Results 31 to 40 of about 1,030,335 (270)

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss [PDF]

open access: yes, 2005
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration.
Petzold, A
core   +1 more source

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration-Correlation with histological grading in a rabbit disc degeneration model. [PDF]

open access: yes, 2019
Introduction:Estimation of intervertebral disc degeneration on magnetic resonance imaging (MRI) is challenging. Qualitative schemes used in clinical practice correlate poorly with pain and quantitative techniques have not entered widespread clinical use.
Chamoli, Uphar   +5 more
core   +1 more source

Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell‐derived retinal organoids

open access: yesCell Death Discovery, 2022
Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial and temporal differentiation of retinal cell types.
Si Hyung Lee   +12 more
doaj   +1 more source

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

open access: yesNature Communications, 2019
Macrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3 ...
Kyuho Kang   +6 more
doaj   +1 more source

Degenerations of K3 Surfaces of Degree Two [PDF]

open access: yes, 2010
We consider a semistable degeneration of K3 surfaces, equipped with an effective divisor that defines a polarisation of degree two on a general fibre. We show that the map to the relative log canonical model of the degeneration maps every fibre to either
Thompson, Alan
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Limitations and modifications in the clinical application of calcium sulfate

open access: yesFrontiers in Surgery
Calcium sulfate and calcium sulfate-based biomaterials have been widely used in non-load-bearing bone defects for hundreds of years due to their superior biocompatibility, biodegradability, and non-toxicity.
Deng-xing Lun   +7 more
doaj   +1 more source

Glucocorticoid‐induced osteonecrosis in systemic lupus erythematosus patients

open access: yesClinical and Translational Medicine, 2021
Osteonecrosis (ON) is a complex and multifactorial complication of systemic lupus erythematosus (SLE). ON is a devastating condition that causes severe pain and compromises the quality of life.
Kaichi Kaneko   +5 more
doaj   +1 more source

Selenoprotein T Protects Endothelial Cells against Lipopolysaccharide-Induced Activation and Apoptosis

open access: yesAntioxidants, 2021
Sepsis is an exaggerated immune response upon infection with lipopolysaccharide (LPS) as the main causative agent. LPS-induced activation and apoptosis of endothelial cells (EC) can lead to organ dysfunction and finally organ failure.
Dennis Merk   +11 more
doaj   +1 more source

Toric Representation and Positive Cone of Picard Group and Deformation Space in Mirror Symmetry of Calabi-Yau Hypersurfaces in Toric Varieties [PDF]

open access: yes, 2011
We derive the combinatorial representations of Picard group and deformation space of anti-canonical hypersurfaces of a toric variety using techniques in toric geometry. The mirror cohomology correspondence in the context of mirror symmetry is established
Roan, Shi-shyr
core  

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