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Dectin-1 Signaling Update: New Perspectives for Trained Immunity
Frontiers in Immunology, 2022 20.500.12530/87857The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses.
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Dectin-1 escape by fungal dimorphism
Trends in Immunology, 2005Candida albicans, a medically important fungus, exists primarily as yeast and filamentous forms. Its cell wall is rich in beta-glucans, which are recognized by a lectin-like innate immune receptor, Dectin-1. A recent study shows that exposure of glucan, by yeasts but not filaments, determines Dectin-1-dependent uptake by macrophages, and thus ...
Heinsbroek, Sigrid E. M. +2 more
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The Role of Dectin-1 in Antifungal Immunity
Critical Reviews in Immunology, 2004beta-Glucans are structural components of fungal cell walls, which have a stimulatory effect on the immune system. Although a number of receptors for these carbohydrates have been proposed, the recently identified C-type lectin-like receptor, Dectin-1, appears to play a central role.
Jurgen, Herre +3 more
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Annals of the New York Academy of Sciences, 2008
β‐Glucans are naturally occurring carbohydrates that possess immune‐modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of β‐glucan receptors, such as dectin‐1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates.
S. Vicky Tsoni, Gordon D. Brown
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β‐Glucans are naturally occurring carbohydrates that possess immune‐modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of β‐glucan receptors, such as dectin‐1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates.
S. Vicky Tsoni, Gordon D. Brown
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Fungal Recognition by TLR2 and Dectin-1
2008The innate immune system utilizes multiple receptors to recognize fungal pathogens, and the net inflammatory response is controlled by interactions between these receptors. Many fungi are recognized, at least in part, by Toll-like receptor 2 (TLR2) and Dectin-1.
Helen S, Goodridge, David M, Underhill
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The Biological Role of Dectin-1 in Immune Response
International Reviews of Immunology, 2007The identification of antigen-recognizing receptors in the innate immune system significantly helped us to understand the initiation and regulation of the innate immune response. Dectin-1 was recently identified as the most important receptor for beta-glucan.
Lina, Sun, Yong, Zhao
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Cytokine, 2015 Contains fulltext : 151986.pdf (Publisher’s version ) (Open Access)Although it is known that Borrelia species express sugar-like structures on their outer surface, not much is known about the role of these structures in immune ...
Marije Oosting +2 more
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Molecular and functional characterization of human Dectin-1
Experimental Hematology, 2002Dendritic cells (DC) have several unique features that differ from other antigen-presenting cells and that enable them to initiate primary immune responses. The aim of this study was to identify and characterize genes that are differentially expressed in DC generated from CD14+ peripheral blood monocytes in vitro.Using a subtractive cDNA library, we ...
Frank, Grünebach +3 more
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Roles of Dectin-1 in Allergic Airway Inflammation
Critical Reviews in Immunology, 2017Asthma is a chronic allergic inflammatory disease of the airways. The symptoms can be controlled by inhaled corticosteroids together with long-acting β2 agonists in the majority of patients; however, in some patients, their symptoms remain uncontrolled even under intensive treatment.
Koichi, Hirose +2 more
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Increased expression of dectin-1 in nasal polyps
American Journal of Otolaryngology, 2013A fungal etiology has been proposed to underlie severe nasal polyps (NP). Dectin-1 is an innate immune pattern recognition receptor which is involved in the recognition of some pathogenic fungi. We investigated the Dectin-1 levels in NP in order to evaluate the implication of such expression with respect to the development of NP.Normal inferior ...
Jian, Gong +3 more
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