Results 61 to 70 of about 22,245,271 (149)

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2. [PDF]

Sci Rep, 2018
Dectin-2 is a C-type lectin involved in the recognition of several pathogens such as Aspergillus fumigatus, Candida albicans, Schistosoma mansonii, and Mycobacterium tuberculosis that triggers Th17 immune responses.
Decout A, Silva-Gomes S, Drocourt D, Blattes E, Rivière M, Prandi J, Larrouy-Maumus G, Caminade AM, Hamasur B, Källenius G, Kaur D, Dobos KM, Lucas M, Sutcliffe IC, Besra GS, Appelmelk BJ, Gilleron M, Jackson M, Vercellone A, Tiraby G, Nigou J.   +20 more
europepmc   +2 more sources

Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.

PLoS ONE, 2012
The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi.
Juan Sainz, Carmen Belén Lupiáñez, Juana Segura-Catena, Lourdes Vazquez, Rafael Ríos, Salvador Oyonarte, Kari Hemminki, Asta Försti, Manuel Jurado   +8 more
doaj   +1 more source

Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors

Frontiers in Microbiology, 2022
Numerous studies have demonstrated the importance of gut bacteria in the development of malignancy, while relatively little research has been done on gut mycobiota.
Lilong Zhang, Lilong Zhang, Dongqi Chai, Dongqi Chai, Chen Chen, Chunlei Li, Chunlei Li, Zhendong Qiu, Zhendong Qiu, Tianrui Kuang, Tianrui Kuang, Mungur Parveena, Mungur Parveena, Keshuai Dong, Jia Yu, Wenhong Deng, Weixing Wang   +16 more
doaj   +1 more source

The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages

Frontiers in Immunology, 2018
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene (AIRE). Patients with AIRE mutations are susceptible to Candida albicans infection and present with
Jose Antonio Tavares de Albuquerque, Pinaki Prosad Banerjee, Pinaki Prosad Banerjee, Angela Castoldi, Royce Ma, Royce Ma, Nuria Bengala Zurro, Leandro Hideki Ynoue, Christina Arslanian, Marina Uchoa Wall Barbosa-Carvalho, Joya Emilie de Menezes Correia-Deur, Fernanda Guimarães Weiler, Magnus Regios Dias-da-Silva, Marise Lazaretti-Castro, Luis Alberto Pedroza, Niels Olsen Saraiva Câmara, Emily Mace, Emily Mace, Jordan Scott Orange, Jordan Scott Orange, Antonio Condino-Neto, Antonio Condino-Neto   +21 more
doaj   +1 more source

Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function

npj Biofilms and Microbiomes, 2021
Bacterial biofilms represent a challenge to the healthcare system because of their resilience against antimicrobials and immune attack. Biofilms consist of bacterial aggregates embedded in an extracellular polymeric substance (EPS) composed of ...
Sonali Singh, Yasir Almuhanna, Mohammad Y. Alshahrani, Douglas W. Lowman, Peter J. Rice, Chris Gell, Zuchao Ma, Bridget Graves, Darryl Jackson, Kelly Lee, Rucha Juarez, Janice Koranteng, Sirina Muntaka, Daniel A. Mitchell, Ana C. da Silva, Farah Hussain, Gokhan Yilmaz, Francesca Mastrotto, Yasuhiko Irie, Paul Williams, David L. Williams, Miguel Cámara, Luisa Martinez-Pomares   +22 more
doaj   +1 more source

Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

PLoS Biology, 2018
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which
Maria M M Kaisar, Manuel Ritter, Carlos Del Fresno, Hulda S Jónasdóttir, Alwin J van der Ham, Leonard R Pelgrom, Gabriele Schramm, Laura E Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts   +12 more
doaj   +1 more source

Co-regulation of Dectin-1 and TLR2 in inflammatory response of human corneal epithelial cells induced by Aspergillus fumigates [PDF]

International Journal of Ophthalmology, 2016
AIM: To investigate the co-regulation of dendritic cell-associated C-type lectin-1 (Dectin-1), Toll-like receptor 2 (TLR2), and relative chemotactic factors in the Telomease-immortalized human corneal epithelial (THCE) cells after exposure to Aspergillus
Gui-Qiu Zhao, Xue-Yan Qiu, Jing Lin, Qing Li, Li-Ting Hu, Qian Wang, Hui Li   +6 more
doaj   +1 more source

Identification of Mannose‐Capped‐Arabinomannan 101‐mer as a Potential Influenza Virus Vaccine Adjuvant

Advanced Science, EarlyView.
Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang, Ruihong Xu, Jia Luo, Yuxin Ma, Guozhi Xiao, Ye Liu   +5 more
wiley   +1 more source

The C-type Lectin Receptor Dectin-2 is a receptor for Aspergillus fumigatus galactomannan

bioRxiv, 2022
Aspergillus fumigatus is a ubiquitous environmental mold that causes significant mortality particularly amongst immunocompromised patients. The detection of the Aspergillus-derived carbohydrate galactomannan in patient sera and bronchoalveolar lavage ...
J. Reedy, Arianne J. Crossen, Paige E. Negoro, Hannah E. Brown, Rebecca A. Ward, Diego A. Vargas Blanco, Kyle D. Timmer, Michael K. Mansour, Marcel Wüthrich, T. Fontaine, J. Latgé, J. Vyas   +11 more
semanticscholar   +1 more source

The Dectin-2 family of C-type lectins in immunity and homeostasis

Cytokine, 2009
C-type lectins are a diverse family of proteins which recognize a wide range of ligands. This review focuses on the Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle whose genes are clustered in the telomeric region of the NK-gene cluster on mouse chromosome 6 and human chromosome 12.
Graham, Lisa M., Brown, Gordon D.
openaire   +2 more sources