Results 81 to 90 of about 18,800 (200)

Expression of Functionally Different Dectin-1 Isoforms by Murine Macrophages [PDF]

The Journal of Immunology, 2006
Abstract Dectin-1 is a specific receptor for β-glucans and a major receptor for fungal particles on macrophages (Mφ). It is a type II membrane receptor that has a C-terminal, NK-like, C-type lectin-like domain separated from the cell membrane by a short stalk region and a cytoplasmic immunoreceptor tyrosine-based activation-like motif ...
Heinsbroek, Sigrid, Taylor, Philip R., Rosas, Marcela, Willment, Janet A., Williams, David L., Gordon, Siamon, Brown, Gordon D.   +6 more
openaire   +3 more sources

Glial cytokine modulation improves sleep and circadian disruption in female SAA knock‐in mice of Alzheimer's‐related pathology

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear. METHODS We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPPSAA knock‐in and control mice from 2 to 19 months using ...
Teresa Macheda, Margaret R. Hawkins, Carrie E. Johnson, Madison G. Lapid, Haleigh R. Whitlock, Savannah M. Shepard, MaKayla F. Cox, Kelly N. Roberts, Leke Bytyqi, Heather M. Hash, Omar A Abou El‐Ezz, Mohammed Abou El‐Ezz, Katherina Kohler, Sridhar Sunderam, Bruce F. O'Hara, Linda J. Van Eldik, Michael P. Murphy, Marilyn J. Duncan, Adam D. Bachstetter   +18 more
wiley   +1 more source

Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses.

PLoS ONE, 2016
PurposeTo explore the possibility that inhibiting triggering receptor expressed on myeloid cells-1 (TREM-1) and Dendritic cell-associated C-type lectin-1(Dectin-1) could modulate the innate immune response and alleviate the severity of corneal fungal ...
Jing Zhong, Weilan Huang, Qiuchan Deng, Minhao Wu, Huaili Jiang, Xiaolei Lin, Yifang Sun, Xi Huang, Jin Yuan   +8 more
doaj   +1 more source

Candida albicans Hypha Formation and Mannan Masking of β-Glucan Inhibit Macrophage Phagosome Maturation [PDF]

, 2014
Received 28 August 2014 Accepted 28 October 2014 Published 2 December 2014 This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license. ACKNOWLEDGMENTS We thank Janet Willment, Aberdeen Fungal Group,
Bain, Judith M, Ballou, Elizabeth R., Brown, Alistair J. P., Brown, Gordon D., Erwig, Lars P., Gow, Neil A. R., Lewis, Leanne E., Louw, Johanna, Munro, Carol A., Okai, Blessing, Reid, Delyth, Walker, Louise A., Walls, Catriona A.   +12 more
core   +3 more sources

The role of T cells in sepsis of distinct infectious aetiologies

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu, Bijun Zhu, Wanxin Duan, Ruixiang Kang, Xiangdong Wang, Liyang Li   +5 more
wiley   +1 more source

MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent. [PDF]

, 2012
PURPOSE: This study is aimed at demonstrating the in vivo potential of Gd(III)-loaded glucan particles (Gd-GPs) as magnetic resonance imaging (MRI)-positive agents for labeling and tracking phagocytic cells.
Aime, Silvio, Cutrin, Juan Carlos, De Luca, Elisa, Figueiredo, Sara, Geraldes, Carlos FGC, Moreira, Juao Nuno, Rizzitelli, Silvia, Terreno, Enzo   +7 more
core   +1 more source

Protective Mechanism of Auricularia auricula Polysaccharides Against Acute Alcoholic Liver Injury Is Related to Different Consumption Doses

eFood, Volume 7, Issue 2, April 2026.
The study investigated the protective mechanisms of low‐, medium‐, and high‐dose Auricularia auricula polysaccharide (AAP) against acute alcoholic liver injury (AALI) by correlating hepatic biochemical indices with intestinal flora. ABSTRACT This study investigated the dose‐dependent protective effects of Auricularia auricula polysaccharides (AAP ...
Haili Niu, Fangjia Zhao, Zeyu Hu, Qi Wang, Yuan Li, Ivan Kurtovic, Yahong Yuan, Tianli Yue   +7 more
wiley   +1 more source

Dectin-1 Exerts Dual Control in the Gut [PDF]

Cell Host & Microbe, 2015
Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut.
openaire   +2 more sources

Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Inhaled pretreatment of mouse lungs with immunomodulatory Pam2ODN results in lung epithelial cell epigenetic reprogramming that is associated with attenuation of house dust mite extract (HDM)‐induced cDC2s and moDCs expansion in the lung, causing tolerance against HDM sensitization and restricting Th2‐cell‐induced airway eosinophilic allergic ...
Mbaya Ntita, Celine Shuet Lin Kong, Dalia Hassan, Richa Nayak, Jezreel Pantaleón García, Yongxing Wang, Jichao Chen, Scott E. Evans   +7 more
wiley   +1 more source

Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling

Frontiers in Immunology, 2020
Tissue resident intestinal macrophages are known to exhibit an anti-inflammatory phenotype and produce little pro-inflammatory cytokines upon TLR ligation, allowing symbiotic co-existence with the intestinal microbiota. However, upon acute events such as
Martje N. Erkelens, Gera Goverse, Tanja Konijn, Rosalie Molenaar, Marieke R. Beijer, Jan Van den Bossche, Kyra E. de Goede, Sanne G. S. Verberk, Wouter J. de Jonge, Joke M. M. den Haan, Reina E. Mebius   +10 more
doaj   +1 more source