Results 151 to 160 of about 10,276 (160)

Self‐recognition through Dectin‐1 exacerbates liver inflammation

Genes to Cells
AbstractDectin‐1 is a well‐characterized C‐type lectin receptor involved in anti‐fungal immunity through the recognition of polysaccharides; however, molecular mechanisms and outcomes initiated through self‐recognition have not been fully understood. Here, we purified a water‐soluble fraction from mouse liver that acts as a Dectin‐1 agonist. To address
Shota Torigoe, Douglas W. Lowman, Toshihiko Sugiki, David L. Williams, Sho Yamasaki   +4 more
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Variation in the Yak Dectin-1 Gene (CLEC7A)

DNA and Cell Biology, 2011
C-type lectin domain family 7, member A (CLEC7A, dectin-1) plays an important role in antifungal immunity and belongs to the family of C-type lectin receptors. Variation in the extended exon 4-6 region of the yak dectin-1 gene (CLEC7A), which encodes the β-glucan recognition domain, was investigated using polymerase chain reaction-single strand ...
Guo, Yang, Huitong, Zhou, Jiang, Hu, Yuzhu, Luo, Jon G H, Hickford   +4 more
openaire   +2 more sources

The Biological Role of Dectin-1 in Immune Response

International Reviews of Immunology, 2007
The identification of antigen-recognizing receptors in the innate immune system significantly helped us to understand the initiation and regulation of the innate immune response. Dectin-1 was recently identified as the most important receptor for beta-glucan.
Lina, Sun, Yong, Zhao
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A critical role of Dectin-1 in hypersensitivity pneumonitis

Inflammation Research, 2015
Hypersensitivity pneumonitis (HP) is a pulmonary disease caused by repeated exposure to various aspiration antigens, including bacteria and fungi. Although TLRs are known to be required for the generation of HP triggered by bacteria, the significance of fungal receptors remains unclear. The present study aimed to investigate whether Dectin-1 and Dectin-
Mari, Higashino-Kameda, Toshiki, Yabe-Wada, Shintaro, Matsuba, Kazuya, Takeda, Kazushi, Anzawa, Takashi, Mochizuki, Koichi, Makimura, Shinobu, Saijo, Yoichiro, Iwakura, Hirohisa, Toga, Akira, Nakamura   +10 more
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Dectin-1 and langerin

Pilz-Beta-Glukane aktivieren die Immunantwort über verschiedene Rezeptoren, darunter C-Typ-Lektin-Rezeptoren (CLRs). Eine besondere Rolle spielt dabei Dectin-1. Frühere Studien deuteten darauf hin, dass der Dectin-1-Signalweg, der zur Interleukinproduktion führt, nur durch Hefepartikel aktiviert werden konnte, indem eine Immunsynapse gebildet wird. Die
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Dectin-1

AfCS-Nature Molecule Pages, 2010
Janet Willment, Gordon Brown
openaire   +1 more source

Dectin-1: a signalling non-TLR pattern-recognition receptor

Nature Reviews Immunology, 2005
Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved in innate immune responses to fungal pathogens. This transmembrane signalling receptor mediates various cellular functions, from fungal binding, uptake and killing, to inducing the production of cytokines and chemokines.
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Dectin-1

2018
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Dectin-1

2012
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[Role of Dectin-1 in innate immunity].

Sheng li ke xue jin zhan [Progress in physiology], 2006
Ce, Yang, Zheng-Guo, Wang, Jian-Xin, Jiang   +2 more
openaire   +1 more source