Results 51 to 60 of about 1,030,335 (270)
Degenerate dynamical systems [PDF]
Journal of Mathematical Physics, 2001 Dynamical systems, whose symplectic structure degenerates, becoming noninvertible at some points along the orbits, are analyzed. It is shown that for systems with a finite number of degrees of freedom, like in classical mechanics, the degeneracy occurs on domain walls that divide phase space into nonoverlapping regions, each one describing a ...
Saavedra, J, Troncoso, R, Zanelli, J
openaire +9 more sources
Excluded homeomorphism types for dual complexes of surfaces
, 2015 We study an obstruction to prescribing the dual complex of a strict semistable degeneration of an algebraic surface. In particular, we show that if $\Delta$ is a complex homeomorphic to a 2-dimensional manifold with negative Euler characteristic, then ...
Cartwright, Dustin
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Journal of Biological EngineeringDisc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the ...
Zhencong Li +9 more
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Cell Reports, 2016 The mechanisms by which IFN-γ activates expression of interferon-stimulated genes that have inflammatory and host defense functions are well understood. In contrast, little is known about how IFN-γ represses gene expression.
Yu Qiao +4 more
doaj +1 more source
Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism
Cells, 2021 Bone is a dynamic tissue and is constantly being remodeled by bone cells. Metabolic reprogramming plays a critical role in the activation of these bone cells and skeletal metabolism, which fulfills the energy demand for bone remodeling.
Haemin Kim +2 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Frontiers in Human Neuroscience, 2021 Indirect speech acts—responding “I forgot to wear my watch today” to someone who asked for the time—are ubiquitous in daily conversation, but are understudied in current neurobiological models of language.
Meghan Healey +10 more
doaj +1 more source