Results 21 to 30 of about 22,245,271 (149)

Antifungal Liposomes Directed by Dectin-2 Offer a Promising Therapeutic Option for Pulmonary Aspergillosis. [PDF]

mBio, 2021
Invasive aspergillosis (IA) generally results from a pulmonary infection of immunocompromised patients by the common soil organism and opportunistic pathogen Aspergillus fumigatus.
Ambati S, Ellis EC, Pham T, Lewis ZA, Lin X, Meagher RB.   +5 more
europepmc   +5 more sources

Candida albicans N-Linked Mannans Potentiate the Induction of Trained Immunity via Dectin-2. [PDF]

J Infect Dis
The interaction between the Candida albicans cell wall and pattern recognition receptors is crucial for the initiation of host immune responses which, ultimately, contribute to the clearance of this pathogenic fungus. In the present study, we investigate
Rosati D, Pradhan A, van Heck JIP, Helder L, Jaeger M, Gow NAR, Joosten LAB, Williams DL, Brown AJP, Bruno M, Netea MG.   +10 more
europepmc   +5 more sources

The intestinal commensal fungus Wallemia mellicola enhances asthma in mice through Dectin-2. [PDF]

Med Mycol
Abstract Overgrowth of the fungus Wallemia mellicola in the intestines of mice enhances the severity of asthma. Wallemia mellicola interacts with the immune system through Dectin-2 expressed on the surface of myeloid and intestinal epithelial cells. Using Dectin-2-deficient mice, we show that the interaction of W. mellicola with Dectin-2
Kanj AN, Guiance IR, Kottom TJ, Schaefbauer KJ, Choudhury M, Limper AH, Skalski JH.   +6 more
europepmc   +4 more sources

Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin.

Biomedical Research, 2021
Antigen-presenting cells express pattern recognition receptors (PRRs), which sense pathogen-associated molecular patterns from microorganisms and lead to the induction of inflammatory responses.
Hideki Yamamoto, C. Tomiyama, Ko Sato, J. Kasamatsu, K. Takano, Aya Umeki, Nana Nakahata, T. Miyasaka, E. Kanno, H. Tanno, S. Yamasaki, S. Saijo, Y. Iwakura, K. Ishii, K. Kawakami   +14 more
semanticscholar   +4 more sources

Stimulation of Dectin-1 and Dectin-2 during Parenteral Immunization, but Not Mincle, Induces Secretory IgA in Intestinal Mucosa [PDF]

Journal of Immunology Research, 2018
Induction of a robust and long-lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity.
Alina S. Dzharullaeva, Amir I. Tukhvatulin, Alina S. Erokhova, Alina S. Bandelyuk, Nikita B. Polyakov, Andrey I. Solovyev, Natalia A. Nikitenko, Dmitry V. Shcheblyakov, Boris S. Naroditsky, Denis Y. Logunov, Alexander L. Gintsburg   +10 more
doaj   +2 more sources

Dectin-2 is critical for phagocyte function and resistance to Paracoccidioides brasiliensis in mice.

Medical Mycology, 2023
Germline-encoded pattern recognition receptors (PRRs), particularly C-type lectin receptors (CLRs), are essential for phagocytes to sense invading fungal cells.
Mariana de Resende Damas Cardoso-Miguel, P. H. Bürgel, R. J. A. de Castro, C. Marina, S. A. D. de Oliveira, Patrícia Albuquerque, I. Silva-Pereira, A. Bocca, A. Tavares   +8 more
semanticscholar   +3 more sources

Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction [PDF]

Circulation Research, 2017
Rationale: Macrophages are involved in wound healing after myocardial infarction (MI). The role of Dectin-2, a pattern recognition receptor mainly expressed on myeloid cells, in the infarct healing remains unknown.
Xiaoxiang Yan, Hang Zhang, Qin Fan, Jian Hu, R. Tao, Qiu Jing Chen, Y. Iwakura, Weifeng Shen, Lin Lu, Qi Zhang, Ruiyan Zhang   +10 more
semanticscholar   +3 more sources

CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology [PDF]

Cell Reports, 2018
Summary: The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β and IL ...
Parisa Kalantari, Yoelkys Morales, Emily A. Miller, Luis D. Jaramillo, Holly E. Ponichtera, Marcel A. Wuethrich, Cheolho Cheong, Maria C. Seminario, Joanne M. Russo, Stephen C. Bunnell, Miguel J. Stadecker   +10 more
doaj   +2 more sources

Human macrophage C-type lectin forms a heteromeric receptor complex with Mincle but not Dectin-2. [PDF]

Scand J Immunol, 2022
MCL, Mincle and Dectin‐2 are C‐type lectin receptors expressed by subsets of myeloid cells, and their genes cluster together in the APLEC/Dectin‐2 gene complex.
Blankson V, Lobato-Pascual A, Saether PC, Fossum S, Dissen E, Daws MR.   +5 more
europepmc   +2 more sources

High-mannose glycans from Schistosoma mansoni eggs are important for priming of Th2 responses via Dectin-2 and prostaglandin E2. [PDF]

Front Immunol
The parasitic helminth Schistosoma mansoni is a potent inducer of type 2 immune responses by stimulating dendritic cells (DCs) to prime T helper 2 (Th2) responses. We previously found that S.
Almeida L, van Roey R, Patente TA, Otto F, Veldhuizen T, Ghorasaini M, van Diepen A, Schramm G, Liu J, Idborg H, Korotkova M, Jakobsson PJ, Giera M, Hokke CH, Everts B.   +14 more
europepmc   +2 more sources