Results 51 to 60 of about 12,249 (194)

Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation [PDF]

Mucosal Immunology, 2014
How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic inflammation and airway hyper-responsiveness.
Clarke, D L, Davis, N H E, Campion, C L, Foster, M L, Heasman, S C, Lewis, A R, Anderson, I K, Corkill, D J, Sleeman, M A, May, R D, Robinson, M J   +10 more
openaire   +2 more sources

Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients

Journal of Biomedical Science, 2019
Background Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodies (MoAbs) attenuates HDM ...
Ming-Han Chen, Ming-Ting Huang, Wen-Kuang Yu, Shinn-Shing Lee, Jia-Horng Wang, Ting-Jen R. Cheng, Michael R. Bowman, Shie-Liang Hsieh   +7 more
doaj   +1 more source

Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation.

PLoS ONE, 2012
We have re-investigated the role of the complement system and the non-opsonic pattern recognition receptors dectin-1 and dectin-2 in the recognition of fungal particles by inflammatory neutrophils, monocytes and macrophages.
Jacqueline U McDonald, Marcela Rosas, Gordon D Brown, Simon A Jones, Philip R Taylor   +4 more
doaj   +1 more source

Targeting CBLB as a potential therapeutic approach for disseminated candidiasis [PDF]

, 2016
We thank J.M. Penninger (University of Toronto) for providing Cblb−/− mice, Y. Iwakura (Tokyo University of Science) for providing Clec4n−/− mice, S. Lipkowitz (National Cancer Institute, US National Institutes of Health) for providing Cblb constructs, X.
Brown, Gordon D., Guo, Hui, Langdon, Wallace Y., Li, Belinda T., Ouyang, Song, Rajaram, Murugesan V. S., Rappleye, Chad A., Schlesinger, Larry S., Tang, Juan, Tang, Rong, Tao, Lijian, Xiao, Yun, Zeng, Qiuming, Zhang, Jian, Zhao, Yixia   +14 more
core   +1 more source

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]

, 2019
No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano, Apte, Bill, Blom, Brigida Anna Maiorano, De Vries, Durie, Emilio Bria, Ericsson, Ernesto Rossi, Giampaolo Tortora, Gianluigi Petrone, Giovanni Schinzari, Guido Rindi, Ilaria Grazia Zizzari, Lagouros, Makitie, Maria Antonietta Blasi, Maria Grazia Sammarco, Marianna Nuti, Monica Maria Pagliara, Shaw, Sohn, Vincenzo Fiorentino, Whelchel   +24 more
core   +1 more source

The Dectin-2 family of C-type lectins in immunity and homeostasis

Cytokine, 2009
C-type lectins are a diverse family of proteins which recognize a wide range of ligands. This review focuses on the Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle whose genes are clustered in the telomeric region of the NK-gene cluster on mouse chromosome 6 and human chromosome 12.
Graham, Lisa M., Brown, Gordon D.
openaire   +2 more sources

Vav proteins are key regulators of Card9 signaling for innate antifungal immunity [PDF]

, 2016
Fungal infections are major causes of morbidity and mortality, especially in immunocompromised individuals. The innate immune system senses fungal pathogens through Syk-coupled C-type lectin receptors (CLRs), which signal through the conserved immune ...
Bergmann, H, Bustelo, XR, Habermann, B, Jaeger, M, Johnson, M, Koenig, PA, Kumar, V, Menacho-Márquez, M, Netea, M, Neumann, K, Prazeres da Costa, C, Roth, S, Ruland, J, Tybulewicz, VL, Vanes, L, Yeroslaviz, A   +15 more
core   +5 more sources

Dectin-2 polymorphism associated with pulmonary cryptococcosis in HIV-uninfected Chinese patients [PDF]

Medical Mycology, 2015
Dectin-2 is a C-type lectin receptor that can recognize critical structures of fungi and involve in the host immune response after pulmonary fungal infections. We aimed to investigate the association between Dectin-2 genetic polymorphisms and cryptococcosis among a series of human immunodeficiency virus (HIV)-uninfected Chinese patients.
Xiu-Ping, Hu, Rui-Ying, Wang, Xuan, Wang, Ya-Hui, Cao, Yan-Qiong, Chen, Hua-Zhen, Zhao, Ji-Qin, Wu, Xin-Hua, Weng, Xin-Hua, Gao, Ren-Hua, Sun, Li-Ping, Zhu   +10 more
openaire   +2 more sources

862 Dectin-2, a novel target for tumor macrophage reprogramming in cancer immunotherapy [PDF]

Regular and Young Investigator Award Abstracts, 2021
Background Tumor-associated macrophages (TAMs) are an abundant immune cell population in most cancers that support tumor progression through their immunosuppressive effects. We discovered that TAMs express the pattern recognition receptor Dectin-2 (Clec4n/CLEC6A), an activating C-type lectin receptor (CLR) that binds to high-mannose glycans on fungi ...
Justin Kenkel, Po Ho, Sameera Kongara, Karla Henning, Cindy Kreder, Jess Nolin, Steven Chapin, Marcin Kowanetz, Michael Alonso, Shelley Ackerman, Edgar Engleman, David Dornan   +11 more
openaire   +1 more source

Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation [PDF]

, 2016
Acknowledgements We would like to thank the staff of the animal facility for their support and care for our animals. Funding was provided by the Wellcome Trust (102705) and Medical Research Council (UK) (MR/J004820/1) and a University of Aberdeen ...
Brown, Gordon D, Christofi, Maria, Dambuza, Ivy M, Kerscher, Bernhard, Reid, Delyth M, Willment, Janet A, Yamasaki, Sho   +6 more
core   +2 more sources