Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children [PDF]
Pharmacology and Clinical Pharmacy Research, 2016 Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients.
Asti Y. Rindarwati +2 more
doaj +1 more source
Cureus, 2023 Despite the established efficacy of iron chelation therapy in transfusion-induced iron-overloaded patients, there is no universal agreement regarding the choice of an optimal chelating regimen.
Ahmed Salem, Payal Desai, Ahmed Elgebaly
semanticscholar +1 more source
British Journal of Haematology, 2023 Chronic red blood cell transfusion therapy (CRTT) pre-vents strokes and silent cerebral infarcts (SCIs) in children with sickle cell disease (SCD). 1 Deferasirox, a once- daily oral iron chelator, is used to manage transfusion- related iron overload ...
Alison S. Towerman +6 more
semanticscholar +1 more source
Evaluation of Hepatic Enzymes in major β-thalassemic Patients using Deferasirox
Iraqi Journal of Pharmaceutical Sciences, 2022 β-thalassemia major is a genetic disease that causes sever defect in normal hemoglobin synthesis. The patients with β-thalassemia major need periodic blood transfusions that can result in accumulation of body iron, so treatment with iron chelating agent ...
Ahmed Yahya Dallal Bashi +1 more
doaj +1 more source
Deferasirox Derivatives: Ligands for the Lanthanide Series.
Journal of the American Chemical Society, 2023 Deferasirox is an FDA-approved iron chelator used in the treatment of iron toxicity. In this work, we report the use of several deferasirox derivatives as lanthanide chelators.
Daniel N Mangel +8 more
semanticscholar +1 more source
Nickel hydroxide films in contact with an electroactive solution. A study employing electrochemical impedance measurements [PDF]
, 2016 The deactivation of nickel hydroxide films after prolonged storage times without use was studied. This study was carried out in the context of the Rotating Disc Electrode Voltammetry (RDEV) andElectrochemical Impedance Spectroscopy (EIS) when the nickel ...
Tucceri, Ismael Ricardo
core +2 more sources
Efficacy and safety of deferasirox at low and high iron burdens: results from the EPIC magnetic resonance imaging substudy [PDF]
, 2012 The effect of deferasirox dosing tailored for iron burden and iron loading based on liver iron concentration (LIC) was assessed over 1 year in less versus more heavily iron-overloaded patients in a substudy of the Evaluation of Patients' Iron Chelation ...
A. El-Beshlawy +9 more
core +1 more source
Complex interaction of deferasirox and Pythium insidiosum: iron-dependent attenuation of growth in vitro and immunotherapy-like enhancement of immune responses in vivo. [PDF]
PLoS ONE, 2015 Pythium insidiosum iron acquisition mechanisms are unknown. We previously showed that the iron chelator deferasirox had weak activity in vitro and in rabbits with experimental pythiosis. Here we show that deferasirox causes damage to P. insidiosum hyphae
Régis A Zanette +10 more
doaj +1 more source
F1000Research, 2023 Background Excess iron deriving from a chronic transfusion and dietary intake increases the risk for cardiac complications in β-thalassemia major patients.
Khairunnisa Khairunnisa +3 more
doaj +1 more source
Deferasirox Derivatives as Inhibitors of Kallikrein-Related Peptidases Associated to Neurodegenerative Diseases. [PDF]
ChemMedChemBoumali R +11 more
europepmc +3 more sources