Results 71 to 80 of about 9,786 (244)
A novel mutation in NDUFB11 unveils a new clinical phenotype associated with lactic acidosis and sideroblastic anemia [PDF]
, 2017 NDUFB11, a component of mitochondrial complex I, is a relatively small integral membrane protein, belonging to the 'supernumerary' group of subunits, but proved to be absolutely essential for the assembly of an active complex I.
Bertini, Enrico +21 more
core +2 more sources
Lavandula angustifolia and Cyperus rotundus Extract Treatments Ameliorate Copper Toxicity in Rats
Brain and Behavior, Volume 15, Issue 7, July 2025.High levels of copper can lead to spatial learning and memory disorders. Extracts from L. angustifolia and C. rotundus have the potential to remove copper from the body and reduce its harmful effects. They achieve this by increasing the expression of the BDNF gene while decreasing the expression of IL‐6, IL1‐B, Caspase‐3, and TNF‐α genes in the ...
Mandana Salari +3 more
wiley +1 more source
Pharmacogenetic Study of Deferasirox, an Iron Chelating Agent [PDF]
PLoS ONE, 2010 Abstract Abstract 2060 Transfusion associated iron overload induce systemic toxicity. Deferoxamine had been used to reduce iron induced toxicities by chelating iron but it is a short acting drug and needs parenteral administration.
Ji Yeob Choi +12 more
openaire +7 more sources
F1000Research, 2023 Background Excess iron deriving from a chronic transfusion and dietary intake increases the risk for cardiac complications in β-thalassemia major patients.
Khairunnisa Khairunnisa +3 more
doaj
Chelator-facilitated removal of iron from transferrin: Relevance to combined chelation therapy [PDF]
, 2007 Current iron chelation therapy consists primarily of DFO (desferrioxamine), which has to be administered via intravenous infusion, together with deferiprone and deferasirox, which are orally-active chelators.
Devanur, LD +3 more
core +3 more sources
Non-Transfusion-Dependent Thalassemia: An Update on Complications and Management [PDF]
, 2018 Patients with non-transfusion-dependent thalassemia (NTDT) experience many clinical complications despite their independence from frequent transfusions.
Bou-Fakhredin, Rayan +5 more
core +3 more sources
M1 Macrophage‐Derived Extracellular Particles Induce Cell Death in MDA‐MB‐231 Cells
Cancer Reports, Volume 8, Issue 7, July 2025.ABSTRACT Background Triple‐negative breast cancer (TNBC), a leading cause of female mortality worldwide, presents a treatment challenge due to the lack of targeted receptors. Macrophages, recognized for their role in the immune response, provide a promising avenue for cancer research.
Parth Desai +5 more
wiley +1 more source
Analytical Sciences, 2016 We describe the effect of different sized gold and silver nanoparticles on the terbium sensitized fluorescence of deferasirox. It is indicated that silver nanostructures, especially 18 nm Ag nanoparticles (AgNPs), have a remarkable amplifying effect compared to Au nanoparticles.
Roza Naderali +2 more
openaire +4 more sources
The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential [PDF]
Cancer MedIron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Vidanapathirana G +4 more
europepmc +2 more sources
Scientific Reports, 2022 Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%.
Mojgan Nazari +10 more
doaj +1 more source