Results 11 to 20 of about 12,249 (194)

The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis. [PDF]

J Interferon Cytokine Res, 2016
Acknowledgments This work was supported by European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) (Fungi in the setting of inflammation, allergy and autoimmune diseases: Translating basic science into clinical practices ‘‘ALLFUN’’) to D.C.I., F.C., C ...
Ifrim DC, Quintin J, Courjol F, Verschueren I, van Krieken JH, Koentgen F, Fradin C, Gow NA, Joosten LA, van der Meer JW, van de Veerdonk F, Netea MG.   +11 more
europepmc   +12 more sources

Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions [PDF]

Diabetes & Vascular Disease Research, 2020
Background: C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi.
Kathrin Thiem, Geerte Hoeke, Enchen Zhou, Anneke Hijmans, Tom Houben, Margien G Boels, Isabel M Mol, Esther Lutgens, Ronit Shiri-Sverdlov, Johan Bussink, Thirumala D Kanneganti, Mariëtte R Boon, Rinke Stienstra, Cees J Tack, Patrick CN Rensen, Mihai G Netea, Jimmy FP Berbée, Janna A van Diepen   +17 more
doaj   +2 more sources

Stimulation of Dectin-1 and Dectin-2 during Parenteral Immunization, but Not Mincle, Induces Secretory IgA in Intestinal Mucosa [PDF]

Journal of Immunology Research, 2018
Induction of a robust and long-lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity.
Alina S. Dzharullaeva, Amir I. Tukhvatulin, Alina S. Erokhova, Alina S. Bandelyuk, Nikita B. Polyakov, Andrey I. Solovyev, Natalia A. Nikitenko, Dmitry V. Shcheblyakov, Boris S. Naroditsky, Denis Y. Logunov, Alexander L. Gintsburg   +10 more
doaj   +2 more sources

Fungal chitin-binding glycoprotein induces Dectin-2-mediated allergic airway inflammation synergistically with chitin. [PDF]

PLoS Pathogens
Although chitin in fungal cell walls is associated with allergic airway inflammation, the precise mechanism underlying this association has yet to be elucidated.
Yasunori Muraosa, Yutaro Hino, Shogo Takatsuka, Akira Watanabe, Emiko Sakaida, Shinobu Saijo, Yoshitsugu Miyazaki, Sho Yamasaki, Katsuhiko Kamei   +8 more
doaj   +2 more sources

A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis. [PDF]

J Infect Dis, 2021
AbstractImmunocompromised patients are highly susceptible to invasive aspergillosis. Herein, we identified a homozygous deletion mutation (507 del C) resulting in a frameshift (N170I) and early stop codon in the fungal binding Dectin-2 receptor, in an immunocompromised patient. The mutated form of Dectin-2 was weakly expressed, did not form clusters at/
Griffiths JS, White PL, Czubala MA, Simonazzi E, Bruno M, Thompson A, Rizkallah PJ, Gurney M, da Fonseca DM, Naglik JR, Ingram W, Wilson K, van de Veerdonk FL, Barnes R, Taylor PR, Orr SJ.   +15 more
europepmc   +9 more sources

CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology [PDF]

Cell Reports, 2018
Summary: The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β and IL ...
Parisa Kalantari, Yoelkys Morales, Emily A. Miller, Luis D. Jaramillo, Holly E. Ponichtera, Marcel A. Wuethrich, Cheolho Cheong, Maria C. Seminario, Joanne M. Russo, Stephen C. Bunnell, Miguel J. Stadecker   +10 more
doaj   +2 more sources

TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals [PDF]

Frontiers in Immunology, 2019
Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses ...
José M. Jiménez, Michelle L. Salazar, Sergio Arancibia, Javiera Villar, Fabián Salazar, Fabián Salazar, Gordon D. Brown, Ed C. Lavelle, Luisa Martínez-Pomares, Jafet Ortiz-Quintero, Sergio Lavandero, Augusto Manubens, María Inés Becker, María Inés Becker   +13 more
doaj   +2 more sources

Role of Dectin-2 in the Phagocytosis of Cryptococcus neoformans by Dendritic Cells. [PDF]

Infect Immun, 2021
The cell walls and capsules of Cryptococcus neoformans , a yeast-type fungal pathogen, are rich in polysaccharides. Dectin-2 is a C-type lectin receptor (CLR) that recognizes high-mannose polysaccharides.
Kitai Y, Sato K, Tanno D, Yuan X, Umeki A, Kasamatsu J, Kanno E, Tanno H, Hara H, Yamasaki S, Saijo S, Iwakura Y, Ishii K, Kawakami K.   +13 more
europepmc   +3 more sources

Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. [PDF]

In Vivo, 2022
Rapid spread of COVID-19 resulted in the revision of the value of ultraviolet C (UVC) sterilization in working spaces. This study aimed at investigating the UVC sensitivity of eighteen malignant and nonmalignant cell lines, the protective activity of sodium ascorbate against UVC, and whether Dectin-2 is involved in UVC sensitivity.Various cell lines ...
Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.   +7 more
europepmc   +3 more sources

Mechanism of pathogen recognition by human dectin-2. [PDF]

J Biol Chem, 2017
Dectin-2, a C-type lectin on macrophages and other cells of the innate immune system, functions in response to pathogens, particularly fungi. The carbohydrate-recognition domain (CRD) in dectin-2 is linked to a transmembrane sequence that interacts with the common Fc receptor γ subunit to initiate immune signaling.
Feinberg H, Jégouzo SAF, Rex MJ, Drickamer K, Weis WI, Taylor ME.   +5 more
europepmc   +5 more sources