Results 31 to 40 of about 625,920 (299)

Chitosan modified with PAP as a promising delivery system for melatonin in the treatment of osteoporosis: targeting the divalent metal transporter 1

Journal of Biological Engineering
The demands for novel and efficient therapies have gradually increased with the rising concerns of osteoporosis (OP). The most popular method in promoting bone regeneration during osteoporotic conditions consists of loading bioactive materials with ...
Weilin Zhang, Hongrui Rong, Jinguo Liang, Chao Mao, Zhencong Li, Zhiwen Dai, Dingbin Li, Weixiong Guo, Siyuan Chen, Zhongwei Wang, Jinsong Wei   +10 more
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Polyethylene microplastics trigger osteosarcoma progression via ITGA5/FAPα/LGMN cancer promoting complex: A novel environmental cancer promoting mechanism

Ecotoxicology and Environmental Safety
This study seeks to elucidate the molecular mechanisms by which polyethylene microplastics (PE-MPs) facilitate the progression of osteosarcoma through the modulation of the ITGA5/FAPα/LGMN protein complex.
Weilin Zhang, Shengbang Huang, Kuize Liu, Dao Feng, Jinguo Liang, Zhencong Li, Boyuan Zhou, Zhiwen Dai, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effect of daphnetin combined with tobramycin on Pseudomonas aeruginosa biofilm infection in vitro and in vivo

Frontiers in Immunology
ObjectiveThe aim of this study was to investigate the effectiveness of daphnetin in combination with tobramycin on Pseudomonas aeruginosa biofilm infection in vitro and in vivo.MethodThe study was divided into four groups: control, tobramycin, daphnetin,
Dingbin Li, Chao Mao, Siyuan Chen, Zhongwei Wang, Weilin Zhang, Zhencong Li, Liangsheng Li, Chaoqin He, Weixiong Guo, Jinsong Wei, Qingjun Wei   +10 more
doaj   +1 more source

Degenerate dynamical systems [PDF]

Journal of Mathematical Physics, 2001
Dynamical systems, whose symplectic structure degenerates, becoming noninvertible at some points along the orbits, are analyzed. It is shown that for systems with a finite number of degrees of freedom, like in classical mechanics, the degeneracy occurs on domain walls that divide phase space into nonoverlapping regions, each one describing a ...
Saavedra, J, Troncoso, R, Zanelli, J
openaire   +9 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Journal of Biological Engineering
Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the ...
Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source

IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages

Cell Reports, 2016
The mechanisms by which IFN-γ activates expression of interferon-stimulated genes that have inflammatory and host defense functions are well understood. In contrast, little is known about how IFN-γ represses gene expression.
Yu Qiao, Kyuho Kang, Eugenia Giannopoulou, Celeste Fang, Lionel B. Ivashkiv   +4 more
doaj   +1 more source

More Than Words: Extra-Sylvian Neuroanatomic Networks Support Indirect Speech Act Comprehension and Discourse in Behavioral Variant Frontotemporal Dementia

Frontiers in Human Neuroscience, 2021
Indirect speech acts—responding “I forgot to wear my watch today” to someone who asked for the time—are ubiquitous in daily conversation, but are understudied in current neurobiological models of language.
Meghan Healey, Meghan Healey, Erica Howard, Molly Ungrady, Christopher A. Olm, Christopher A. Olm, Naomi Nevler, David J. Irwin, David J. Irwin, Murray Grossman, Murray Grossman   +10 more
doaj   +1 more source