Results 41 to 50 of about 12,249 (194)

Dectin-2 recognises mannosylated O-antigens of human opportunistic pathogens and augments lipopolysaccharide activation of myeloid cells [PDF]

, 2016
Lipopolysaccharide (LPS) consists of a relatively conserved region of lipid A and core-oligosaccharide, and a highly variable region of O-antigen polysaccharide.
Akatsuka, Alexandra Wittmann, Aucken, Avril, Bergman, Blasius, Cardile, Carpenter, Carter, Chris Whitfield, Dillon, Dimitra Lamprinaki, Dodgson, Drickamer, Eder, Ewa Katzenellenbogen, Feinberg, Ferwerda, Gantner, García-Vallejo, Gavino, Gordeuk, Gringhuis, Herget, Inagaki, Ishikawa, Ito, Jansson, Jiang, Kanazawa, Katzenellenbogen, Kawai, Kawasaki, Kawasaki, Kazuo Yamamoto, Khanna, Kocharova, Kristian M. Bowles, Kubler-Kielb, Lai, Lin, Liu, Liu, Lugowski, Lukasiewicz, Lutz, Macauley, Mann, McGreal, Mesci, Michalski, Miller, Nagaoka, Nagarjuna, Naoki Matsumoto, Norihito Kawasaki, Norimoto, Olsthoorn, Papadopoulos, Parsons, Pfrengle, Podschun, Prehm, Rick, Robinson, Rudick, Saijo, Sanderson, Sato, Shinobu Saijo, Swierzko, Takashi Nishimura, Taylor, Tichaczek-Goska, Tsolis, van Kooyk, Vinogradov, Yoichiro Iwakura, Yonekawa, Yu, Yuriy A. Knirel, Zamze, Zhao   +82 more
core   +1 more source

Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. [PDF]

J Clin Invest, 2019
Environmental triggers, including those from pathogens, are thought to play an important role in triggering autoimmune diseases, such as vasculitis, in genetically susceptible individuals. The mechanism by which activation of the innate immune system contributes to vessel-specific autoimmunity in vasculitis is not known.
Miyabe C, Miyabe Y, Bricio-Moreno L, Lian J, Rahimi RA, Miura NN, Ohno N, Iwakura Y, Kawakami T, Luster AD.   +9 more
europepmc   +4 more sources

The Dectin-2 family of C-type lectin-like receptors: an update [PDF]

International Immunology, 2013
Myeloid and non-myeloid cells express members of the C-type lectin-like receptor (CTLR) family, which mediate crucial cellular functions during immunity and homeostasis. Of relevance here is the dendritic cell-associated C-type lectin-2 (Dectin-2) family of CTLRs, which includes blood dendritic cell antigen 2 (BDCA-2), dendritic cell immunoactivating ...
Kerscher, Bernhard, Willment, Janet A., Brown, Gordon D.   +2 more
openaire   +3 more sources

Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.

PLoS Pathogens, 2011
C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of T(H)1 and T(H)-17 cellular responses.
Sonja I Gringhuis, Brigitte A Wevers, Tanja M Kaptein, Toni M M van Capel, Bart Theelen, Teun Boekhout, Esther C de Jong, Teunis B H Geijtenbeek   +7 more
doaj   +1 more source

Pattern recognition receptors in antifungal immunity [PDF]

, 2014
We thank the Wellcome Trust for funding this study.Peer reviewedPublisher ...
Brown, Gordon D, Hardison, Sarah E, Plato, Anthony   +2 more
core   +2 more sources

Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine. [PDF]

PLoS ONE, 2013
Although thymus-independent type 2 antigens generally do not undergo Ig class switching from IgM to IgG, pneumococcal polysaccharide vaccine (PPV) induces the production of serotype-specific IgG. How this happens remains unclear, however.
Tomomitsu Miyasaka, Yukiko Akahori, Masahiko Toyama, Namiko Miyamura, Keiko Ishii, Shinobu Saijo, Yoichiro Iwakura, Yuki Kinjo, Yoshitsugu Miyazaki, Kazunori Oishi, Kazuyoshi Kawakami   +10 more
doaj   +1 more source

Transcriptional Regulation of Dectin-2 Promoter in Transgenic Mouse

Journal of Veterinary Medical Science, 2004
Despite a preeminent role of epidermal Langerhans cells (LC) in inducing primary immunity, application of gene-based modification to LC function is limited by lack of well-defined transcription regulatory units that can direct LC-specific gene expression.
Makoto, Bonkobara, Tatsuo, Yudate, Hiroko, Yagihara, Tsukimi, Washizu, Ponciano D, Cruz, Kiyoshi, Ariizumi   +5 more
openaire   +3 more sources

Role of Dectin-2 for Host Defense against Systemic Infection with Candida glabrata [PDF]

Infection and Immunity, 2014
ABSTRACTAlthoughCandida glabratais an important pathogenicCandidaspecies, relatively little is known about its innate immune recognition. Here, we explore the potential role of Dectin-2 for host defense againstC. glabrata. Dectin-2-deficient (Dectin-2−/−) mice were found to be more susceptible toC.
Ifrim, D.C., Ifrim, D.C., Bain, J.M., Reid, D.M., Oosting, M., Oosting, M., Oosting, M., Verschueren, I., Verschueren, I., Gow, N.A., van Krieken, J.H.J.M., van Krieken, J.H.J.M., Brown, G.D., Kullberg, B.J., Kullberg, B.J., Joosten, L.A.B., Joosten, L.A.B., Joosten, L.A.B., van der Meer, J.W.M., van der Meer, J.W.M., Koentgen, F., Erwig, L.P., Quintin, J., Quintin, J., Netea, M.G., Netea, M.G.   +25 more
openaire   +5 more sources

Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin

Biomedical Research, 2021
Antigen-presenting cells express pattern recognition receptors (PRRs), which sense pathogen-associated molecular patterns from microorganisms and lead to the induction of inflammatory responses. C-type lectin receptors (CLRs), the representative PRRs, bind to microbial polysaccharides, among which Dectin-2 and Mincle recognize mannose-containing ...
Hideki, Yamamoto, Chikako, Tomiyama, Ko, Sato, Jun, Kasamatsu, Kazuki, Takano, Aya, Umeki, Nana, Nakahata, Tomomitsu, Miyasaka, Emi, Kanno, Hiromasa, Tanno, Sho, Yamasaki, Shinobu, Saijo, Yoichiro, Iwakura, Keiko, Ishii, Kazuyoshi, Kawakami   +14 more
openaire   +3 more sources

Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition [PDF]

, 2015
Funded by NIH.
Brown, Gordon D, Hardison, Sarah E, Klein, Bruce, Lerksuthirat, Tassanee, Li, Mengyi, Wang, Huafeng, Wüthrich, Marcel   +6 more
core   +1 more source