Results 91 to 100 of about 10,843 (242)

Differential effects of Fe2+ and Fe3+ on osteoblasts and the effects of 1,25(OH)2D3, deferiprone and extracellular calcium on osteoblast viability under iron-overloaded conditions

PLoS ONE, 2020
One of the potential contributing factors for iron overload-induced osteoporosis is the iron toxicity on bone forming cells, osteoblasts. In this study, the comparative effects of Fe3+ and Fe2+ on osteoblast differentiation and mineralization were ...
Kornkamon Lertsuwan, K. Nammultriputtar, Supanan Nanthawuttiphan, Natnicha Tannop, Jarinthorn Teerapornpuntakit, Jirawan Thongbunchoo, N. Charoenphandhu   +6 more
semanticscholar   +1 more source

Dynamic dyssynchrony and impaired contractile reserve of the left ventricle in beta-thalassaemia major: an exercise echocardiographic study [PDF]

, 2012
BACKGROUND: Performance of the left ventricle during exercise stress in thalassaemia patients is uncertain. We aimed to explore the phenomenon of dynamic dyssynchrony and assess contractile reserve in patients with beta-thalassaemia major and determine ...
Chan, GCF, Cheung, YF, Ha, SY, Ho, YC, Lam, WWM, Li, SN, Wong, SJ, Yu, W   +7 more
core   +1 more source

Two hydroxy pyridinecarboxylic acid derivatives as a possible chelating agents in neurodegenerative disease; equilibrium complexation studies with Cu(II), Zn(II). [PDF]

, 2014
The metal ion chelators 4-hydroxy-5-methyl-3-pyridinecarboxylic acid (DQ5) and 1,5-dimethyl-4-hydroxy-3-pyridinecarboxylic acid (DQ715) and Cu(II) and Zn(II) were investigated with the aim to restore the homeostasis of the brain Cu(II) and Zn(II) in ...
Dean, Annalisa, Di Marco, Valerio B., Gandin, Valentina, Jakusch, Tamás, Kiss, Tamás, Marzano, Christine, Nagy, Nóra Veronika, Sija, Éva   +7 more
core  

Effects of combined deferiprone with deferoxamine on right ventricular function in thalassaemia major [PDF]

, 2012
BACKGROUND: Combination therapy with deferoxamine and oral deferiprone is superior to deferoxamine alone in removing cardiac iron and improving left ventricular ejection fraction (LVEF).
Carlo Dessi, Dudley J Pennell, Francisco Alpendurada, Gill C Smith, John Walker, John-Paul Carpenter, Mark A Tanner, Renzo Galanello, Sunil V Nair, Winston Banya   +9 more
core   +2 more sources

T1 at 1.5T and 3T compared with conventional T2* at 1.5T for cardiac siderosis [PDF]

, 2015
Background: Myocardial black blood (BB) T2* relaxometry at 1.5T provides robust, reproducible and calibrated non-invasive assessment of cardiac iron burden.
A Meloni, A Meloni, A Pepe, A. John Baksi, AJ Baksi, AJ Fleming, B Modell, D Dabir, David N. Firmin, DJ Pennell, DJ Pennell, DJ Pennell, DM Sado, DM Sado, Dominique Auger, DR Messroghli, DR Messroghli, Dudley J. Pennell, G Abbruzzese, Gillian C. Smith, H Guo, JB Porter, JC Moon, JC Wood, JM Bland, JP Carpenter, JP Carpenter, JP Carpenter, JW Eaton, LJ Anderson, M Fontana, MA Tanner, MA Tanner, MA Westwood, Mohammed H. Alam, P Kellman, P Kellman, P Kirk, P Kirk, P Kirk, P Kirk, P Storey, Peter Drivas, Rick Wage, S Bull, S Roujol, SK Piechnik, T He, T He, Taigang He, TC Wong, TC Wong, TD Karamitsos, Vassilis Vassiliou, W Collins, X Gao, Y Feng, Yanqiu Feng   +57 more
core   +3 more sources

Evaluation of the protective activity of deferiprone, an aluminum chelator, on aluminum-induced developmental toxicity in mice [PDF]

, 2000
M. Luisa Albina, Montserrat Bell�s, Domènec J. Sánchez, José L. Domingo   +3 more
openalex   +1 more source

Lenalidomide for the Treatment of Low- or Intermediate-1-Risk Myelodysplastic Syndromes Associated with Deletion 5q Cytogenetic Abnormality: An Evidence Review of the NICE Submission from Celgene [PDF]

, 2015
The National Institute for Health and Care Excellence (NICE) invited the manufacturer of lenalidomide (Celgene) to submit evidence of the clinical and cost effectiveness of the drug for treating adults with myelodysplastic syndromes (MDS) associated with
Al, M.J. (Maiwenn), Armstrong, N. (Nigel), Blommestein, H.M. (Hedwig), Deshpande, S. (Sohan), Kleijnen, J.M.P. (Jos), Noake, C. (Caro), Riemsma, R. (Rob), Ryder, S. (Steve), Severens, J.L. (Hans), Worthy, G. (Gill)   +9 more
core   +4 more sources

Estimates of the effect on hepatic iron of oral deferiprone compared with subcutaneous desferrioxamine for treatment of iron overload in thalassemia major: a systematic review [PDF]

, 2002
J. Jaime, Krista F. Huybrechts, Traci C. Green   +2 more
openalex   +1 more source

28-jähriger Patient mit erfolgreich behandelter dilatativer Kardiomyopathie [PDF]

, 2018
Zusammenfassung: Ein 28-jähriger Patient wurde mit dekompensierter Herzinsuffizienz notfallmäßig zugewiesen. In der Vorgeschichte bestand ein hypogonadotroper Hypogonadismus. Echokardiographisch fand sich eine dilatative Kardiomyopathie.
Burri, E., Buser, P., Decker, M., Eriksson, U., Hunziker, L.   +4 more
core  

Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone [PDF]

, 2003
Alan R. Cohen, Renzo Galanello, Antonio Piga, Vincenzo De Sanctis, Fernando Tricta   +4 more
openalex   +1 more source