Results 21 to 30 of about 2,208 (222)

Reciprocal interactions between tumor and endothelial cells: Effects of selective vasopressin V2 receptor peptide agonists [PDF]

, 2014
Recent experimental evidence suggested that the synthetic peptide desmopressin (DDAVP) interferes tumor angiogenesis by inducing the formation of angiostatin.
Alonso, Daniel Fernando, Garona, Juan
core   +1 more source

Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus

The FASEB Journal, Volume 36, Issue 11, November 2022., 2022
Abstract Water homeostasis is tightly regulated by the kidneys via the process of urine concentration. During reduced water intake, the antidiuretic hormone arginine vasopressin (AVP) binds to the vasopressin receptor type II (V2R) in the kidney to enhance countercurrent multiplication and medullary osmolality, and increase water reabsorption via ...
Federica Petrillo, Dmitry Chernyakov, Cristina Esteva‐Font, Søren B. Poulsen, Bayram Edemir, Robert A. Fenton   +5 more
wiley   +1 more source

Desmopressin responsiveness by age in type 1 von Willebrand disease

Research and Practice in Thrombosis and Haemostasis, 2020
Background Patients with type 1 von Willebrand disease (VWD) undergo a desmopressin (DDAVP) responsiveness challenge at diagnosis to assess whether DDAVP reverses their coagulation deficits.
Nicola Goldberg, Rosane Nisenbaum, Hong Song, David Lillicrap, Jerome Teitel, Paula James, Michelle Sholzberg   +6 more
doaj   +1 more source

Synthetic Vasopressin and Oxytocin Analogs and Their Potential Use in Hemorrhagic, Traumatic and Septic Shock: A Personal Perspective [PDF]

, 2017
As one of us has stated many years ago, “shock is a significant and sustained loss of effective circulating blood volume. It will eventuate in hypoperfusion of critical peripheral tissues, thus leading to a deficit in transcapillary exchange function in ...
Altura BM, Carella A, Gebrewold A, Altura BT   +3 more
core   +1 more source

Preclinical efficacy of [V 4 Q 5 ]dDAVP, a second generation vasopressin analog, on metastatic spread and tumor-associated angiogenesis in colorectal cancer [PDF]

, 2018
Purpose Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V 4 Q 5 ]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma tumors.
Alonso, Daniel Fernando, Garona, Juan, Gomez, Daniel Eduardo, Pifano, Marina, Ripoll, Giselle Vanina, Segatori, Valeria Inés, Sobol, Natasha Tatiana   +6 more
core   +1 more source

Quantification of the relationship between desmopressin concentration and Von Willebrand factor in Von Willebrand disease type 1: A pharmacodynamic study

Haemophilia, Volume 28, Issue 5, Page 814-821, September 2022., 2022
Abstract Introduction Desmopressin can be used to prevent bleeding in von Willebrand disease (VWD), but the relationship between desmopressin and von Willebrand factor activity (VWF:Act) has yet to be quantified. Aim To quantify the relationship between desmopressin dose, its plasma concentration and the VWF:Act response in type 1 VWD patients ...
Jessica M. Heijdra, Michael E. Cloesmeijer, Nico C.B. de Jager, Frank W.G. Leebeek, Marieke H.J.A. Kruip, Marjon H. Cnossen, Ron A.A. Mathôt, for the OPTI‐CLOT/ To WiN study group and SYMPHONY consortium   +7 more
wiley   +1 more source

Practical management of nocturia in urology

Indian Journal of Urology, 2008
Until last decades, nocturia has been considered as an irritative symptom of benign prostatic hyperplasia (BPH), but the nocturia is unresponsive symptoms to various modalities of BPH treatment.
Myeong Heon Jin, Du Geon Moon
doaj   +1 more source

The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models [PDF]

, 2015
Desmopressin (dDAVP) is a safe haemostatic agent with previously reported antitumour activity. It acts as a selective agonist for the V2 vasopressin membrane receptor (V2r) present on tumour cells and microvasculature.
Alonso, Daniel Fernando, Garona, Juan, Gomez, Daniel Eduardo, Iannucci, Nancy Beatriz, Orlando, Ulises Daniel, Ortega, Hugo Hector, Pastrian, María Belén, Pifano, Marina, Podesta, Ernesto Jorge, Ripoll, Giselle Vanina   +9 more
core   +1 more source

Effect of desmopressin on bleeding during endoscopic sinus surgery: A randomized clinical trial

Laryngoscope Investigative Otolaryngology, Volume 7, Issue 4, Page 920-927, August 2022., 2022
Abstract Background This study aimed to evaluate the effect of local nasal desmopressin premedication on blood loss and the quality of surgical field in Functional Endoscopic Sinus Surgery (FESS). Material and methods In a randomized clinical trial, patients referred for FESS to treat their bilateral chronic rhinosinusitis were recruited.
Maliheh Akbarpour, Mir Mohammad Jalali, Maryam Akbari, Soudabeh Haddadi, Ghaffar Fani   +4 more
wiley   +1 more source

Does Desmopressin Reduce Intraoperative Bleeding in Patients Who Undergo Nasal Surgery? A Systematic Review and Meta-Analysis [PDF]

Journal of Rhinology
Background and Objectives This study aimed to determine the efficacy of prophylactic desmopressin administered via the intranasal or intravenous route in reducing intraoperative bleeding during nasal surgery.
Sun Hong Kim, Ah Young Bae, Do Hyun Kim, Se Hwan Hwang   +3 more
doaj   +1 more source