Fungal chitin-binding glycoprotein induces Dectin-2-mediated allergic airway inflammation synergistically with chitin. [PDF]
PLoS PathogensAlthough chitin in fungal cell walls is associated with allergic airway inflammation, the precise mechanism underlying this association has yet to be elucidated.
Yasunori Muraosa +8 more
doaj +6 more sources
A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis. [PDF]
J Infect Dis, 2021 Immunocompromised patients are highly susceptible to invasive aspergillosis. Herein, we identified a homozygous deletion mutation (507 del C) resulting in a frameshift (N170I) and early stop codon in the fungal binding Dectin-2 receptor, in an ...
Griffiths JS +15 more
europepmc +10 more sources
TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals [PDF]
Frontiers in Immunology, 2019 Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses ...
José M. Jiménez +13 more
doaj +3 more sources
The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species. [PDF]
PLoS ONE, 2019 Phagocytosis is a receptor-mediated process critical to innate immune clearance of pathogens. It proceeds in a regulated sequence of stages: (a) migration of phagocytes towards pathogens, (b) recognition of PAMPs and binding through PRRs, (c) engulfment ...
Mohammed Haider +8 more
doaj +3 more sources
Dectin-2 mediates phagocytosis of Lactobacillus paracasei KW3110 and IL-10 production by macrophages. [PDF]
Sci Rep, 2021 Lactic acid bacteria (LAB) are most generally used as probiotics and some strains of LAB are known to have anti-inflammatory effects. A specific strain of lactic acid bacteria, Lactobacillus paracasei KW3110 (KW3110), activates macrophages to produce ...
Yoshikawa M +4 more
europepmc +6 more sources
Dectin-2-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy. [PDF]
mSphere, 2019 Invasive fungal diseases caused by Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus have mortality rates ranging from 10 to 95%. Individual patient costs may exceed $100,000 in the United States.
Ambati S +5 more
europepmc +5 more sources
Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. [PDF]
In Vivo, 2022 Background/Aim: Rapid spread of COVID-19 resulted in the revision of the value of ultraviolet C (UVC) sterilization in working spaces. This study aimed at investigating the UVC sensitivity of eighteen malignant and nonmalignant cell lines, the protective
Shindo A +7 more
europepmc +4 more sources
Role of Dectin-2 in the Phagocytosis of Cryptococcus neoformans by Dendritic Cells. [PDF]
Infect Immun, 2021 The cell walls and capsules of Cryptococcus neoformans , a yeast-type fungal pathogen, are rich in polysaccharides. Dectin-2 is a C-type lectin receptor (CLR) that recognizes high-mannose polysaccharides.
Kitai Y +13 more
europepmc +4 more sources
Mechanism of pathogen recognition by human dectin-2. [PDF]
J Biol Chem, 2017 Dectin-2, a C-type lectin on macrophages and other cells of the innate immune system, functions in response to pathogens, particularly fungi. The carbohydrate-recognition domain (CRD) in dectin-2 is linked to a transmembrane sequence that interacts with ...
Feinberg H +5 more
europepmc +7 more sources
Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. [PDF]
J Clin Invest, 2019 Environmental triggers, including those from pathogens, are thought to play an important role in triggering autoimmune diseases, such as vasculitis, in genetically susceptible individuals.
Miyabe C +9 more
europepmc +5 more sources