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The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis. [PDF]

Cell Death Dis
Holloway J, Seeley A, Cobbe N, Turkington RC, Longley DB, Evergren E.   +5 more
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The Death Receptors

1999
In recent years apoptosis, also called programmed cell death, has been recognized to be the physiological way for a nucleated animal cell to die. Apoptosis takes care of unwanted, injured or virus-infected cells (Farber 1994; Collins 1995). Autoreactive T and B cells that are produced by the immune system by the millions every day are also eliminated ...
Peter, M. E., Scaffidi, C., Medema, J. P., Kischkel, F., Krammer, P. H.   +4 more
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Death Receptors and Apoptosis

Dermatologic Clinics, 2007
Interactions between death receptors from the tumor necrosis factor superfamily and their ligands play a crucial role in the development and the integrity of the epidermis. The major consequence resulting from death receptor targeting is apoptosis.
Contassot E, Gaide O, French LE
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Death receptors

Essays in Biochemistry, 2003
Death receptors [Fas/Apo-1/CD95, TNF-R1 [tumour necrosis factor (TNF) receptor 1], DR3 [death receptor 3], TRAIL-R1 [TNF-related apoptosis-inducing ligand receptor 1], TRAIL-R2, DR6, p75-NGFR [p75-nerve growth factor receptor], EDAR [ectodermal dysplasia receptor]] form a subgroup of the TNF-R superfamily that can induce apoptosis (programmed cell ...
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Apoptosis induced by death receptors

Pharmaceutica Acta Helvetiae, 2000
Death receptors belong to the TNF receptor family and are characterised by an intracellular death domain that serves to recruit adapter proteins such as TRADD and FADD and cysteine proteases such as Caspase-8. Activation of Caspase-8 on the aggregated receptor leads to apoptosis. Triggering of death receptors is mediated through the binding of specific
Schneider P, Tschopp J
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Death Receptor Ligands in Tumors

Journal of Immunotherapy, 2002
Activation of apoptosis via death receptors is a tightly regulated event, and the death pathway itself is open to interference on the part of soluble or membrane-bound decoy receptors. The aggregation state of the death-inducing ligand is a crucial factor, particularly when these molecules are used as recombinant drugs against tumors.
Paola, Cappello, Francesco, Novelli, Guido, Forni, Mirella, Giovarelli   +3 more
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Death Receptors: Signaling and Modulation

Science, 1998
REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface.
A, Ashkenazi, V M, Dixit
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Death Receptor Signaling and Autoimmunity

Immunologic Research, 2003
In recent years, it has become clear that self-nonself discrimination by the immune system is driven not so much by the specificities of the antigen receptors themselves, but by ligand-receptor systems that sense the presence of foreign pathogens (toll-like receptors) and those that regulate the balance between cellular proliferation and programmed ...
Richard M, Siegel, Jagan, Muppidi, Margaret, Roberts, Melissa, Porter, Zhengqi, Wu   +4 more
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Targeting TRAIL death receptors

Current Opinion in Pharmacology, 2008
The natural occurring tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis following binding to the two TRAIL death receptors (DRs). Its recombinant form and monoclonal antibodies against the TRAIL DRs induce cell death in a wide variety of tumor cell lines and xenografts without causing toxicity to normal cells and are ...
C N A M, Oldenhuis, J H, Stegehuis, A M E, Walenkamp, S, de Jong, E G E, de Vries   +4 more
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