Results 191 to 200 of about 10,578 (207)

Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpA

Journal of Molecular Biology, 2006
The Escherichia coli DEAD-box protein A (DbpA) belongs to the highly conserved superfamily-II of nucleic acid helicases that play key roles in RNA metabolism. A central question regarding helicase activity is whether the process of coupling ATP hydrolysis to nucleic acid unwinding requires an oligomeric form of the enzyme.
Miguel A, Talavera, Erin E, Matthews, William K, Eliason, Irit, Sagi, Jimin, Wang, Arnon, Henn, Enrique M, De La Cruz   +6 more
openaire   +2 more sources

DEAD-Box RNA Helicases as Transcription Cofactors

2012
It is established that several DEAD box RNA helicases perform multiple functions in the cell, often through interactions with different partner proteins in a context-dependent manner. Several studies have shown that some DEAD box proteins play important roles as regulators of transcription, particularly as coactivators or cosuppressors of transcription
Fuller-Pace, Frances V., Nicol, Samantha M.   +1 more
openaire   +3 more sources

Signaling to the DEAD box—Regulation of DEAD-box p68 RNA helicase by protein phosphorylations

Cellular Signalling, 2005
P68 nuclear RNA helicase is essential for normal cell growth. The protein plays a very important role in cell development and proliferation. However, the molecular mechanism by which the p68 functions in cell developmental program is not clear. We previously observed that bacterially expressed his-p68 was phosphorylated at multiple sites including ...
Liuqing, Yang, Chunru, Lin, Zhi-Ren, Liu
openaire   +2 more sources

A Novel Human Homolog of a Dead-Box RNA Helicase Family

Biochemical and Biophysical Research Communications, 1994
Putative cDNA clones for a nuclear antigen that cross-reacts with anti-human aldolase A monoclonal antibody MAb1A2 were isolated from the HeLa lambda gt11 cDNA library and a candidate clone (clone 3) was analyzed. The cDNA has an open reading frame (ORF) of 1,317 bp encoding a novel RNA helicase belonging to the DEAD RNA helicase family.
Y, Kitajima, H, Yatsuki, R, Zhang, S, Matsuhashi, K, Hori   +4 more
openaire   +2 more sources

The DEAD-Box RNA Helicase Dbp5 Functions in Translation Termination

Science, 2007
In eukaryotes, termination of messenger RNA (mRNA) translation is mediated by the release factors eRF1 and eRF3. Using Saccharomyces cerevisiae as a model organism, we have identified a member of the DEAD-box protein (DBP) family, the DEAD-box RNA helicase and mRNA export factor Dbp5, as a ...
Thomas, Gross, Anja, Siepmann, Dorotheé, Sturm, Merle, Windgassen, John J, Scarcelli, Matthias, Seedorf, Charles N, Cole, Heike, Krebber   +7 more
openaire   +2 more sources

Deciphering the relevance of dead box RNA helicases in gliomagenesis and autophagy

Human Cell
Dead-box RNA helicases (DDXs) are a family of proteins with roles in RNA metabolism, regulating processes such as RNA splicing, translation, and ribosome assembly. Recently, their functions have expanded to include essential roles in autophagy-a cellular degradation pathway crucial for maintaining homeostasis-and oncogenesis, notably in glioblastoma ...
Arpit, Sharma, Naveen, Soni, Megha, Chaudhary, Jingyue, Jia, Bhawana, Bissa   +4 more
openaire   +2 more sources

DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei

Experimental Parasitology, 2011
DEAD-box RNA helicase, a putative subunit of the mitochondrial ribosome of Trypanosoma brucei, has been down-regulated in the procyclic and bloodstream stage by RNA interference. Although ablation of the transcript leads to a week growth phenotype in the procyclic cells, the protein does not seem to be essential for mitochondrial translation under ...
Lenka, Richterová, Zuzana, Vávrová, Julius, Lukeš   +2 more
openaire   +2 more sources

DEAD-box RNA helicases in the multistep process of tumor metastasis

Molecular Biology Reports
RNA helicases constitute a large family of proteins that share a catalytic core with high structural similarity. DEAD-box (DDX) proteins belong to the largest RNA helicase subfamily, and DDX members have been implicated in all facets of RNA metabolism, from transcription to translation, miRNA maturation, and RNA delay and degradation. Interestingly, an
Shan, Li, Tianyu, Feng, Hang, Yuan, Qin, Li, Gang, Zhao, Kai, Li   +5 more
openaire   +2 more sources

DEAD-box RNA helicases: The driving forces behind RNA metabolism at the crossroad of viral replication and antiviral innate immunity

Virus Research, 2021
Mohamed A M Ali
exaly  

DEAD box RNA helicases protect Antarctic Pseudomonas syringae Lz4W against oxidative stress

Infection, Genetics and Evolution, 2022
Ashaq Hussain
exaly