Results 211 to 220 of about 81,314 (317)

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Differential Hydroxypyruvate Processing by <i>E. coli</i> and <i>P. aeruginosa</i> DXP Synthases Reveals Preferential Xylulose 5-Phosphate Formation by the <i>P. aeruginosa</i> Enzyme. [PDF]

Biochemistry
Henriquez S, Nosal CR, Kramer LJ, Toci EM, Trauth SA, Lott AM, Freel Meyers CL.   +6 more
europepmc   +1 more source

Synthesis of Poly(Itaconate)s With High Monomer Conversion Applying Emulsion Polymerization

Journal of Polymer Science, Volume 63, Issue 6, Page 1284-1296, 15 March 2025.
Itaconic acid and its derivatives are a promising and bio‐based substitute for oil‐based polymers such as acrylates. In this study, the optimization of polymerization of itaconic acid esters is described by applying emulsion polymerization leading to high reaction conversions and low residual monomer contents. ABSTRACT Itaconic acid and its derivatives
S. Charlotte Fischer von Mollard, Nico Ueberschaar, Martin Schreiber, Frank Kamphuis, Stefan Zechel, Martin D. Hager   +5 more
wiley   +1 more source

Direct synthesis of bicyclo[1.1.1]pentane (BCP) boronates from carboxylic acids. [PDF]

Nat Commun
Wang Y, Tang JC, Wu G, West JG.
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Aromatic Residues in Mobile Regions Distal to the Active Site Support the Closed Conformation of <i>E. coli</i> DXPS. [PDF]

Biochemistry
Kramer LJ, Austin SL, Majumdar A, Smith ND, Woodcock HL, Freel Meyers CL.   +5 more
europepmc   +1 more source

Structural and Biochemical Characterization of the Diaminopimelate Epimerase DapF From Pseudomonas aeruginosa PA14

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug‐resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potential target for P.
Philipp Schneider, Claudia Hanko, Konrad Büssow, Stefan Schmelz, Wulf Blankenfeldt   +4 more
wiley   +1 more source

Decarboxylation via a Higher Electronic Excited State Drives LSSmOrange Photoconversion. [PDF]

ACS Phys Chem Au
Seol HS, Luo F, De Zitter E, Nuemket N, Fron E, McFarlane NR, De Vrieze L, Civic J, Postelmans M, Van Bel S, Owada S, Tono K, Tanaka T, Arima T, Noguchi H, Bui TYH, Tanaka R, Hasegawa K, Hirata K, Im D, Araya T, Kimura T, Van Meervelt L, Weik M, Harvey JN, Colletier JP, Iwata S, Nango E, Mizuno H.   +28 more
europepmc   +1 more source

University teaching of mass spectrometry as a key practical technique within the context of a fully integrated, spiral curriculum

Rapid Communications in Mass Spectrometry, EarlyView.
Rationale Mass spectrometry (MS) is introduced to high school students in the UK in many pre‐university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies.
Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart   +3 more
wiley   +1 more source

Biomimetic Synthesis of Seven Halenaquinone Meroterpenoids. [PDF]

J Am Chem Soc
Hart JD, Lawrence JK, Franqui PN, Perrott DR, Yi B, Xi Y, Sumby CJ, Newton CG, George JH.   +8 more
europepmc   +1 more source