Sari Pediatri, 2018 Latar belakang. Talasemia β Mayor merupakan kelainan herediter yang disebabkan gangguan produksi rantai globin. Transfusi rutin menyebabkan kelebihan besi yang tertimbun dalam jaringan sehingga menyebabkan kardiomiopati, gangguan liver, dan komplikasi ...
Aries - Krisbiyantoro +2 more
doaj +1 more source
World Journal of Clinical Cases, 2022 BACKGROUND A perforated gastroduodenal ulcer is rarely observed in children. Certain medications have been reported to cause ulcerations. Deferasirox, an iron chelating agent, has been previously reported to be associated with the development of ...
Abdullah J. AlShehri, Tuqa AlSinan
semanticscholar +1 more source
Iron overload across the spectrum of non-transfusion-dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions [PDF]
, 2017 Non-transfusion-dependent thalassaemias (NTDT) encompass a spectrum of anaemias rarely requiring blood transfusions. Increased iron absorption, driven by hepcidin suppression secondary to erythron expansion, initially causes intrahepatic iron overload ...
Bansal +42 more
core +1 more source
RSC AdvancesHigh concentrations of deferasirox (DFX) in living organisms cause hepatic, gastric and renal malfunctions. Therefore, it is significant to establish an accurate and efficient approach for the detection of deferasirox (DFX) to protect public health ...
Kainat Khurshid +5 more
semanticscholar +1 more source
Residual erythropoiesis protects against myocardial hemosiderosis in transfusion-dependent thalassemia by lowering labile plasma iron via transient generation of apotransferrin [PDF]
, 2017 Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis.
Evans, P +4 more
core +1 more source
Protective Effects of Vitamin C Concomitant Treatment on Deferasirox-induced Renal Toxicity in Rats
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2020 Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress is among f the major causes of nephrotoxicity and its progression.
Taha Fereydouni +3 more
doaj
Deferasirox Causes Leukaemia Cell Death through Nrf2-Induced Ferroptosis
AntioxidantsAcute lymphoblastic leukaemia (ALL) is the most prevalent cancer in children, and excessive iron buildup resulting from blood transfusions and chemotherapy potentially has a negative impact on treatment outcomes and prognosis in patients with ALL ...
Wan-Yi Hsu +5 more
semanticscholar +1 more source
Efektivitas Deferasirox pada Pasien Thalasemia Mayor: Artikel Review
Jurnal Sains dan Kesehatan, 2022 Thalassemia is a heterogeneous grouping of genetic disorders resulting from decreased synthesis of the alpha or beta chains of hemoglobin. Anemia and iron overload are the main causes of morbidity and mortality due to thalassemia disease.
Naksa Garnida Arfie +2 more
semanticscholar +1 more source
Deletion of chromosome 20 in bone marrow of patients with Shwachman-Diamond syndrome, loss of the EIF6 gene and benign prognosis [PDF]
, 2012 Shwachman-Diamond Syndrome (SDS; On-line Mendelian Inheritance in Man database number 260400) is an autosomal recessive disorder caused by mutations in the SBDS gene in at least 90% of cases (Boocock et al, 2003).
Lo Curto F +7 more
core +1 more source
4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid dimethylformamide monosolvate
Acta Crystallographica Section E, 2012 In the molecule of deferasirox dimethylformamide solvate, C21H15N3O4·C3H7NO, the central 1,2,4-triazole ring is tilted with respect to the benzoic acid and one of the 2-hydroxyphenyl units but coplanar with the other 2-hydroxyphenyl group, as ...
H. S. Yathirajan +4 more
doaj +1 more source