Results 21 to 30 of about 12,249 (194)

Dectin-2-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy. [PDF]

mSphere, 2019
Invasive fungal diseases caused by Candida albicans , Cryptococcus neoformans , and Aspergillus fumigatus have mortality rates ranging from 10 to 95%. Individual patient costs may exceed $100,000 in the United States.
Ambati S, Ellis EC, Lin J, Lin X, Lewis ZA, Meagher RB.   +5 more
europepmc   +4 more sources

Dectin-2 mediates phagocytosis of Lactobacillus paracasei KW3110 and IL-10 production by macrophages. [PDF]

Sci Rep, 2021
AbstractLactic acid bacteria (LAB) are most generally used as probiotics and some strains of LAB are known to have anti-inflammatory effects. A specific strain of lactic acid bacteria, Lactobacillus paracasei KW3110 (KW3110), activates macrophages to produce interleukin-10 (IL-10), an anti-inflammatory cytokine; however, the biological mechanism ...
Yoshikawa M, Yamada S, Sugamata M, Kanauchi O, Morita Y.   +4 more
europepmc   +5 more sources

Signalling C-Type Lectins in Antimicrobial Immunity [PDF]

, 2013
Funding: This work was funded by the Wellcome Trust, Medical Research Council and the University of Aberdeen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Brown, Gordon D., Drummond, Rebecca A.
core   +11 more sources

Human macrophage C-type lectin forms a heteromeric receptor complex with Mincle but not Dectin-2. [PDF]

Scand J Immunol, 2022
AbstractMCL, Mincle and Dectin‐2 are C‐type lectin receptors expressed by subsets of myeloid cells, and their genes cluster together in the APLEC/Dectin‐2 gene complex. We have previously shown that MCL and Mincle form a heterodimer in the rat, and others have shown that MCL and Dectin‐2 form a heterodimer in the mouse.
Blankson V, Lobato-Pascual A, Saether PC, Fossum S, Dissen E, Daws MR.   +5 more
europepmc   +5 more sources

Antifungal Liposomes Directed by Dectin-2 Offer a Promising Therapeutic Option for Pulmonary Aspergillosis. [PDF]

mBio, 2021
Invasive aspergillosis (IA) generally results from a pulmonary infection of immunocompromised patients by the common soil organism and opportunistic pathogen Aspergillus fumigatus . The susceptible population has expanded rapidly due to the increased number of cancer patients with immunocompromising chemotherapy and
Ambati S, Ellis EC, Pham T, Lewis ZA, Lin X, Meagher RB.   +5 more
europepmc   +4 more sources

C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidase on Dendritic Cells. [PDF]

PLoS ONE, 2017
C-type lectin receptors (CLRs) recognize pathogen-derived ligands and abnormal self that trigger protective immune responses. However, the precise nature of self ligands recognized by CLRs remains to be determined. Here, we found that Dectin-2 recognizes
Daiki Mori, Kensuke Shibata, Sho Yamasaki   +2 more
doaj   +1 more source

Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

eLife, 2022
C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment, Gordon D Brown, Masamichi Nagae, Sho Yamasaki   +12 more
doaj   +1 more source

Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode [PDF]

, 2015
Texel lambs are known to be more resistant to gastrointestinal nematode (GIN) infection than Suffolk lambs, with a greater ability to limit infection. The objectives of this study were to: 1) profile the whole transcriptome of abomasal lymph node tissue ...
A Pichlmair, A Takaoka, AC Zambon, AFT Amarante, Albin M. Ahmed, AM Ahmed, Amanda Lohan, B Chessa, B Ewing, B Good, B Langmead, Barbara Good, Bojlul Bahar, Bryan Markey, D Coltman, FW Schwaiger, G Sayers, G Sayers, H Kato, H Li, H Poeck, J Buitkamp, J Hellemans, J Mugambi, J Pemberton, Jai Mehta, James P. Hanrahan, JJ Rios, John Browne, M Hassan, M O'Brien, M Stear, M Yoneyama, M Yoneyama, MD Robinson, MD Robinson, NA Barrett, OM Keane, OM Keane, Orla M. Keane, P Baruah, Paul McGettigan, R Cagliani, S Biacchesi, S Kawamoto, S Saijo, S Uematsu, ST Hollmig, Suryaprakash Sambhara, TA Kraus, TE Spencer, Torres Sweeney, Y Inoshima   +52 more
core   +14 more sources

Information transfer in mammalian glycan-based communication

eLife, 2023
Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in the cell.
Felix F Fuchsberger, Dongyoon Kim, Natalia Baranova, Hanka Vrban, Marten Kagelmacher, Robert Wawrzinek, Christoph Rademacher   +6 more
doaj   +1 more source

Interactions that define the arrangement of sugar-binding sites in BDCA-2 and dectin-2 dimers. [PDF]

Glycobiology
Abstract The sugar-binding receptors dectin-2 and blood dendritic cell antigen 2 (BDCA-2) bind oligosaccharide ligands through extracellular carbohydrate-recognition domains (CRDs) and initiate intracellular signaling through Fc receptor γ adapters (FcRγ).
Liu Y, Kim JW, Feinberg H, Cull N, Weis WI, Taylor ME, Drickamer K.   +6 more
europepmc   +4 more sources