Dectin-1 Is Required for Resistance to Coccidioidomycosis in Mice
mBio, 2013 We assessed the role of Dectin-1 in the immune response to the pathogenic fungus Coccidioides, both in vitro and in vivo, using mice with a targeted mutation in Clec7a.
Suganya Viriyakosol +4 more
doaj +1 more source
Cryptococcus gattii alters immunostimulatory potential in response to the environment.
PLoS ONE, 2019 Cryptococcus gattii is a capsular fungal pathogen, which causes life-threatening cryptococcosis in immunocompetent individuals. This emerging pathogen is less likely to be recognized by innate immunity compared to traditional Cryptococcus neoformans ...
Keigo Ueno +6 more
doaj +1 more source
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. [PDF]
PLoS Pathogens, 2019 Invasive candidiasis, mainly caused by Candida albicans, is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients. Innate immune cells express pathogen recognition receptors (PRRs) including C-type lectin-like
Aiysha Thompson +11 more
doaj +1 more source
Superficial mycosis and the immune response elements [PDF]
, 2011 As micoses superficiais são prevalentes em todo o mundo, geralmente ocasionadas por dermatófitos e restritas à camada córnea. A resposta imunológica do hospedeiro às infecções dos fungos dermatófitos depende basicamente das defesas do hospedeiro a ...
BENINI, Luciana Vasconcellos +5 more
core +3 more sources
Neither Dectin-2 nor the Mannose Receptor Is Required for Resistance to Coccidioides immitis in Mice [PDF]
Infection and Immunity, 2014 ABSTRACT We investigated the roles of the mannose receptor (MR) and Dectin-2 in resistance to pulmonary coccidioidomycosis in C57BL/6 (B6) mice and in the interaction of myeloid cells with spherules, using B6 mice with targeted mutations in Mrc1 and Clec4n . Spherules are the tissue
Viriyakosol, Suganya +3 more
openaire +4 more sources
Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.
PLoS ONE, 2012 The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi.
Juan Sainz +8 more
doaj +1 more source
Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors
Frontiers in Microbiology, 2022 Numerous studies have demonstrated the importance of gut bacteria in the development of malignancy, while relatively little research has been done on gut mycobiota.
Lilong Zhang +16 more
doaj +1 more source
Macrophage inducible C-type lectin as a multifunctional player in immunity [PDF]
, 2017 The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,
Axelrod +94 more
core +2 more sources
American Journal of Reproductive Immunology, 2020 AbstractProblemPro‐inflammatory responses of pathogen recognition receptors (PRR) are implicated in preterm delivery (PTD). Dectin‐2 is one PRR recognizing unselective carbohydrate structures; its participation in PTD has never been studied before.Method of studyIn an experimental model, PTD was induced in female pregnant wild‐type (WT) mice and mice ...
Liassidou, Aspasia +7 more
openaire +3 more sources
Identification of Mannose-Capped-Arabinomannan 101-mer as a Potential Influenza Virus Vaccine Adjuvant. [PDF]
Adv Sci (Weinh)Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Zhang YF +5 more
europepmc +2 more sources