Results 101 to 110 of about 2,128,954 (339)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

MOV10 Is a 5′ to 3′ RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation along 3′ UTRs [PDF]

, 2014
Lea H. Gregersen, Markus Schueler, Mathias Munschauer, Guido Mastrobuoni, Wei Chen, Stefan Kempa, Christoph Dieterich, Markus Landthaler   +7 more
openalex   +1 more source

The impact of logging on vertical canopy structure across a gradient of tropical forest degradation intensity in Borneo

, 2021
David T. Milodowski, David A. Coomes, Tom Swinfield, Tommaso Jucker, Terhi Riutta, Yadvinder Malhi, Martin Svátek, Jakub Kvasnica, David F. R. P. Burslem, Robert M. Ewers, Yit Arn Teh, Mathew Williams   +11 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against Foulants

Advanced Materials Interfaces
Antifouling coatings are vital to enhance the performance of medical devices, aiming to mitigate bodily reactions by shielding their surface. Despite significant advancements in antifouling coatings, like those based on zwitterionic monomers and hydroxyl‐
Jenny Englert, Marc Palà, Jonas Quandt, Hannah Sieben, Oliver Grottke, Bernd Marx, Gerard Lligadas, Cesar Rodriguez‐Emmenegger   +7 more
doaj   +1 more source

Composição química e degradabilidade in situ da ração em ovinos em área de caatinga no sertão de Pernambuco Chemical composition and in situ digestibility of diets for sheep in the caatinga region

Revista Brasileira de Zootecnia, 2009
Objetivou-se avaliar o efeito do tipo de fístula e da hora de coleta sobre a composição química e a degradabilidade in situ da ração em ovinos criados na caatinga.
Gladston Rafael de Arruda Santos, Ângela Maria Vieira Batista, Adriana Guim, Mércia Virginia Ferreira dos Santos, Daniele Silva de Matos, Kleber Régis Santoro   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Estudo das propriedades mecânicas e elétricas de fibras de curauá modificada com polianilina Study on mechanical and electrical properties of curaua fibers modified with polianiline

Polímeros, 2010
Fibras naturais têm sido empregadas em diversos compósitos, principalmente na indústria automobilística. Dentre as diversas fibras naturais, a fibra de curauá é atraente por apresentar elevada propriedade mecânica associada a baixos valores de densidade.
Fernando G. de S. Junior, Paulo H. S. Picciani, Eli V. da Rocha, Geiza E. de Oliveira   +3 more
doaj  

Qualitative and anatomical characteristics of tree-shrub legumes in the Forest Zone in Pernambuco state, Brazil

Revista Brasileira de Zootecnia, 2012
The objective of this study was to characterize the nutritional value of forage legumes Mimosa caesalpiniifolia (Benth.), Bauhinia cheilantha (Bong.) and Leucaena leucocephala (Lan.) and evaluate the anatomy of plants incubated and not incubated in the ...
Mônica Alixandrina da Silva, Mércia Virginia Ferreira dos Santos, Mario de Andrade Lira, José Carlos Batista Dubeux Júnior, Dulciene Karla de Andrade Silva, Kleber Régis Santoro, Paulo Marcio Barbosa de Arruda Leite, Erinaldo Viana de Freitas   +7 more
doaj   +1 more source

Cytoplasmic degradation of ssrA‐tagged proteins [PDF]

, 2005
Christopher M. Farrell, Alan D. Grossman, Robert T. Sauer   +2 more
openalex   +1 more source