Results 61 to 70 of about 13,011 (272)

Efficacy and safety of deferoxamine, deferasirox and deferiprone triple iron chelator combination therapy for transfusion-dependent β-thalassaemia with very high iron overload: a protocol for randomised controlled clinical trial

BMJ Open
Introduction Despite the improvement in medical management, many patients with transfusion-dependent β-thalassaemia die prematurely due to transfusion-related iron overload.
A. Premawardhena, Chamodi Perera, Muditha Nayana Wijethilaka, S. Wanasinghe, R. Rajakaruna, R. Samarasinghe, Senani Williams, S. Mettananda   +7 more
semanticscholar   +1 more source

Development and evaluation of Deferasirox loaded nanoparticles for the treatment of Breast cancer: evaluation in-vitro and cell line study

Ars Pharmaceutica, 2022
Introduction: The aim of the present study was to study the potential efficacy of antitumor activity of nanoparticles loaded with Deferasirox In the current research work, nanoparticle loaded with Deferasirox were developed and evaluated to study its ...
Nilima A. Thombre, Payal Jangam, R. Umarani, Neha Kulkarni, S. Kshirsagar   +4 more
semanticscholar   +1 more source

Preparation of pH-Responsive Vesicular Deferasirox: Evidence from In Silico, In Vitro, and In Vivo Evaluations

ACS Omega, 2021
pH-sensitive nanocarriers can effectively deliver anticancer drugs to tumors and reduce the adverse effects of conventional chemotherapy. In this light, we prepared a novel pH-responsive deferasirox (DFX)-loaded vesicle and comprehensively performed in ...
Mahmood Barani, Saman Sargazi, M. Hajinezhad, Abbas Rahdar, Fakhara Sabir, A. Pardakhty, Farshid Zargari, M. Anwer, M. A. Aboudzadeh   +8 more
semanticscholar   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Deferasirox is a powerful NF-κB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging

Haematologica, 2010
Background Usefulness of iron chelation therapy in myelodysplastic patients is still under debate but many authors suggest its possible role in improving survival of low-risk myelodysplastic patients.
Emanuela Messa, Sonia Carturan, Chiara Maffè, Marisa Pautasso, Enrico Bracco, Antonella Roetto, Francesca Messa, Francesca Arruga, Ilaria Defilippi, Valentina Rosso, Chiara Zanone, Antonia Rotolo, Elisabetta Greco, Rosa M. Pellegrino, Daniele Alberti, Giuseppe Saglio, Daniela Cilloni   +16 more
doaj   +1 more source

Compare the Efficacy and Safety of Deferoxamine, Deferasirox, and Deferiprone in Patients With Sickle Cell Disease or Transfusion-Dependent Anemia: A Network Meta-Analysis of Randomized Control Trials

Cureus
This network meta-analysis was conducted with the aim of comparing the efficacy and safety of deferiprone (DFP), deferasirox (DFX), and deferoxamine (DFO) in individuals with sickle cell disease (SCD) or transfusion-dependent anemia.
D. B. Arrey Agbor, Abhimanyu Karumanchi, Santoshini Adivi, Mohammed A Mohammed, Wajeeh Ur Rehman, Sandipkumar S Chaudhari, Thin M Soe, Neelum Ali   +7 more
semanticscholar   +1 more source

Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells [PDF]

, 2016
Background Overcoming resistance to treatment is an essential issue in many cancers including glioblastoma (GBM), the deadliest primary tumor of the central nervous system.
C. Guillet, C. Legendre, E. Garcion, S. Avril   +3 more
core   +5 more sources

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Comparison of deferasirox and deferoxamine effects on iron overload and immunological changes in patients with blood transfusion-dependent β-thalassemia

Asian Journal of Transfusion Science, 2017
Introduction: Beta-thalassemias are a cluster of inherited (autosomal recessive) hematological disorders prevalent in the Mediterranean area due to defects in synthesis of β chains of hemoglobin.
Hayder M Al-Kuraishy, Ali I Al-Gareeb
doaj   +1 more source

Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss [PDF]

, 2017
L
Jeney, Viktória
core   +1 more source