Results 31 to 40 of about 12,249 (194)

Involvement of Dectin-2 in Ultraviolet Radiation-Induced Tolerance [PDF]

The Journal of Immunology, 2003
Abstract Hapten sensitization through UV-exposed skin induces hapten-specific tolerance which can be adoptively transferred by injecting T cells into naive recipients. The exact phenotype of the regulatory T cells responsible for inhibiting the immune response and their mode of action remain largely unclear.
Yoshinori, Aragane, Akira, Maeda, Agatha, Schwarz, Tadashi, Tezuka, Kiyoshi, Ariizumi, Thomas, Schwarz   +5 more
openaire   +2 more sources

Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria [PDF]

Immunity, 2014
Mycobacteria possess various immunomodulatory molecules on the cell wall. Mannose-capped lipoarabinomannan (Man-LAM), a major lipoglycan of Mycobacterium tuberculosis, has long been known to have both inhibitory and stimulatory effects on host immunity.
Yonekawa, Akiko, Saijo, Shinobu, Hoshino, Yoshihiko, Miyake, Yasunobu, Ishikawa, Eri, Suzukawa, Maho, Inoue, Hiromasa, Tanaka, Masato, Yoneyama, Mitsutoshi, Oh-hora, Masatsugu, Akashi, Koichi, Yamasaki, Sho   +11 more
openaire   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Dectin-1 and Dectin-2 in innate immunity against fungi [PDF]

International Immunology, 2011
Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are expressed mainly in dendritic cells and macrophages. Dectin-1 recognizes β-glucans with its CRD and transduces signals through its immunoreceptor tyrosine-based activation motif
Shinobu, Saijo, Yoichiro, Iwakura
openaire   +2 more sources

Epidermal Langerhans Cell-Targeted Gene Expression by a Dectin-2 Promoter [PDF]

The Journal of Immunology, 2001
Abstract Despite their critical function as APCs for primary immune responses, dendritic cells (DC) and Langerhans cells (LC) have been rarely used as targets of gene-based manipulation because well-defined regulatory elements controlling LC/DC-specific expression have not been identified.
M, Bonkobara, P K, Zukas, S, Shikano, S, Nakamura, P D, Cruz, K, Ariizumi   +5 more
openaire   +2 more sources

Gene expression analysis of toll like receptor 2 and 4, Dectin-1, Osteopontin and inflammatory cytokines in human dental pulp ex-vivo

BMC Oral Health, 2022
Background Toll like receptors (TLR) 2 and 4 present on innate immune cells of the dental pulp detect cariogenic bacteria. Along with bacteria, C. albicans may also be present in dental caries. The presence of C.
Arshad Hasan, Talat Roome, Mohsin Wahid, Shazia Akbar Ansari, Hira Akhtar, Syeda Neha Ahmed Jilani, Amber Kiyani   +6 more
doaj   +1 more source

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes [PDF]

Journal of Experimental Medicine, 2011
The innate signaling pathways for Th2 immunity activated by inhaled antigens are not well defined. We previously identified Dectin-2 as a receptor for glycans in allergen extracts from the house dust mite Dermatophagoides farinae (Df) that mediates cysteinyl leukotriene (cys-LT) generation from pulmonary CD11c+ cells and from GM-CSF–cultured bone ...
Barrett, Nora A., Rahman, Opu M., Fernandez, James M., Parsons, Matthew W., Xing, Wei, Austen, K. Frank, Kanaoka, Yoshihide   +6 more
openaire   +2 more sources

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2. [PDF]

Sci Rep, 2018
AbstractDectin-2 is a C-type lectin involved in the recognition of several pathogens such as Aspergillus fumigatus, Candida albicans, Schistosoma mansonii, and Mycobacterium tuberculosis that triggers Th17 immune responses. Identifying pathogen ligands and understanding the molecular basis of their recognition is one of the current challenges. Purified
Decout A, Silva-Gomes S, Drocourt D, Blattes E, Rivière M, Prandi J, Larrouy-Maumus G, Caminade AM, Hamasur B, Källenius G, Kaur D, Dobos KM, Lucas M, Sutcliffe IC, Besra GS, Appelmelk BJ, Gilleron M, Jackson M, Vercellone A, Tiraby G, Nigou J.   +20 more
europepmc   +7 more sources

Dectin-2-dependent host defense in mice infected with serotype 3 [PDF]

BMC Immunology, 2016
Streptococcus pneumoniae, a major causative bacterial pathogen of community-acquired pneumonia, possesses a thick polysaccharide capsule. Host defense against this bacterium is mediated by activation of innate immune cells that sense bacterial components.
Akahori, Yukiko, Miyasaka, Tomomitsu, Toyama, Masahiko, Matsumoto, Ikumi, Miyahara, Anna, Zong, Tong, Ishii, Keiko, Kinjo, Yuki, Miyazaki, Yoshitsugu, Saijo, Shinobu, Iwakura, Yoichiro, Kawakami, Kazuyoshi   +11 more
core   +4 more sources

Dectin-2 is critical for phagocyte function and resistance to Paracoccidioides brasiliensis in mice

Medical Mycology, 2023
Abstract Germline-encoded pattern recognition receptors, particularly C-type lectin receptors (CLRs), are essential for phagocytes to sense invading fungal cells. Among CLRs, Dectin-2 (encoded by Clec4n) plays a critical role in the antifungal immune response as it recognizes high-mannose polysaccharides on the fungal cell wall ...
Mariana de Resende Damas Cardoso-Miguel, Pedro Henrique Bürgel, Raffael Júnio Araújo de Castro, Clara Luna Marina, Stephan Alberto de Oliveira, Patrícia Albuquerque, Ildinete Silva-Pereira, Anamélia Lorenzetti Bocca, Aldo Henrique Tavares   +8 more
openaire   +2 more sources