Results 71 to 80 of about 12,249 (194)

Pathogen Strategies to Evade Innate Immune Response: A Signaling Point of View [PDF]

, 2012
An effective host defense against pathogens requires appropriate recognition of the invading microorganism by immune cells, conducing to an inflammatory process that involves recruitment of leukocytes to the site of infection, activation of ...
Cruz, Maria Teresa, Lopes, Maria Celeste, Neves, Bruno Miguel   +2 more
core   +2 more sources

The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages

Frontiers in Immunology, 2018
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene (AIRE). Patients with AIRE mutations are susceptible to Candida albicans infection and present with
Jose Antonio Tavares de Albuquerque, Pinaki Prosad Banerjee, Pinaki Prosad Banerjee, Angela Castoldi, Royce Ma, Royce Ma, Nuria Bengala Zurro, Leandro Hideki Ynoue, Christina Arslanian, Marina Uchoa Wall Barbosa-Carvalho, Joya Emilie de Menezes Correia-Deur, Fernanda Guimarães Weiler, Magnus Regios Dias-da-Silva, Marise Lazaretti-Castro, Luis Alberto Pedroza, Niels Olsen Saraiva Câmara, Emily Mace, Emily Mace, Jordan Scott Orange, Jordan Scott Orange, Antonio Condino-Neto, Antonio Condino-Neto   +21 more
doaj   +1 more source

Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function

npj Biofilms and Microbiomes, 2021
Bacterial biofilms represent a challenge to the healthcare system because of their resilience against antimicrobials and immune attack. Biofilms consist of bacterial aggregates embedded in an extracellular polymeric substance (EPS) composed of ...
Sonali Singh, Yasir Almuhanna, Mohammad Y. Alshahrani, Douglas W. Lowman, Peter J. Rice, Chris Gell, Zuchao Ma, Bridget Graves, Darryl Jackson, Kelly Lee, Rucha Juarez, Janice Koranteng, Sirina Muntaka, Daniel A. Mitchell, Ana C. da Silva, Farah Hussain, Gokhan Yilmaz, Francesca Mastrotto, Yasuhiko Irie, Paul Williams, David L. Williams, Miguel Cámara, Luisa Martinez-Pomares   +22 more
doaj   +1 more source

Co-regulation of Dectin-1 and TLR2 in inflammatory response of human corneal epithelial cells induced by Aspergillus fumigates [PDF]

International Journal of Ophthalmology, 2016
AIM: To investigate the co-regulation of dendritic cell-associated C-type lectin-1 (Dectin-1), Toll-like receptor 2 (TLR2), and relative chemotactic factors in the Telomease-immortalized human corneal epithelial (THCE) cells after exposure to Aspergillus
Gui-Qiu Zhao, Xue-Yan Qiu, Jing Lin, Qing Li, Li-Ting Hu, Qian Wang, Hui Li   +6 more
doaj   +1 more source

Lectin receptors expressed on myeloid cells [PDF]

, 2016
Lectins recognize a diverse array of carbohydrate structures and perform numerous essential biological functions. Here we focus on only two families of lectins, the Siglecs and C-type lectins.
Brown, Gordon D., Crocker, Paul R.
core   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

PLoS Biology, 2018
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which
Maria M M Kaisar, Manuel Ritter, Carlos Del Fresno, Hulda S Jónasdóttir, Alwin J van der Ham, Leonard R Pelgrom, Gabriele Schramm, Laura E Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts   +12 more
doaj   +1 more source

Eicosanoid control over antigen presenting cells in asthma [PDF]

, 2018
Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that ...
Adelroth, Aliberti, Angeli, Baratelli, Barnes, Barnig, Barrett, Barrett, Betz, Bhattacharya, Blaho, Boniface, Bourdonnay, Brash, Cai, Chang, Chen, Clarke, de, de, Doherty, Draijer, Dullaers, Dwyer, Everts, Fajt, Fedyk, Funk, Gao, Gao, Gauvreau, George, Giannattasio, Goodarzi, Guilliams, Guilliams, Hajek, Hallstrand, Hallstrand, Hamilton, Hammad, Hammad, Hammad, Hammad, Hammad, Hardy, Harizi, Harizi, Harizi, Hattori, Haworth, Hedi, Henderson, Herrerias, Hilkens, Hirai, Huang, Hunter, Idzko, Jaffar, Jaffar, Jandl, Johnston, Kalinski, Kalinski, Kalinski, Kanaoka, Kay, Khare, Khayrullina, Kolodsick, Kool, Kühn, Lambrecht, Lambrecht, Lambrecht, Lamoureux, Lauzon-Joset, Lee, Legler, Leigh, Levy, Levy, Levy, Levy, Levy, Linton, Liu, Lombardi, Lukic, Lundequist, Lynch, Machida, Maher, Manning, Maric, Medoff, Mirchandani, Miyahara, Mori, Murn, Muñoz, Nagao, Nagata, Nakano, Nataraj, Norimoto, Nothacker, Ohta, Okunishi, Oliphant, Oriss, Parameswaran, Pavord, Peters-Golden, Pettipher, Phythian-Adams, Planagumà, Plantinga, Prinz, Raymond, Rieser, Rieser, Robbiani, Rodríguez-Pinto, Rogerio, Roper, Roper, Roper, Rubio, Salimi, Samuchiwal, Samuchiwal, Scandella, Schlitzer, Schuijs, Semmrich, Serhan, Sestini, Sheibanie, Shiraishi, Shirey, Shirey, Snijdewint, Speth, Steinbrink, Sturm, Szczeklik, Tager, Tanaka, Tang, Tang, Tang, Terawaki, Thornton, Tilley, Torres, Torres, Upham, van, van, van, van, van, Vassiliou, Vieira, Walker, Wenzel, Westphalen, Willart, Williams, Xue, Yamabayashi, Yamaguchi, Yamaoka, Yang, Zasłona, Zasłona, Zhou, Zhou, Çelik   +180 more
core   +2 more sources

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Gender-specific effects of genetic variants within Th1 and Th17 cell-mediated immune response genes on the risk of developing rheumatoid arthritis.

PLoS ONE, 2013
The present study was conducted to explore whether single nucleotide polymorphisms (SNPs) in Th1 and Th17 cell-mediated immune response genes differentially influence the risk of rheumatoid arthritis (RA) in women and men.
Rafael Cáliz, Luz María Canet, Carmen Belén Lupiañez, Helena Canhão, Helena Canhão, Alejandro Escudero, Ileana Filipescu, Juana Segura-Catena, María José Soto-Pino, Manuela Expósito-Ruiz, Miguel Ángel Ferrer, Antonio García, Lurdes Romani, Alfonso González-Utrilla, Teresa Vallejo, Eva Pérez-Pampin, Kari Hemminki, Asta Försti, Eduardo Collantes, João Eurico Fonseca, Juan Sainz   +20 more
doaj   +1 more source