Results 21 to 30 of about 894,956 (297)

Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria

Cells, 2022
Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly, two of the major risk factors for these diseases, aging and obesity, are also global problems.
Fiona Frederike Cox, Angelina Misiou, Annika Vierkant, Niloofar Ale-Agha, Maria Grandoch, Judith Haendeler, Joachim Altschmied   +6 more
doaj   +1 more source

NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion

Cells, 2020
Osteoclasts are the sole bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathogenic bone destruction such as inflammatory arthritis.
Peter Sang Uk Park, Se Hwan Mun, Steven L. Zeng, Haemin Kim, Seyeon Bae, Kyung-Hyun Park-Min   +5 more
doaj   +1 more source

Comparisons of the Efficacy and Safety of Total Knee Arthroplasty by Different Surgical Approaches: A Systematic Review and Network Meta‐analysis

Orthopaedic Surgery, 2022
The purpose of this network meta‐analysis was to investigate the efficacy and safety of total knee arthroplasty (TKA) considering seven different surgical approaches.
Jin‐long Zhao, Ling‐feng Zeng, Jian‐ke Pan, Gui‐hong Liang, He‐tao Huang, Wei‐yi Yang, Ming‐hui Luo, Jun Liu   +7 more
doaj   +1 more source

Dual stimulus responsive borosilicate glass (BSG) scaffolds promote diabetic alveolar bone defectsrepair by modulating macrophage phenotype

Bioactive Materials, 2023
The regeneration of alveolar bone is still clinical challenge, particularly accompanied with diabetes, causing metabolic disorder with a protracted low-grade inflammatory phenotype.
Pengfei Tian, Limin Zhao, Jua Kim, Xian Li, Chunyu Liu, Xu Cui, Tao Liang, Yunbo Du, Xiehui Chen, Haobo Pan   +9 more
doaj   +1 more source

AMPK Signaling in Energy Control, Cartilage Biology, and Osteoarthritis

Frontiers in Cell and Developmental Biology, 2021
The adenosine monophosphate (AMP)–activated protein kinase (AMPK) was initially identified as an enzyme acting as an “energy sensor” in maintaining energy homeostasis via serine/threonine phosphorylation when low cellular adenosine triphosphate (ATP ...
Dan Yi, Dan Yi, Huan Yu, Huan Yu, Ke Lu, Ke Lu, Changshun Ruan, Changhai Ding, Changhai Ding, Liping Tong, Xiaoli Zhao, Di Chen, Di Chen   +12 more
doaj   +1 more source

The M-CSF receptor in osteoclasts and beyond

Experimental and Molecular Medicine, 2020
Bone disease: Signaling pathway offers promising drug target Drugs directed at a key signaling receptor involved in breaking down bone tissue could help treat diseases marked by pathological bone loss and destruction. In a review article, Kyung-Hyun Park-
Se Hwan Mun, Peter Sang Uk Park, Kyung-Hyun Park-Min   +2 more
doaj   +1 more source

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

Nature Communications, 2018
The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of ...
Upneet K. Sokhi, Mark P. Liber, Laura Frye, Sungho Park, Kyuho Kang, Tania Pannellini, Baohong Zhao, Rada Norinsky, Lionel B. Ivashkiv, Shiaoching Gong   +9 more
doaj   +1 more source

Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell‐derived retinal organoids

Cell Death Discovery, 2022
Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial and temporal differentiation of retinal cell types.
Si Hyung Lee, Jung Woo Han, Jin Young Yang, Hyoung Oh Jun, Ji Hong Bang, Heejeong Shin, Ji Hye Choi, Jongwoo Lee, Sanjar Batirovich Madrakhimov, Kyung Hwun Chung, Hun Soo Chang, Jungmook Lyu, Tae Kwann Park   +12 more
doaj   +1 more source

Simultaneous application of diamond-like carbon coating and surface amination on polyether ether ketone: Towards superior mechanical performance and osseointegration

Smart Materials in Medicine, 2021
Poor osseointegration ability and the release of worn debris after implantation are the main issues impeding the clinic application of polyether ether ketone (PEEK) as orthopedics.
Shi Mo, Feilong Zhao, Ang Gao, Yuzheng Wu, Qing Liao, Lingxia Xie, Haobo Pan, Liping Tong, Paul K. Chu, Huaiyu Wang   +9 more
doaj   +1 more source

The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

Scientific Reports, 2021
Bacopa monnieri (Linn.) Wettst. has been used in traditional medicine as a drug to enhance and improve memory. In this regard, this study aims to provide B.
James M. Brimson, Sirikalaya Brimson, Mani Iyer Prasanth, Premrutai Thitilertdecha, Dicson Sheeja Malar, Tewin Tencomnao   +5 more
doaj   +1 more source