Results 111 to 120 of about 18,918 (210)

Polymorphisms of Dectin-1 and TLR2 Predispose to Invasive Fungal Disease in Patients with Acute Myeloid Leukemia.

PLoS ONE, 2016
BackgroundPatients with acute myeloid leukemia (AML) who undergo induction chemotherapy are at high risk for invasive fungal disease (IFD). Dectin-1, a C-type lectin family member represents one of the most important pattern recognition receptors of the ...
Mike Fischer, Baerbel Spies-Weisshart, Karin Schrenk, Bernd Gruhn, Susan Wittig, Anita Glaser, Andreas Hochhaus, Sebastian Scholl, Ulf Schnetzke   +8 more
doaj   +1 more source

Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo [PDF]

, 2013
Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS.
Brown, Gordon D, Engstad, Rolf, Hoving, Jennifer C, Marakalala, Mohlopheni J, Netea, Mihai G, Williams, David L   +5 more
core   +1 more source

Inhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival

Journal of Inflammation Research, 2021
Ao Ren,1– 3 Zhongqiu Li,1– 3 Xuzhi Zhang,1– 3 Ronghai Deng,1– 3 Yi Ma1– 3 1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Guangdong Provincial ...
Ren A, Li Z, Zhang X, Deng R, Ma Y
doaj  

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma [PDF]

, 2015
Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found in allergens.
Brombacher, Frank, Brown, Gordon D., Chen, Kong, Drummond, Rebecca A., Fierens, Kaat, Hadebe, Sabelo, Junecko, Beth A.Fallert, Kirstein, Frank, Kolls, Jay K., Lambrecht, Bart N., Murray, Graeme, Redelinghuys, Pierre, Reinhart, Todd A., Ryffel, Bernhard, Sajaniemi, Sara, Vautier, Simon, Williams, David L.   +16 more
core   +7 more sources

Pattern recognition: recent insights from Dectin-1

Current Opinion in Immunology, 2009
The beta-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production. Recent identification of the components of these signalling pathways, such as Syk kinase,
Reid, Delyth M, Gow, Neil AR, Brown, Gordon D   +2 more
openaire   +2 more sources

Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes [PDF]

, 2014
Beyond its well-documented role in reproduction, embryogenesis and maintenance of body tissues, vitamin A has attracted considerable attention due to its immunomodulatory effects on both the innate and the adaptive immune responses.
Bräuer, Julia, Hanisch, Anja, Heyl, Kerstin A., Klaile, Esther, Klassert, Tilman E., Mansour, Michael M., Slevogt, Hortense, Tam, Jenny M., Vyas, Jatin M.   +8 more
core   +1 more source

Obesity, Inflammation, Dectin-1 and Exercise Training

Journal of Diabetes & Metabolism, 2018
International ...
Saeidi, Ayoub, Hackney, Anthony C., Arab-Yarmohammadi, Vahid, Moradi, Lida, Pashaei, Saman, Ben Abderrahmane, Abderraouf, Zouhal, Hassane   +6 more
openaire   +3 more sources

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

PLoS Biology, 2018
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which
Maria M M Kaisar, Manuel Ritter, Carlos Del Fresno, Hulda S Jónasdóttir, Alwin J van der Ham, Leonard R Pelgrom, Gabriele Schramm, Laura E Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts   +12 more
doaj   +1 more source

The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation.

PLoS Pathogens
C-type lectin receptors (CLRs) are essential to execute host defense against fungal infection. Nevertheless, a comprehensive understanding of the molecular underpinnings of CLR signaling remains a work in progress.
Zhugui Shao, Li Wang, Limin Cao, Tian Chen, Xin-Ming Jia, Wanwei Sun, Chengjiang Gao, Hui Xiao   +7 more
doaj   +1 more source

Dectin-1 Deficiency and Mucocutaneous Fungal Infections [PDF]

New England Journal of Medicine, 2010
László, Maródi, Melinda, Erdös
openaire   +2 more sources