Results 21 to 30 of about 813,296 (157)
Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 In Saccharomyces cerevisiae, mRNA transcripts with premature termination codons are targeted for deadenylation independent decapping and 5' to 3' decay in a quality control pathway termed nonsense-mediated decay (NMD).
Kylie D Swisher, Roy Parker
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, 2022 A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5' to 3' decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive.
Wu, Chan, Jacobson, Allan, He, Feng
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A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs
Biomolecules, 2020 The complexity of the transcriptome is governed by the intricate interplay of transcription, RNA processing, translocation, and decay. In eukaryotes, the removal of the 5’-RNA cap is essential for the initiation of RNA degradation.
Florian Abele +8 more
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The Mimivirus L375 Nudix enzyme hydrolyzes the 5' mRNA cap.
PLoS ONE, 2021 The giant Mimivirus is a member of the nucleocytoplasmic large DNA viruses (NCLDV), a group of diverse viruses that contain double-stranded DNA (dsDNA) genomes that replicate primarily in eukaryotic hosts.
Grace Kago, Susan Parrish
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Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p. [PDF]
PLoS Biology, 2010 Intron-containing pre-mRNAs are normally retained and processed in the nucleus but are sometimes exported to the cytoplasm and degraded by the nonsense-mediated mRNA decay (NMD) pathway as a consequence of their inclusion of intronic in-frame termination
Shuyun Dong, Allan Jacobson, Feng He
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DDX20: A Multifunctional Complex Protein
Molecules, 2023 DEAD-box decapping enzyme 20 (DDX20) is a putative RNA-decapping enzyme that can be identified by the conserved motif Asp–Glu–Ala–Asp (DEAD). Cellular processes involve numerous RNA secondary structure alterations, including translation initiation ...
Lu He +14 more
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Nature Communications, 2018 The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators.
Jeffrey S. Mugridge +4 more
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Characterization of the African Swine Fever Virus Decapping Enzyme during Infection. [PDF]
J Virol, 2017 African swine fever virus (ASFV) infection is characterized by a progressive decrease in cellular protein synthesis with a concomitant increase in viral protein synthesis, though the mechanism by which the virus achieves this is still unknown.
Quintas A +6 more
europepmc +2 more sources
Eukaryotic mRNA decapping factors: molecular mechanisms and activity
, 2022 Decapping is the enzymatic removal of 5' cap structures from mRNAs in eukaryotic cells. Cap structures normally enhance mRNA translation and stability, and their excision commits an mRNA to complete 5'-3' exoribonucleolytic digestion and generally ends ...
Jacobson, Allan, He, Feng
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Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
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