Results 71 to 80 of about 15,822 (213)

RNA chaperone activity of DEAD‐box ‘helicase’ proteins

The FASEB Journal, 2013
Cellular RNAs are able to fold to specific functional structures and carry out a host of critical processes despite an inherent propensity of RNA to fold to alternative conformations. In vivo , RNA misfolding is mitigated by RNA chaperones, notably DEAD‐box ‘helicase’ proteins. CYT‐19 is a
Rick Russell, Cynthia Pan, Inga Jarmoskaite   +2 more
openaire   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]

, 2017
DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar, Linden, Martin H., Rudolph, Markus G., Steimer, Lenz, Wurm, Jan Philip, Wöhnert, Jens   +5 more
core  

The two eIF4A helicases in Trypanosoma brucei are functionally distinct [PDF]

, 2006
Protozoan parasites belonging to the family Trypanosomatidae are characterized by an unusual pathway for the production of mRNAs via polycistronic transcription and trans-splicing of a 5' capped mini-exon which is linked to the 3' cleavage and ...
Campbell, Carrington, Caruthers, Caruthers, CHAN, Conti, De Gaudenzi, Dhalia, Gingras, Hirumi, Holzmann, Imataka, Ishigaki, Ivens, Kressler, Lejeune, Lejeune, Li, Li, Liang, Linder, Mair, Marcotrigiano, Minshall, Nielsen, Oberer, Palacios, Pause, Perry, Pestova, Pestova, Preiss, Rocak, Roditi, SHIBUYA, Skeiky, Skeiky, Sonenberg, Story, Svitkin, TANGE, Tanner, von der Haar, Webb, Wickstead, Wirtz, Yang, Yoder-Hill   +47 more
core   +1 more source

The DEAD-Box RNA Helicase Ded1 Is Associated with Translating Ribosomes

Genes, 2023
DEAD-box RNA helicases are ATP-dependent RNA binding proteins and RNA-dependent ATPases that possess weak, nonprocessive unwinding activity in vitro, but they can form long-lived complexes on RNAs when the ATPase activity is inhibited. Ded1 is a yeast DEAD-box protein, the functional ortholog of mammalian DDX3, that is considered important for the ...
Yeter-Alat, Hilal, Belgareh-Touzé, Naïma, Huvelle, Emmeline, Banroques, Josette, Tanner, N   +4 more
openaire   +2 more sources

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

DEAD-Box RNA Helicase Family in Physic Nut (Jatropha curcas L.): Structural Characterization and Response to Salinity

Plants
Helicases, motor proteins present in both prokaryotes and eukaryotes, play a direct role in various steps of RNA metabolism. Specifically, SF2 RNA helicases, a subset of the DEAD-box family, are essential players in plant developmental processes and ...
Rahisa Helena da Silva, Manassés Daniel da Silva, José Ribamar Costa Ferreira-Neto, Bruna de Brito Souza, Francielly Negreiros de Araújo, Elvia Jéssica da Silva Oliveira, Ana Maria Benko-Iseppon, Antonio Félix da Costa, Éderson Akio Kido   +8 more
doaj   +1 more source

Genome-wide identification, in silico characterization and expression analysis of the RNA helicase gene family in chickpea (C. arietinum L.)

Scientific Reports, 2022
The RNA helicases are an important class of enzymes which are known to influence almost every aspect of RNA metabolism. The majority of RNA helicases belong to the SF2 (superfamily 2) superfamily, members of which are further categorized into three ...
Sheel Yadav, Yashwant K. Yadava, Deshika Kohli, Shashi Meena, Gopal Kalwan, C. Bharadwaj, Kishor Gaikwad, Ajay Arora, P. K. Jain   +8 more
doaj   +1 more source

Helicase: A genetic tool for providing stress tolerance in plants

Plant Stress, 2023
Alteration of stress (abiotic and biotic) constitutes one of the major problems for normal plants health. In the present scenario, new molecular tools are broadly utilized to improve stress tolerance and high-yielding crop plants.
Monalisha Das Mohapatra, Sowmya Poosapati, Ranjan Kumar Sahoo, Durga Madhab Swain   +3 more
doaj   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source