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Death Receptor 5 and Neuroproliferation
Cellular and Molecular Neurobiology, 2011Tumor necrosis factor-related apoptosis-inducing ligand or Apo2 ligand is a member of the tumor necrosis factor superfamily of cytokines that induces apoptosis upon binding to its death domain-containing transmembrane receptors, death receptors 4 and 5 (DR4, DR5).
Yanli, Niu +7 more
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Biochemical and Biophysical Research Communications, 2005
Death receptors (DRs) can induce apoptosis by oligomerization with TRAIL, whereas death decoy receptors (DcRs) cannot, due to their lack of functional intracellular death domains. However, it is not known whether DRs and DcRs can interact with one another to form oligomeric complexes prior to TRAIL binding.
Hyun-Wook, Lee +5 more
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Death receptors (DRs) can induce apoptosis by oligomerization with TRAIL, whereas death decoy receptors (DcRs) cannot, due to their lack of functional intracellular death domains. However, it is not known whether DRs and DcRs can interact with one another to form oligomeric complexes prior to TRAIL binding.
Hyun-Wook, Lee +5 more
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Death receptor 3 mediates necroptotic cell death
Cellular and Molecular Life Sciences, 2016Death receptor 3 (DR3) was initially identified as a T cell co-stimulatory and pro-inflammatory molecule, but further studies revealed a more complex role of DR3 and its ligand TL1A. Although being a death receptor, DR3 gained to date predominantly attention as a contributor to inflammation-driven diseases.
Sebastian Bittner +2 more
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Death receptor‐induced cell death in prostate cancer
Journal of Cellular Biochemistry, 2003AbstractProstate cancer mortality results from metastasis and is often coupled with progression from androgen‐dependent to androgen‐independent growth. Unfortunately, no effective treatment for metastatic prostate cancer increasing patient survival is available. The absence of effective therapies reflects in part a lack of knowledge about the molecular
Natalya V, Guseva +3 more
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Structural Studies of Death Receptors
2014This chapter describes reports of the structural characterization of death ligands and death receptors (DRs) from the tumor necrosis factor (TNF) and TNF receptor families. The review discusses the interactions of these proteins with agonist ligands, inhibitors, and downstream signaling molecules.
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2009
The TNF receptor superfamily is a large group of membrane-associated receptors characterized by structural similarities in their extracellular and intracellular domains. A subgroup of these receptors, the so-called death receptors, shares an intracellular motif termed the death domain.
Maria Eugenia Guicciardi +1 more
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The TNF receptor superfamily is a large group of membrane-associated receptors characterized by structural similarities in their extracellular and intracellular domains. A subgroup of these receptors, the so-called death receptors, shares an intracellular motif termed the death domain.
Maria Eugenia Guicciardi +1 more
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Death receptors and their ligands
2000The identification and description of an intrinsic program of regulated cellular suicide or apoptosis was originally obtained from morphological analyses in developmental biology (76, 77). This program exists in all multicellular organisms, and genetic analyses in the nematode Caenorhabditis elegans identified three ced-genes (for C.
Jürgen Holtz, Dorothea Darmer
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Chemical & Engineering News Archive, 2013
Receptors for the neurotransmitter serotonin are distributed throughout nearly every organ system in the body, and they are the targets of drugs to treat innumerable problems, including depression, migraines, and obesity. Drug designers do their best to craft molecules that zero in on individual serotonin receptors (also known as 5-HTs).
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Receptors for the neurotransmitter serotonin are distributed throughout nearly every organ system in the body, and they are the targets of drugs to treat innumerable problems, including depression, migraines, and obesity. Drug designers do their best to craft molecules that zero in on individual serotonin receptors (also known as 5-HTs).
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The Death Receptor Pathway of Apoptosis
Cold Spring Harbor Perspectives in Biology, 2022openaire +2 more sources