Results 1 to 10 of about 894,956 (297)

Contrastive Learning for Representation Degeneration Problem in Sequential Recommendation [PDF]

Web Search and Data Mining, 2021
Recent advancements of sequential deep learning models such as Transformer and BERT have significantly facilitated the sequential recommendation. However, according to our study, the distribution of item embeddings generated by these models tends to ...
Ruihong Qiu, Zi Huang, Hongzhi Yin, Zijian Wang   +3 more
semanticscholar   +1 more source

RealToxicityPrompts: Evaluating Neural Toxic Degeneration in Language Models [PDF]

Findings, 2020
Pretrained neural language models (LMs) are prone to generating racist, sexist, or otherwise toxic language which hinders their safe deployment. We investigate the extent to which pretrained LMs can be prompted to generate toxic language, and the ...
Samuel Gehman, Suchin Gururangan, Maarten Sap, Yejin Choi, Noah A. Smith   +4 more
semanticscholar   +1 more source

Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2022
Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back pain (LBP), causing a significant global disability. The IVD consists of an inner core proteoglycan-rich nucleus pulposus (NP) and outer lamellae collagen-rich ...
I. L. Mohd Isa, S. Teoh, N. H. Mohd Nor, S. Mokhtar   +3 more
semanticscholar   +1 more source

Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions

Bone Research, 2021
Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research has identified inflammation and related signaling pathways as important factors in the onset ...
Feng-Juan Lyu, Haowen Cui, H. Pan, Kenneth Mc Cheung, Xu Cao, J. Iatridis, Zhaomin Zheng   +6 more
semanticscholar   +1 more source

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

Nature Communications, 2021
Intervertebral disc degeneration is highly prevalent within the elderly population and is a leading cause of chronic back pain and disability. Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and ...
E. J. Novais, V. Tran, Shira N. Johnston, K. Darris, Alex J Roupas, G. Sessions, I. Shapiro, B. Diekman, M. Risbud   +8 more
semanticscholar   +1 more source

Treatment of Intervertebral Disc Degeneration

Orthopaedic Surgery, 2022
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs.
Jingguo Xin, Yongjie Wang, Zhiying Zheng, Shuo Wang, Shibo Na, Shaokun Zhang   +5 more
semanticscholar   +1 more source

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

Nature Network Boston, 2020
With the potential development of new disease-modifying Alzheimer’s disease (AD) therapies, simple, widely available screening tests are needed to identify which individuals, who are experiencing symptoms of cognitive or behavioral decline, should be ...
Elisabeth H Thijssen, R. La Joie, Amy Wolf, Amelia Strom, Ping Wang, Leonardo Iaccarino, Viktoriya Bourakova, Y. Cobigo, H. Heuer, S. Spina, L. Vandevrede, Xiyun Chai, Nicholas K. Proctor, D. Airey, S. Shcherbinin, C. Duggan Evans, J. Sims, H. Zetterberg, K. Blennow, A. Karydas, C. Teunissen, J. Kramer, L. Grinberg, W. Seeley, H. Rosen, B. Boeve, B. Miller, G. Rabinovici, J. Dage, J. Rojas, A. Boxer, Leah David S. Neill Murray Edward H. Chiadi Daniel Erik Forsberg Knopman Graff-Radford Grossman Huey Onyik, L. Forsberg, D. Knopman, N. Graff-Radford, M. Grossman, Edward Huey, C. Onyike, D. Kaufer, E. Roberson, N. Ghoshal, S. Weintraub, B. Appleby, I. Litvan, D. Kerwin, M. Mendez, Y. Bordelon, G. Coppola, E. Ramos, M. Tartaglia, G. Hsiung, I. Mackenzie, K. Domoto-Reilly, T. Foroud, B. Dickerson   +54 more
semanticscholar   +1 more source

Novel tau filament fold in corticobasal degeneration

Nature, 2020
Corticobasal degeneration (CBD) is a neurodegenerative tauopathy—a class of disorders in which the tau protein forms insoluble inclusions in the brain—that is characterized by motor and cognitive disturbances 1 – 3 .
Wenjuan Zhang, A. Tarutani, K. Newell, A. Murzin, T. Matsubara, B. Falcon, R. Vidal, H. Garringer, Yang Shi, T. Ikeuchi, S. Murayama, B. Ghetti, M. Hasegawa, M. Goedert, S. Scheres   +14 more
semanticscholar   +1 more source

Ranibizumab in neovascular age-related macular degeneration

Clinical Interventions in Aging, 2006
Neovascular age-related macular degeneration (AMD) is a visually devastating condition resulting from choroidal neovascularization and secondary photoreceptor loss.
K. Eng, P. Kertes
semanticscholar   +1 more source

Risk factors for progression of age‐related macular degeneration

Ophthalmic & physiological optics, 2020
Age‐related macular degeneration (AMD) is a degenerative disease of the macula, often leading to progressive vision loss. The rate of disease progression can vary among individuals and has been associated with multiple risk factors.
Thomas J. Heesterbeek, L. Lorés-Motta, C. Hoyng, Y. Lechanteur, A. D. den Hollander   +4 more
semanticscholar   +1 more source