Results 91 to 100 of about 22,245,271 (149)

Kovalente Aktivierung des C‐Typ Lektins DC‐SIGN

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Wir stellen die ersten kovalenten Aktivatoren eines C‐Typ‐Lektins vor. Mithilfe orthogonaler funktioneller Assays, NMR, MS/MS und computergestützter Modellierung untersuchen wir die Mechanismen eines funktionellen „Electrophile‐first“‐Screenings gegen DC‐SIGN.
Jonathan Lefèbre, Maurice Besch, Noémi Csorba, Kristóf Garami, Zoltán Orgován, Gitta Schlosser, Iris Bermejo, Péter Ábrányi‐Balogh, György M. Keserű, Christoph Rademacher   +9 more
wiley   +1 more source

Covalent Activation of the C‐type Lectin DC‐SIGN

Angewandte Chemie International Edition, Volume 65, Issue 3, 16 January 2026.
We introduce the first covalent activators of a C‐type lectin. Using orthogonal functional assays, NMR, MS/MS, and computational modeling, we delineate mechanisms from a functional electrophile‐first screen on dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN) that yields two modes: N‐hydroxysuccinimide (NHS ...
Jonathan Lefèbre, Maurice Besch, Noémi Csorba, Kristóf Garami, Zoltán Orgován, Gitta Schlosser, Iris Bermejo, Péter Ábrányi‐Balogh, György M. Keserű, Christoph Rademacher   +9 more
wiley   +1 more source

Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2 [PDF]

Glycobiology, 2009
The discovery of several transmembrane receptors expressed by antigen presenting cells, including those that detect and interact with specific sugar moieties on the surface of microbes, has improved our understanding of how immunity against infection is generated.
S Tyler, Hollmig, Kiyoshi, Ariizumi, Ponciano D, Cruz   +2 more
openaire   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation [PDF]

Mucosal Immunology, 2014
How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic inflammation and airway hyper-responsiveness.
Clarke, D L, Davis, N H E, Campion, C L, Foster, M L, Heasman, S C, Lewis, A R, Anderson, I K, Corkill, D J, Sleeman, M A, May, R D, Robinson, M J   +10 more
openaire   +2 more sources

A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.

PLoS ONE, 2015
Fungal infections of the cornea can be sight-threatening and have a worse prognosis than other types of microbial corneal infections. Peptidoglycan recognition proteins (PGLYRP), which are expressed on the ocular surface, play an important role in the ...
Xia Hua, Xiaoyong Yuan, Zhijie Li, Terry G Coursey, Stephen C Pflugfelder, De-Quan Li   +5 more
doaj   +1 more source

Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double‐Blind, and Placebo‐Controlled Trial

Brain and Behavior, Volume 16, Issue 1, January 2026.
In a randomized, double‐blind, placebo‐controlled trial, 50 moderately to severely stressed adults received Restake or placebo for 12 weeks. Psychological outcomes, including anxiety, depression, fatigue, perceived stress, and sleep quality, were evaluated alongside stress‐related biomarkers.
Ahmad Safiyyu'd‐din Hisamuddin, Faiqah Ramli, Teik Kee Leo, Mohamad Shazeli Che Zain, Mei Szin Wong, Mohd Raili Suhaili, Le Jie Lee, Tze Yan Lee   +7 more
wiley   +1 more source

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

PLoS Pathogens, 2019
Invasive candidiasis, mainly caused by Candida albicans, is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients. Innate immune cells express pathogen recognition receptors (PRRs) including C-type lectin-like
Aiysha Thompson, Luke C Davies, Chia-Te Liao, Diogo M da Fonseca, James S Griffiths, Robert Andrews, Adam V Jones, Mathew Clement, Gordon D Brown, Ian R Humphreys, Philip R Taylor, Selinda J Orr   +11 more
doaj   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden, Jason Chai, Tafadzwa T. J. Kufazvinei, Robin P. Choudhury   +3 more
wiley   +1 more source