Results 81 to 90 of about 10,347,709 (335)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Decent work in a digital age: a comprehensive review of research and theory

open access: yesCogent Business & Management
Rapid technological change is transforming work, leading to a renewed focus on ‘decent work’. While research on decent work is extensive, its connection to digitalization remains under-explored.
Susanti Saragih   +2 more
doaj   +1 more source

A Study on a New 5S Model of Decent Work Perception

open access: yesSustainability
Decent work promotes decent and productive work opportunities for all genders under conditions of freedom, equality, safety, and human dignity. Despite the growing body of literature on this concept, decent work perception (DWP) measurement still needs ...
Yan Yan   +4 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Older workers and post-retirement employment: A proposed decent work agenda

open access: yesAustralian Journal of Career Development
The United Nation's Sustainable Development Goal 8 (SDG8) emphasizes decent work and the need to generate employment for vulnerable groups such as women, youth, and low-income rural and urban residents.
Jennifer Luke, Peter Mcilveen
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

An empirical study on training and decent work for nonwage workers in Indonesia

open access: yesCogent Social Sciences
Most non-wage workers have jobs that cannot guarantee an escape from poverty. They still choose to work rather than be unemployed despite limited or very long working hours, low income, marginalized, casual and mobile work that is far from decent work ...
Ariusni   +3 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

ACHIEVING "DECENT WORK" IN SOUTH AFRICA?

open access: yesPotchefstroom Electronic Law Journal, 2012
The fundamental goal of the International Labour Organisation is the achievement of decent and productive work for both women and men in conditions of freedom, equity, security and human dignity. The South African government has pledged its commitment to
Tamara Cohen, Luendree Moodley
doaj  

Home - About - Disclaimer - Privacy