (DBP) family, the DEAD-box RNA helicase and mRNA export factor Dbp5, as a ...
Thomas, Gross, Anja, Siepmann, Dorotheé, Sturm, Merle, Windgassen, John J, Scarcelli, Matthias, Seedorf, Charles N, Cole, Heike, Krebber   +7 more
openaire   +2 more sources

DEAD-Box Helicases Form Nucleotide-Dependent, Long-Lived Complexes with RNA

Biochemistry, 2014
DEAD-box RNA helicases bind and remodel RNA and RNA-protein complexes in an ATP-dependent fashion. Several lines of evidence suggest that DEAD-box RNA helicases can also form stable, persistent complexes with RNA in a process referred to as RNA clamping. The molecular basis of RNA clamping is not well understood.
Fei, Liu, Andrea A, Putnam, Eckhard, Jankowsky   +2 more
openaire   +2 more sources

A Novel Human Homolog of a Dead-Box RNA Helicase Family

Biochemical and Biophysical Research Communications, 1994
Putative cDNA clones for a nuclear antigen that cross-reacts with anti-human aldolase A monoclonal antibody MAb1A2 were isolated from the HeLa lambda gt11 cDNA library and a candidate clone (clone 3) was analyzed. The cDNA has an open reading frame (ORF) of 1,317 bp encoding a novel RNA helicase belonging to the DEAD RNA helicase family.
Y, Kitajima, H, Yatsuki, R, Zhang, S, Matsuhashi, K, Hori   +4 more
openaire   +2 more sources