Results 231 to 240 of about 51,237 (293)

Development of a Brain‐Penetrant Nurr1 Agonist Tool

open access: yesChemMedChem, Volume 21, Issue 11, 15 June 2026.
Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor   +7 more
wiley   +1 more source

Amine‐Triggered Azabenz‐Annulation of Cyclic Secondary Amine‐Functionalized Perylene Diimides for Dual‐Mode Sensing

open access: yesChemistry – A European Journal, Volume 32, Issue 22, 9 June 2026.
Pictet‐Spengler Intermediate of a cyclic secondary amine perylene diimide undergoing amine‐triggered conversion to azabenz‐annulated perylene diimide, inducing a high‐contrast green‐to‐yellow color change along with fluorescence turn‐on, demonstrating intuitive “safe” to “warning” dual‐mode sensing.
Irene E. Park   +2 more
wiley   +1 more source

Therapeutic potential of acidic cannabinoids: an update. [PDF]

open access: yesJ Cannabis Res
Singh SK   +7 more
europepmc   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Structure-Reactivity Relationships of Oxime-Oxalate/Glyoxylate/Ester Derivatives: Dual Photo/Thermal Initiators for Visible Light Polymerization and Composite Preparation. [PDF]

open access: yesAngew Chem Int Ed Engl
Gao T   +11 more
europepmc   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

open access: yesAngewandte Chemie, Volume 138, Issue 24, 8 June 2026.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco   +6 more
wiley   +1 more source

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