Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs
Cell Reports, 2019 Summary: RNA polymerase II transcripts receive a protective 5ʹ,5ʹ-triphosphate-linked 7-methylguanosine (m7G) cap, and its removal by decapping enzymes like DCP2 is critical for initiation of RNA decay.
Hao Wu +7 more
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Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation [PDF]
, 2021 Cells organize biochemical processes into biological condensates. P-bodies are cytoplasmic condensates that are enriched in enzymes important for mRNA degradation and have been identified as sites of both storage and decay.
Tibble, Ryan W +6 more
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Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus
Molecular Therapy: Oncolytics, 2018 Through the action of two virus-encoded decapping enzymes (D9 and D10) that remove protective caps from mRNA 5′-termini, Vaccinia virus (VACV) accelerates mRNA decay and limits activation of host defenses.
Hannah Burgess +5 more
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Heritability in the efficiency of nonsense-mediated mRNA decay in humans. [PDF]
PLoS ONE, 2010 BACKGROUND: In eukaryotes mRNA transcripts of protein-coding genes in which an intron has been retained in the coding region normally result in premature stop codons and are therefore degraded through the nonsense-mediated mRNA decay (NMD) pathway. There
Cathal Seoighe, Chris Gehring
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Discovery of cellular substrates of human RNA decapping enzyme Dcp2 using a stapled bicyclic peptide inhibitor [PDF]
, 2020 Dcp2 is an important enzyme that controls the stability of a subset of human cellular RNAs encoding functions such as transcription and immune responses.
Matthew D., Simon +5 more
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Coactivator regulation of active site chemistry in the mRNA decapping enzyme Dcp2 [PDF]
, 2014 Regulation of mRNA half-life is a crucial control point of gene expression. Removal of the protective 5' methylguanosine cap is a committed step in the 5'-3' decay pathway, which is carried out by the decapping enzyme Dpc2.
Aglietti, Robin
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mRNA decapping in Saccharomyces cerevisiae
, 2000 The major pathway of mRNA degradation in yeast occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. The products of the DCP1 and DCP2 genes are required for mRNA decapping.
Dunckley, Travis Lee
core +4 more sources
Biology Open, 2016 The rate and regulation of mRNA decay are major elements in the proper control of gene expression. Edc3 and Lsm4 are two decapping activator proteins that have previously been shown to function in the assembly of RNA granules termed P bodies.
Susanne Huch +5 more
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The 'scavenger' m(7)GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast [PDF]
, 2004 Dcs1, the m(7)GpppX pyrophosphatase of Saccharomyces cerevisiae, has been reported to 'scavenge' capped 51 end fragments generated by 3'-->5' mRNA degradation.
Miyan, J +10 more
core +1 more source
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate. [PDF]
PLoS ONE, 2015 Human NUDT16 is a member of the NUDIX hydrolase superfamily. After having been initially described as an mRNA decapping enzyme, recent studies conferred it a role as an "housecleaning" enzyme specialized in the removal of hazardous (deoxy)inosine ...
Lionel Trésaugues +7 more
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